This page contains brief details about the drug , it's indication, dosage & administaration, mechanism of action, related brands with strength, warnings and common side effects.

Background and Date of Approval

Granulocyte colony-stimulating factor is a hemopoietic drug developed by the U.S. Food And Drug Administration and initially approved in 1991 for treating Chemotherapy-induced neutropenia.

Mechanism of Action of undefined

Granulocyte Colony-Stimulating Factor (G-CSF) works by stimulating the bone marrow to produce and release white blood cells, specifically granulocytes, into the bloodstream. This increase in white blood cell production helps strengthen the body's immune response, making it particularly valuable in treating conditions where a higher white blood cell count is needed, such as during chemotherapy or in cases of neutropenia (low white blood cell count).

Uses of undefined

Granulocyte colony-stimulating factor is used to treat chemotherapy-induced neutropenia (a condition caused by abnormally low levels of neutrophils), fever and infection. Chemotherapy often leads to a drop in white blood cell counts, making patients susceptible to infections. This drug mainly helps to mitigate this risk by stimulating the production of white blood cells, reducing the chances of infection and treatment interruptions.

undefined Drug administaration and Dosage available

Granulocyte colony stimulating factor can be administered subcutaneously (under the skin) or intravenously (into a vein). The choice of administration method depends on the specific medical condition and treatment plan.

Warnings, Precautions and Side Effects of undefined

Warnings

If your WBC decreases, your body may not have enough cells to combat bacteria, putting you at risk of infection. Inform your physician if you have or had liver disease, kidney problems, sickle cell anemia or bone disease.

Precautions

Common side effects include fever, pain, rash, cough, shortness of breath, and nosebleeds. Granulocyte colony stimulating factor is contraindicated in individuals with known hypersensitivity or allergy to it or its component. 

Side Effects

The side effects known to occur commonly during the treatment with Granulocyte colony-stimulating factor are nausea, vomiting, headache, dizziness, decreased platelet, red blood cell count, diarrhea, unusual hair loss, troubled sleeping, inflammation of the lung, loss of appetite, constipation, pain when passing urine, muscle spasm, and nosebleeds. Some serious side effects include sudden signs of allergy (rash, itching, swelling of lips, tongue, wheezing), acute respiratory syndrome (cough, fever together with troubled breathing), enlargement of the spleen (pain in the upper left belly, pain below the left rib cage, pain at the tip of the shoulder), blood poisoning (combination of very cold, high heart rate, confusion, shortness of breath, sweaty skin, and extreme pain), capillary leak syndrome (puffiness, abdominal swelling, and feeling of fullness, difficulty breathing, and tiredness), and kidney injury (puffiness in face or ankles, blood in urine or brown-colored urine).

Word Of Advice

Individuals should monitor their temperature regularly, as Granulocyte colony stimulating factor can increase the risk of fever and infection. Notify your physician if a fever develops. Include a balanced diet rich in nutrients to support the immune system. If appetite is affected, consider consulting a nutritionist for dietary recommendations.

Frequently Asked Question

References

  1. Amgen Europe BV, Electronic medicines compendium (EMC), [ Revised on July 2022] [ Accessed on 2 Sep 2023], https://www.medicines.org.uk/emc/files/pil.3000.pdf
  2. Amgen, US Food and Drug Administration, [ Revised on March 2015] [Accessed on 2 Sep 2023], https://www.accessdata.fda.gov/drugsatfda_docs/label/2015/103353s5183lbl.pdf
  3. KD Tripathi, Essentials of Medical Pharmacology, Anticancer drugs, 7th edition, 2013, 876.

Disclaimer

The drug information on this page is not a substitute for medical advice; it is meant for educational purposes only. For further details, consult your doctor about your medical condition to know if you are eligible to receive this treatment.