Uses of undefined

Natalizumab is a monoclonal antibody used primarily for treating multiple sclerosis (MS) and moderate to severe Crohn's disease. 

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Natalizumab should be taken exactly as prescribed by a healthcare professional. The route of administration for this medication is intravenous (IV) infusion. This means that the medication is delivered directly into the bloodstream through a vein. This medication is not available in oral form or as a subcutaneous injection.

Warnings, Precautions and Side Effects of undefined

Warnings

Natalizumab increases the risk of PML, a rare and potentially fatal brain infection. Serious infusion reactions, including anaphylaxis, can occur during or shortly after the infusion. It may cause liver injury, as indicated by elevated liver enzyme levels. This medication can increase the risk of serious infections, including opportunistic infections and reactivation of latent infections. Live vaccines should not be administered to patients receiving this medication due to potential interference with the immune response.

Precautions

Patients require close monitoring for symptoms, and treatment should be discontinued if PML is suspected. Patients require observation during and after the infusion. Regular liver function monitoring may be required. Patients should discuss all medical conditions and medications with their healthcare provider before starting Natalizumab to ensure safe and appropriate treatment. 

Side Effects

Natalizumab may cause various side effects. Common side effects include headache, fatigue, and upper respiratory tract infections. However, there are serious side effects, such as progressive multifocal leukoencephalopathy (PML), a rare but potentially fatal brain infection, and hypersensitivity reactions during or after infusion. Liver damage and an increased risk of infections are also possible. 

Word Of Advice

For Natalizumab, safe use is close monitoring for signs of progressive multifocal leukoencephalopathy (PML), a rare but serious brain infection, as well as hypersensitivity reactions during or after infusion. Regular liver function tests should be performed to detect any liver damage. Patients should be vigilant for signs of infections, and concomitant use with other immunomodulatory medications should be carefully considered. Prior screening for hepatitis B virus (HBV) is recommended, and live vaccines should not be administered during treatment. Pregnant or breastfeeding individuals should consult their healthcare provider before starting or continuing this medication. It is essential to discuss all medical conditions and medications with the healthcare provider to ensure the safe and appropriate use of this medication and to address any potential risks.

Frequently Asked Question

• Can I receive other vaccines while on Natalizumab?
• Discuss vaccination plans with your healthcare provider. Some live vaccines may not be recommended while on Natalizumab due to potential interactions.

• What should I do if I miss a dose of Natalizumab?
• Contact your healthcare provider to reschedule the missed dose. Do not double the dose to make up for the missed one.

• Can I travel while on Natalizumab treatment?
• Yes, you can travel while on Natalizumab treatment. However, ensure access to medical facilities in an emergency, and inform your healthcare provider of your travel plans.

• Is it safe to stop Natalizumab abruptly?
• Abruptly stopping Natalizumab is not recommended, as it can lead to rebound disease activity. If you and your healthcare provider decide to discontinue treatment, a proper plan and alternative therapy should be in place.

• Are there any specific dietary restrictions while on Natalizumab?
• There are no specific dietary restrictions associated with Natalizumab. However, maintaining a balanced diet is essential for overall health.

• What should I do if I experience an infusion reaction during treatment?
• If you experience an infusion reaction, alert the healthcare provider immediately. They will manage the symptoms and determine if further action is needed.