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Plegridy 125mcg Injection
Prescription Required
Salt Composition : Pegylated Interferon Beta-1a
Manufacturer : EISAI PHARMACEUTICALS INDIA PVT LTD
Origin of Medicine : Japan
1 Prefilled Pen Device(s)
Introduction to Plegridy 125mcg Injection
Plegridy 125mcg injection contains active components as Pegylated Interferon Beta-1A. It is a medication used to treat multiple sclerosis (MS). Multiple sclerosis is a chronic autoimmune disease of the central nervous system characterized by inflammation, demyelination, and a wide range of neurological symptoms. One of the primary benefits of this medication is its ability to reduce the frequency of relapses in individuals with relapsing forms of MS. This can lead to a more stable disease course.: Modulating the immune response and reducing inflammation may slow down the progression of disability in people with MS. This can help individuals maintain a higher level of functioning for a longer period.
Individuals who have a known hypersensitivity or allergy to Plegridy 125mcg injection or any of its components should not use this medication. Suppose a patient has a history of severe depression, significant mood disorders, or suicidal ideation. In that case, the use of this medication should be carefully considered as it can have neuropsychiatric side effects. It can affect liver function, and individuals with severe liver disease or liver dysfunction should not use this medication. Although it primarily undergoes hepatic metabolism (in the liver), it is also partially excreted through the kidneys. Patients with severe renal impairment may require dose adjustments or alternative treatments. The safety and effectiveness of Plegridy 125mcg injection in pediatric patients have not been established, and it is generally not recommended for use in children.
Uses of Plegridy 125mcg Injection
- Multiple sclerosis (MS) treatment
- Relapse rate reduction
- Delaying disability progression
- Inflammation and immune modulation
- MRI lesion reduction
- Alternative disease-modifying therapy (DMT)
Therapeutic Effects of Plegridy 125mcg Injection
Plegridy 125mcg injection works by modulating the immune system's response, reducing inflammation, and shifting it towards an anti-inflammatory state. This mechanism helps decrease immune cell activation, lowers pro-inflammatory molecule production, and inhibits immune cell migration into the central nervous system. As a result, it reduces the frequency of relapses and delays disability progression in individuals with multiple sclerosis (MS).
Interaction of Plegridy 125mcg Injection with other drugs
Inform the doctor about your medicines, including prescription, over-the-counter, nutritional or vitamin supplements, and herbal products. Certain medications may interact with Plegridy 125mcg injection, reducing effectiveness by causing undesirable side effects.Â
More Information about Plegridy 125mcg Injection
- Stored at room temperature from 2°C to 8°C
- Keep away from moisture, heat, and light.
- It should not be frozen.
- Keep away from children and pets.
How to consume Plegridy 125mcg Injection
Plegridy 125mcg injection is typically administered via subcutaneous injection. It is essential to follow your healthcare provider's guidance and any instructions provided with the medication.
Safety Advices for Plegridy 125mcg Injection
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Pregnancy
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There is limited information on the safety of Plegridy 125mcg injection in pregnant women. It is, therefore, important to talk to your doctor before using it if you are pregnant.
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Breast Feeding
 ÂIt is not known whether Plegridy 125mcg injection passes into breast milk. It is, therefore, important to talk to your doctor before using it if you are breastfeeding.
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Lungs
  Plegridy 125mcg injection does not directly affect lung function. However, individuals with lung issues should consult a healthcare provider before using it.
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Liver
  Plegridy 125mcg injection can affect liver function, so it is important to consult a healthcare provider before taking this medication.
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Alcohol
 ÂThe interaction between alcohol and Plegridy 125mcg injection is not well-documented. However, alcohol can have its own effects on the liver and the central nervous system, and it's advisable to consume alcohol in moderation or as your healthcare provider recommends.
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Driving
  Plegridy 125mcg injection does do not cause any side effects that would affect your driving ability. However, if you experience dizziness or other unusual side effects, it's best to consult your healthcare provider.
