Uses of undefined

Dolutegravir, Lamivudine and Tenofovir disoproxil Fumarate has been developed to treat Human Immunodeficiency Virus (HIV-1). Dolutegravir, Lamivudine and Tenofovir disoproxil Fumarate Tablet is indicated as a complete regimen for treating adults and children infected with HIV 1.

undefined Drug administaration and Dosage available

Dolutegravir, Lamivudine and Tenofovir disoproxil fumarate is available as film coated tablets consisting of 50mg of Dolutegravir, 300mg of Lamivudine and 300mg of Tenofovir disoproxil fumarate. The usual recommended dosage of this combination regimen is one tablet everyday with or without food.

Warnings, Precautions and Side Effects of undefined

Warnings

Do not take this medication if you have experienced hypersensitivity reactions to Dolutegravir, lamivudine or Tenofovir disoproxil fumarate. Patients who are diagnosed with pancreatitis or at risk of pancreatitis should take this combination medicine with caution. During the Dolutegravir, Lamivudine and Tenofovir disoproxil Fumarate Tablet treatment, your doctor may periodically monitor your blood counts, bone mineral density, liver and kidney parameters to prevent serious complications. Report to your doctor if you have had a history of heart failure, pancreatitis, bone disease, fractures, liver or kidney problems.

Precautions

Adults of childbearing potential should consider using an effective contraceptive to prevent unwanted pregnancy. If you are pregnant or think you might be pregnant, your physician might suggest an alternative treatment as this combination regimen is not recommended during early pregnancy. Breastfeeding is not recommended due to potential transmission of HIV from mother to the baby.

Side Effects

The common side effects that are likely to occur while you are on the treatment with Dolutegravir, Lamivudine and Tenofovir disoproxil Fumarate Tablet are insomnia, tiredness, headache, diarrhoea, rash, pain, depression, cough and fever. Some serious adverse reactions include bone loss, worsening of Hepatitis B, kidney injury, immune reconstitution syndrome, lactic acidosis, and severe hepatomegaly. If you experience any allergic reactions after taking this tablet, report to your doctor immediately.

Word Of Advice

Dolutegravir, Lamivudine and Tenofovir disoproxil Fumarate can make you feel tired. Hence, you should avoid driving or handling machines during this treatment.

Frequently Asked Question

• What should you not take with Dolutegravir, lamivudine and tenofovir disoproxil fumarate?
• It is not recommended to take dolutegravir, lamivudine and tenofovir disoproxil fumarate tablet with dofetilide.

• Is it safe to use Dolutegravir, Lamivudine and Tenofovir disoproxil Fumarate Tablet during pregnancy and breastfeeding?
• If you are pregnant or think you might be pregnant, your physician might suggest an alternative treatment as this combination regimen is not recommended during early pregnancy. Breastfeeding is not recommended due to potential transmission of HIV from mother to the baby. 

• When should you report to your healthcare provider?
• Reach out to your healthcare provider if you experience symptoms of hypersensitivity reactions or lactic acidosis.

• What are the required laboratory parameters prior to starting this treatment?
• If you are an adolescent or adult of childbearing potential, your healthcare provider will perform pregnancy test before prescribing this treatment. other prominent tests include test for HBV infection, serum creatinine, estimated creatinine clearance, urine glucose and urine protein.

• How do you know if you are hypersensitive to Dolutegravir, Lamivudine or Tenofovir disoproxil fumarate?
• Watch out for symptoms like severe rash, rash accompanied by fever, muscle pain, extreme tiredness, facial edema, breathing difficulty, blisters and peeling of skin and reach out to your healthcare provider immediately if you experience any of these symptoms.

• What are some of the long-term side effects of this combination regimen?
• Some serious side effects of this combination regimen include worsening of hepatitis B, bone loss, kidney injury, pancreatitis, immune reconstitution syndrome, liver toxicity and hypersensitivity reactions.

• What are the symptoms of lactic acidosis?
• Unusual weakness, tiredness, muscle pain, trouble breathing, stomach pain, nausea, vomiting, dizziness, lightheadedness, irregular heartbeat and feeling cold especially in your arms and legs are the most prominent symptoms of lactic acidosis.