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Sorafenat 200mg Tablet 120's
Prescription Required
Salt Composition : Sorafenib
Manufacturer : NATCO PHARMA LTD
Origin of Medicine : India
120 Tablet(s) In A Bottle
Introduction to Sorafenat 200mg Tablet 120's
Sorafenat 200mg Tablet belongs to the anti-cancer group of medicines. It consists of the active ingredient Sorafenib, which is indicated for advanced renal cell carcinoma (kidney cancer), advanced hepatocellular carcinoma (liver cancer) in patients ineligible for surgery, and differentiated thyroid carcinoma (thyroid cancer) in patients who are not responsive to radioactive iodine therapy.
Diarrhea, tiredness, stomach pain, nausea, weakness, rashes, flu-like illness, appetite loss, nausea, weight loss, and low blood calcium levels are common side effects of Sorafenat 200mg Tablet. Inform your doctor if any of these side effects disturb or persist with you.
Inform your doctor if you are allergic to this tablet and its ingredients. Before starting treatment with this tablet, you should tell your physician if you have heart problems, chest pain, bleeding problems, high blood pressure, or have had or are about to have surgery. Use effective contraception during the therapy and for 6 months after the last dose if you are a woman or 3 months after the last dose if you are a man.
Uses of Sorafenat 200mg Tablet 120's
Sorafenat 200mg Tablet is used to treat:
- Advanced renal cell carcinoma
- Advanced hepatocellular carcinoma that cannot be surgically treated
- Advanced papillary and follicular Hurtle cell thyroid carcinoma
Therapeutic Effects of Sorafenat 200mg Tablet 120's
Sorafenat 200mg Tablet works by inhibiting multiple receptor tyrosine kinases (enzymes), primarily vascular endothelial growth factor receptors and platelet-derived growth factor-β receptors. This prevents the development of blood vessels in tumor cells (angiogenesis) and arrests the growth and spread of the tumor cells to other organs.
Interaction of Sorafenat 200mg Tablet 120's with other drugs
Inform your doctor about any prescribed medications, over-the-counter medicines, nutritional and vitamin supplements, or herbal products that you are taking or have taken before the treatment. Certain medications tend to interact with Sorafenat 200mg tablet and decrease its effectiveness.
More Information about Sorafenat 200mg Tablet 120's
- Store below 30°C in a dry place.
How to consume Sorafenat 200mg Tablet 120's
Take the Sorafenat 200mg tablet without food (1 hour before or 2 hours after a meal). Swallow with a glass of water. Do not break, crush or chew the tablets.
Safety Advices for Sorafenat 200mg Tablet 120's
Pregnancy
It is unsafe to use Sorafenat 200mg Tablet during pregnancy as it may harm the unborn baby. Inform your physician before starting this treatment if you are pregnant or think you might be pregnant. Your physician will conduct a pregnancy test before prescribing this medicine.
Breast Feeding
Do not breastfeed during treatment with Sorafenat 200mg Tablet and for two weeks after the last dose. It is vital to let your physician know if you are breastfeeding or planning to breastfeed before starting treatment with this drug.
Lungs
Sorafenat 200 mg tablet should be cautiously administered in patients with certain lung problems. Consult your doctor if you have any lung disorders.
Liver
Sorafenat 200 mg tablet should be taken with caution in patients with severe liver disease. Consult your doctor for advice.
Alcohol
Avoid drinking alcohol while taking Sorafenat 200mg Tablet as it can cause unpleasant side effects like drowsiness, dizziness, or difficulty in concentrating.
Driving
This medicine could cause peripheral sensory neuropathy that causes an impact on driving. Hence, avoid driving or doing things that require focus during this treatment period.
Side Effects of Sorafenat 200mg Tablet 120's
Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them.
Serious:
- Stevens Johnsons Syndrome and toxic epidermal necrosis
- Decreased blood flow to the heart
- Increased risk of bleeding (blood in urine, stool, vomit, cough, etc.)
- High BP
- Skin problems
- Liver problems
- Problems in wound healing
Common:
- Nausea, stomach pain, diarrhea
- Tiredness and weakness
- Infection
- Hair thinning and patchy hair loss
- Rash
- Weight loss
- Loss of appetite
- Low levels of calcium in the blood
- Flu-like illness
Word of Advice
It is advised to seek immediate medical attention if you have swelling in your lower legs, fast heartbeats, or trouble breathing. It may be a sign of heart problems. It may result in bleeding hence inform your doctor if you see blood in stools or urine.
FAQs
Q 1. Can a diabetic person take Sorafenat 200mg Tablet?
Yes, Sorafenat 200mg Tablet is safe to be taken by diabetic individuals. However, only take it after seeing a doctor, as they may change the dose based on the patient's condition.
Q 2. What are the conditions under which Sorafenat 200mg Tablet use is prohibited?
Sorafenat 200mg Tablet is not recommended for people who are allergic to any of its ingredients, have squamous cell lung cancer, or are already taking carboplatin and paclitaxel.
Q 3. When should I stop taking Sorafenat 200mg Tablet as a treatment?
Sorafenat 200mg Tablet should be discontinued if a person experiences a major adverse effect that impairs their quality of life. If not, you must continue taking this medication until your physician instructs you to stop.
Q 4. What class of medication is Sorafenat 200mg Tablet?
Sorafenat 200mg Tablet belongs to the group of medicines called anti-tumor and tyrosine kinase inhibitors.
Q 5. I am pregnant. Can I use Sorafenat 200mg Tablet during pregnancy?
Sorafenat 200mg Tablet should not be taken during pregnancy as it may harm the unborn baby. It is better to use effective contraceptive methods to prevent pregnancy while taking this medicine or for at least six months after taking the final dose.
Fact Box of Sorafenat 200mg Tablet 120's
Molecule name: Sorafenib
| Therapeutic class: Tyrosine kinase inhibitor |
Pharmacological class: Anti-Neoplastics | Indications: 1. Advanced renal cell carcinoma 2. Advanced hepatocellular carcinoma that cannot be surgically treated 3. Advanced papillary and follicular Hurtle cell thyroid carcinoma |
References
- Bayer (Pty) Ltd, [Revised on 22nd Apr 2016] [Accessed on 22 Nov 2022], https://www.bayer.com/sites/default/files/NEXAVAR_200_EN_PI.pdf
- Bayer HealthCare Pharmaceuticals Inc., US Food & Drug Administration, [Revised on Dec 2018] [Accessed on 22 Nov 2022]], https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/021923s020lbl.pdf
- Ciplamed, [Revised on Dec 2017] [Accessed on 22 Nov 2022]], https://www.ciplamed.com/print-product-pdf/24207
- Edward Chu, Cancer Chemotherapy, Lange’s Basic and Clinical Pharmacology, 14th Edition, 2018, 948-976.
- KD Tripathi, Anticancer Drugs, Essentials of Medical Pharmacology, 8th Edition, 2019, 915-936.
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