Side Effects of Plegridy 125mcg Injection
Plegridy 125mcg injection causes some side effects like all medications, although not everyone will experience them.Â
Serious
- Liver problems
- Myelosuppression
- Neuropsychiatric effects
- Allergic reactions
- Anaphylaxis
- Cardiovascular issues
- Seizures
- Autoimmune disorders
Common
- Flu-like symptoms
- Injection site reactions
- Headache
- Nausea
- Fatigue
- Mood changes
Word of Advice
When using plegridy 125mcg injection, it is essential to be cautious if you have known allergies to the medication, monitor for mood changes or depression, and undergo regular liver function tests, especially if you have liver disease. Watch for signs of reduced blood cell counts, report any history of seizures or autoimmune disorders to your healthcare provider, and discuss the medication's safety during pregnancy and breastfeeding. It's generally not recommended for children. Be mindful of your cardiovascular health, consume alcohol in moderation, and be cautious if any side effects affect your driving ability. Always follow your healthcare provider's guidance for safe and effective treatment.
FAQs
Q 1. What should I do if I miss a dose of plegridy 125mcg injection?
If you miss a dose of plegridy 125mcg injection, consult your healthcare provider or the medication's instructions for specific guidance. It's important to maintain the recommended dosing schedule as closely as possible to maximize the medication's effectiveness.
Q 2. Are there any specific dietary restrictions while on plegridy 125mcg injection?
There are no specific dietary restrictions associated with plegridy 125mcg injection . However, maintaining a balanced and healthy diet can contribute to your overall well-being, which is important in managing MS. Always consult your healthcare provider for personalized dietary advice.
Q 3. Is there a risk of developing neutralizing antibodies against plegridy 125mcg injection?
While it's possible to develop neutralizing antibodies over time, it's relatively uncommon with plegridy 125mcg injection compared to some other MS treatments. Your healthcare provider may periodically test for the presence of these antibodies.
Q 4. What steps should I take when traveling with plegridy 125mcg injection?
If you plan to travel, ensure you have a plan in place for storing and transporting plegridy 125mcg injection at the appropriate temperature. Carry necessary supplies, such as syringes and alcohol swabs, and ensure you can access medical care while away from home. Inform your healthcare provider about your travel plans for any additional guidance or precautions.
Q 5. What should I do if I experience an adverse reaction to plegridy 125mcg injection?
Seek immediate medical attention if you encounter a severe or unexpected adverse reaction with plegridy 125mcg injection. For less severe side effects or questions about your treatment, contact your healthcare provider or their office for guidance and support.
Q 6. What should I do if I need surgery or medical procedures while on plegridy 125mcg injection?
Inform your surgeon or healthcare provider about plegridy 125mcg injection before any planned surgeries or medical procedures. They can guide whether you should temporarily discontinue the medication and when it can be safely resumed.
Fact Box of Plegridy 125mcg Injection
Molecule name:Â Â Â Â Pegylated Interferon Beta-1a | Therapeutic class: Disease-Modifying Therapy |
Pharmacological class:Â Interferon | Indications:Â 1. Multiple sclerosis (MS) treatment 2. Relapse rate reduction 3. Delaying disability progression 4. Inflammation and immune modulation MRI lesion reduction 5. Alternative disease-modifying therapy (DMT) |
References
- National Institute for Health and Excellence, Peginterferon beta-1a for treating relapsing–remitting multiple sclerosis, [Revised on 19th Feb 2020] [Accessed on 16th Sept 2023], https://www.nice.org.uk/guidance/ta624/resources/peginterferon-beta1a-for-treating-relapsingremitting-multiple-sclerosis-pdf-82609017256645
- Biogen Idec Ltd, Electronic Medicines Compendium (EMC), [Revised on 26 Jul 2023] [Accessed on 16th Sept 2023], https://www.medicines.org.uk/emc/product/3409/smpc#gref
- PAUL R. LEE, US Food and Drug Administration[Revised on 29th Jan 2021 ] [Accessed on 16th Sept 2023],https://www.accessdata.fda.gov/drugsatfda_docs/appletter/2021/125499Orig1s021ltr.pdf
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