This page contains brief details about the drug , it's indication, dosage & administaration, mechanism of action, related brands with strength, warnings and common side effects.

Background and Date of Approval

The U.S. FDA approved crisaborole in 14th Dec 2016, to treat mild to moderate atopic dermatitis (itchy inflammation of the skin) in adult and patients with two years of age.

Mechanism of Action of undefined

Crisaborole inhibits phosphodiesterase 4 (PDE-4), results in increased intracellular cyclic adenosine monophosphate (cAMP) levels, and suppresses the release of pro-inflammatory factors, which is responsible for atopic dermatitis.

Uses of undefined

Crisaborole is used to treat mild to moderate atopic dermatitis (itchy inflammation of the skin) in adults and patients with two years of age.

undefined Drug administaration and Dosage available

Always use this medicine exactly as your doctor has told you. Application sites are upper arms and shoulders. Your physician will decide the correct dosage and duration based on age, body weight, and disease condition.

Warnings, Precautions and Side Effects of undefined

Warnings

 Inform your doctor if you are allergic to crisaborole or any of the ingredients present in them. It is recommended to avoid swimming or bathing at least for 4 hours after the application of crisaborole. It is recommended only for external use (applied on skin).

Precautions

Inform your doctor if you have any skin problems before applying the ointment. Consult your doctor if you are planning to get pregnant or think you may be pregnant while breastfeeding. If you experience hives, swelling, or erythema at the application site, it is recommended to stop the ointment usage and consult your doctor immediately.

Side Effects

The common side effects that are experienced while you are on the treatment with crisaborole are pain at the application site (burning or stinging), hives, itching, swelling and redness.

Word Of Advice

Don't apply this ointment on damaged or affected skin, eyes, or mouth. If you accidentally apply it to your eyes. Wash your eyes with clean water and consult your doctor if you feel eye irritation even after washing your eyes. Don't forget to wash your hands before and after the application of the ointment. It is recommended to avoid swimming or bathing at least for 4 hours after the application of crisaborole.

Frequently Asked Question

References

  1. Vianex SA., Electronic Medicines Compendium (EMC), [Revised on May 2022] [Accessed on 20th Oct  2023], crisaborole 40mg/ml Injection - Patient Information Leaflet (PIL) - (emc) (medicines.org.uk)
  2. Fresenius Kabi USA, Inc., US Food and Drug Administration, [Revised on April 2021], [Accessed on 20th Oct 2023], https://www.accessdata.fda.gov/drugsatfda_docs/label/2021/050789s012lbl.pdf
  3. KD Tripathi, Essentials of Medical Pharmacology, Drugs acting on central nervous system, 2019, 795-799.

Disclaimer

The drug information on this page is not a substitute for medical advice, it is meant for educational purposes only. For further details consult your doctor about your medical condition to know if you are eligible to receive this treatment.