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Casirivimab Imdevimab (Regn-Cov2) Injection
Prescription Required
Salt Composition : Casirivimab,imdevimab
Manufacturer : CIPLA LTD
Origin of Medicine : United States of America, Switzerland
2 Multi Dose Vial(s)
Introduction to Casirivimab Imdevimab (regn-cov2) Injection
Casirivimab Imdevimab (Regn-COV2) injection contains the active constituent Casirivimab + Imdevimab, a type of protein called monoclonal antibodies. It is used to treat patients with confirmed acute COVID-19 infection. It is also indicated to prevent acute COVID-19 infection. Acute covid-19 infection is caused by a virus called coronavirus. People can get COVID-19 through contact with another person who has the virus.
Do not take Casirivimab Imdevimab (Regn-COV2) injection if you are allergic to Casirivimab + Imdevimab or any other ingredients. This medicine can cause allergic reactions following the infusion or injection; notify your physician immediately if you face any of the infusion reactions. Before you take this injection, inform your doctor if you have been vaccinated against COVID infection. Inform your doctor if you are pregnant or breastfeeding before initiating the treatment.
The side effects of this Casirivimab Imdevimab (Regn-COV2) injection monoclonal antibody therapy are injection site reactions, fever, flushing, shortness of breath, chest tightness, nausea, and vomiting. If you experience any of these side effects, immediately inform your doctor. This medicine is recommended to use in individuals aged 12 years and older and weighing at least 35.5kg.
Uses of Casirivimab Imdevimab (regn-cov2) Injection
Uses of Casirivimab Imdevimab (Regn-COV2) injection:
- Treat and prevent acute COVID-19 infection.
Therapeutic Effects of Casirivimab Imdevimab (regn-cov2) Injection
Casirivimab Imdevimab (Regn-COV2) injection are two recombinant human monoclonal antibodies that attach to a protein on the surface of the coronavirus called the ‘spike protein.’ This stops the virus from getting into your cells and causing an infection. They block the receptor binding domain (RBD) to the ACE2 receptor and prevent viral attachment to host cells. This can help your body to overcome the virus infection and may help you get better faster.
Interaction of Casirivimab Imdevimab (regn-cov2) Injection with other drugs
Inform your healthcare provider about all the medicines you take, including prescription medications, over-the-counter medications, nutritional, vitamin supplements, and herbal products. Certain medications interact with Casirivimab Imdevimab (Regn-COV2) injection, reducing their effectiveness by causing undesirable side effects.
More Information about Casirivimab Imdevimab (regn-cov2) Injection
- Store in a refrigerator (2°C to 8°C)
- Do not freeze
- Protect the medicine from light and excessive moisture.
- Keep the medicine out of reach of children and pets
- If you missed the dosing schedule, inform your healthcare professional immediately and reschedule.
How to consume Casirivimab Imdevimab (regn-cov2) Injection
Casirivimab Imdevimab (Regn-COV2) injection is given as an infusion into your vein that lasts for 20 to 30 minutes, or it can be given as a subcutaneous (under the skin) injection. This injection will be given to you by a doctor or nurse who is experienced in the use of this type of treatment. They will monitor you closely while you are being given this medicine. Do not self-administer this medicine.
Safety Advices for Casirivimab Imdevimab (regn-cov2) Injection
Pregnancy
There is limited information on the safety of Casirivimab Imdevimab (Regn-COV2) injection during pregnancy. Inform your physician if you are pregnant, suspecting, or planning for pregnancy
Breast Feeding
There is limited information on the safety of Casirivimab Imdevimab (Regn-COV2) injection during breastfeeding. Inform your physician if you are pregnant, suspecting, or planning for pregnancy.
Lungs
It is unknown whether Casirivimab Imdevimab (Regn-COV2) injection can be used in patients with lung disorders. Consult your doctor if you have any lung diseases before starting the treatment.
Liver
There is limited information available on the use of Casirivimab Imdevimab (Regn-COV2) injection in patients with liver diseases. Inform your physician if you have any liver problems, before initiating the treatment.
Alcohol
It is unknown whether it is safe to consume alcohol with Casirivimab Imdevimab (Regn-COV2) injection. Inform your physician if you are a chronic drinker
Driving
Casirivimab Imdevimab (Regn-COV2) injection does not affect your ability to drive and operate heavy machinery. Inform your physician if you face any symptoms that alter your concentration.
Side Effects of Casirivimab Imdevimab (regn-cov2) Injection
Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them.
Serious
- Hypersensitivity reaction
- Infusion reaction
Word of Advice
Self isolate and use infection control measures (eg, wearing mask, social distancing, avoid sharing personal items, clean and disinfecting “high touch” surfaces, and frequent handwashing). The most common side effects may include infusion-related reactions such as swelling in the hands, face, and feet, skin rash, breathing difficulties, cough, abdominal pain, and chest pain. Injection site reactions like swelling and redness at the injection site can also occur.
FAQs
Q 1. How effective is Casirivimab Imdevimab (Regn-COV2) injection in treating COVID-19?
Clinical studies have shown that Casirivimab Imdevimab (Regn-COV2) injection can significantly reduce the risk of hospitalization or death in high-risk individuals with COVID-19. However, the effectiveness may vary depending on individual factors, including the illness's severity and specific variants of the virus.
Q 2. Can Casirivimab Imdevimab (Regn-COV2) injection be used in combination with other COVID-19 treatments?
Casirivimab Imdevimab (Regn-COV2) injection can be used alone or in combination with other COVID-19 treatments as determined by healthcare professionals. It is important to consult with healthcare providers to ensure proper coordination of treatments and minimize any potential interactions.
Q 3. How soon after testing positive for COVID-19 should Casirivimab Imdevimab (Regn-COV2) injection be administered?
Casirivimab Imdevimab (Regn-COV2) injection is most effective when administered early after testing positive for COVID-19, ideally within 10 days of symptom onset. Early treatment helps reduce the severity of illness and the risk of hospitalization.
Q 4. Can Casirivimab Imdevimab (Regn-COV2) injection be used in pediatric patients?
Yes, Casirivimab Imdevimab (Regn-COV2) injection is authorized for use in pediatric patients aged 12 years and older who weigh at least 35.5kg and are at high risk of developing severe COVID-19.
Q 5. Can Casirivimab Imdevimab (Regn-COV2) injection be used as a substitute for COVID-19 vaccination?
No, Casirivimab Imdevimab (Regn-COV2) injection is not a substitute for COVID-19 vaccination. Vaccination is the most effective way to prevent COVID-19 and its complications. This injection is specifically used to treat individuals who have already tested positive for the virus and are at high risk of developing the infection.
References
- Ronapreve 120 mg/mL solution for injection or infusion - Summary of Product Characteristics (SmPC) - (EMC). www.medicines.org.uk. Published January 2023. Accessed May 22, 2023.
- fact sheet for health care providers emergency use authorization (eua) of regen-cov tm (Casirivimab with Imdevimab); (Revised January 2022.) Accessed May 22, 2023 https://www.fda.gov/media/145611/download
- Paroma Deb et al; An update to the monoclonal antibody as a therapeutic option against COVID-19, [Published on Apr 2021], [Accessed May 22, 2023] https://www.sciencedirect.com/science/article/pii/S2590053621000197
- John P Manis; Overview of therapeutic monoclonal antibodies, [Published on May 2021], [Accessed May 22, 2023], https://www.uptodate.com/contents/overview-of-therapeutic-monoclonal-antibodies#H395449287
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