Esomeprazole+levosulpiride is a combination medication approved for medical use to treat gastroesophageal reflux disease.

Esomeprazole, a proton pump inhibitor, reduces stomach acid, relieving heartburn symptoms and promoting esophageal healing. Levosulpiride, an antipsychotic and prokinetic agent, affects dopamine receptors. Together, they lower acid production, aiding healing and preventing damage in the esophagus.

Esomeprazole+levosulpiride is available as tablets and capsules for oral intake. Your physician will decide the correct dosage and duration based on age, body weight, and disease condition.

The side effects known to occur commonly during the treatment with esomeprazole+levosulpiride are headache, stomach pain, accumulation of gas, nausea, vomiting, constipation, diarrhea and benign polyps in the stomach (masses of cells form in the stomach lining).

If you have known allergies to this drug or its components, it is not suitable for you. Using Esomeprazole+levosulpiride may worsen your urinary retention, making it difficult to empty your bladder. Be cautious if you have this issue, and if urinary retention happens, your doctor might consider stopping the treatment. Make sure to tell your doctor about any kidney or liver problems you have. They might give you a low dose and conduct regular blood tests to monitor your condition.

It is generally recommended to avoid using esomeprazole+levosulpiride during pregnancy unless it is necessary. Taking this drug while breastfeeding is unsafe because it may affect the child. Do not breastfeed while taking this medicine. This tablet does contain lactose, and if you have been diagnosed with a rare hereditary problem of galactose intolerance, glucose-galactose malabsorption, or Lapp lactase deficiency, it is advised not to use this medication.

Take the esomeprazole+levosulpiride tablets, exactly as your physician prescribes. Do not change the dose or stop taking the medication without consulting your doctor first. This drug is usually taken at least one hour before meals. Follow the general instructions given by your doctor regarding the timing and dosing of the medication. While taking this medicine, making certain dietary modifications to support your treatment may be helpful. Avoid foods and beverages that trigger your symptoms, such as spicy or acidic foods, caffeine, and alcohol. Eat smaller meals and avoid eating close to bedtime. Consider elevating the head of your bed to help reduce nighttime acid reflux.

1. Soigner Pharma, Manufacturer, [Accessed on 07 Oct 2023], https://www.soignerpharma.com/product/esperam-ls/
2. La Renon Healthcare Pvt Ltd., [Revised on 2018] [ Accessed on 07 Oct 2023], https://www.larenon.com/wp-content/uploads/2018/10/ESOGRESS.pdf
3. I.D. Penman, C.W. Lees, Alimentary tract and pancreatic disease, Davidson’s Principles & Practice of Medicine, 22nd Edition, 2014, 837-920.

The drug information on this page is not a substitute for medical advice; it is meant for educational purposes only. For further details, consult your doctor about your medical condition to know if you are eligible to receive this treatment.