Uses of undefined

Leucovorin calcium/calcium folinate is used to prevent the harmful effects of methotrexate medicine when treating certain types of cancer. It is also used to treat people who have accidentally overdosed on methotrexate medicine or medications that belong to a similar class. It is also used with other anticancer medications to treat colorectal cancer (cancer that begins in the colon or rectum). Other uses include treating anemia caused by low levels of folic acid in the body.

undefined Drug administaration and Dosage available

Leucovorin calcium/calcium folinate is available as injection and tablet. The drug should be administered only by healthcare professionals experienced with cancer chemotherapy. Your physician will determine the dose and frequency of administration based on the type of cancer and severity of the disease. The medicine is administered either intravenously (into your vein) or intramuscularly (into your muscle) based on your disease condition. 

If you are prescribed tablets, then take the tablets as prescribed by your doctor. Do not break, crush, or chew the tablets. Swallow the tablet whole with a glass of water. It is important to take your medicine at the same time every day.

Warnings, Precautions and Side Effects of undefined

Warnings

This drug may cause hypercalcemia (high calcium levels in your blood). Notify your healthcare professional if you face any symptoms during or after the administration of the drug. Inform your physician immediately if you have diarrhea symptoms after administering leucovorin calcium/calcium folinate.

Precautions

Inform your physician if you have or ever had liver disease, kidney problems, heart problems, before starting the treatment with this medicine. Consult your doctor if you are pregnant, suspect pregnancy, or planning to become pregnant.  Do not take this medicine if you are allergic to leucovorin calcium, calcium folinate, or any of the other ingredients in it. Inform your healthcare provider about all the medicines you take, including prescription medications, over-the-counter medications, nutritional and vitamin supplements, and herbal products. Certain medications may interact with the effects of Leucovorin calcium/calcium folinate and reduce its effectiveness by causing undesirable side effects. Especially inform your physician if you are taking medications for seizures.

Side Effects

The common side effects include diarrhea, nausea, vomiting, inflamed and sore mouth, and tiredness. Serious side effects include allergic reactions like rash, low blood pressure, wheezing, shortness of breath, and swelling of the face or throat.

Word Of Advice

If you forgot your dosing schedule, inform your healthcare professional immediately and reschedule the dosing. Inform your doctor if you have vomited immediately after receiving the injection. If you accidentally take too much leucovorin calcium/calcium folinate, contact your doctor and seek medical advice immediately. Do not stop taking this medicine unless your doctor tells you to. Your physician may advise you to do regular blood tests to monitor your disease condition and the effectiveness of the treatment.

Frequently Asked Question

• What should I do if missed taking leucovorin calcium/calcium folinate?
• It is important to get leucovorin calcium/calcium folinate at the right time. If you missed your appointment, contact your healthcare provider and schedule your dosing immediately. Keep follow-ups on your next schedule.

• Why is leucovorin calcium/calcium folinate given 24 hours after methotrexate?
• Leucovorin calcium/calcium folinate is usually administered 24 hours after methotrexate so that it does not interfere with the therapeutic effect of methotrexate. It can also be used in methotrexate overdose; it should be administered as soon as possible.

• Can leucovorin calcium/calcium folinate cause swelling?
• Leucovorin calcium/calcium folinate may cause allergic reactions like rash, low blood pressure, wheezing, shortness of breath, and swelling of the face or throat.

• Can leucovorin calcium/calcium folinate cause seizures?
• There is no evidence that leucovorin calcium/calcium folinate cause seizures. But the medicine can affect the effect of seizure medication when administered concurrently. Inform your physician about all your medicines, including over-the-counter medications.

• How long does it take for leucovorin calcium/calcium folinate to work?
• Leucovorin calcium/calcium folinate starts acting on the body within 5 minutes of administration. However, this might vary with respect to dosage, the patient receiving the drug, and response to treatment.

• What measures should be taken to ensure the prompt excretion of methotrexate during treatment with leucovorin calcium/calcium folinate?
• A healthcare professional will monitor you during the treatment with this medicine. Maintenance of urine output above 2,500 mL/24hr in adults by increasing oral or intravenous fluids 12 hours before and for 36 hours after the end of methotrexate infusion. To monitor the alkalinization of urine (this enhances drug excretion) so that the urinary pH is greater than 7.0 before methotrexate infusion. Foods, drinks, and drugs that may increase urinary acidity should be avoided during the therapy. Finally, blood methotrexate concentration should be measured at least 24, 48, and 72 hours after the initiation of the methotrexate infusion.