This page contains brief details about the drug , it's indication, dosage & administaration, mechanism of action, related brands with strength, warnings and common side effects.

Background and Date of Approval

Netilmicin was approved for medical use in 1981 to treat bacterial infections.

Mechanism of Action of undefined

Netilmicin works by binding tightly to specific parts of the bacterial ribosomes. This binding disrupts the decoding site, where the cell reads genetic information, leading to errors in the synthesis of proteins. As a result, the bacteria can't produce essential proteins for their growth, rendering them unable to function properly. This mechanism makes this aminoglycoside effective against bacterial infections.

Uses of undefined

Netilmicin treats bacterial infections of the urinary tract, blood, skin, soft tissues, abdomen, lungs, heart, bone, and joints. It is also used to treat infections of wounds, burns, and peri-operative infections (infections that occur around the time of surgery).

undefined Drug administaration and Dosage available

Netilmicin is available as an injection in three different strengths: 100mg, 200mg, and 300mg and is administered into your muscle (intramuscularly) or directly into your veins (intravenous). Your doctor will decide your most apt dosage based on age, body weight, and physical circumstances.

Warnings, Precautions and Side Effects of undefined

Warnings

Before taking netilmicin, individuals with kidney disorders, asthma, allergies, or neuromuscular disorders like myasthenia gravis (muscle weakness) should consult their physician. Additionally, pregnant or breastfeeding individuals must inform their healthcare provider before receiving this injection.

Precautions

During the course of treatment with netilmicin injection, observe key precautions. If pregnant or planning to conceive, consult your doctor due to potential fetal effects. Breastfeeding individuals should only use it if necessary and under medical guidance. Netilmicin is generally safe for respiratory infections, but consult your doctor for personalized advice. Those with severe liver disease need to inform their doctor, as netilmicin can impact liver function. Avoid alcohol during treatment to prevent exacerbating potential side effects on the liver and kidneys. If unsure about driving, consult your doctor, especially if experiencing drowsiness during the treatment.

Side Effects

Serious side effects of netilmicin include allergic reactions, which can manifest as severe symptoms requiring immediate medical attention. Common side effects encompass potential kidney and hearing problems. It's crucial to be vigilant for any signs of allergies, such as difficulty breathing or swelling, and to seek prompt medical advice for severe symptoms. Additionally, regular monitoring for kidney and hearing issues is advisable during the course of treatment with netilmicin injection. If any concerning symptoms arise, it is recommended to consult with healthcare professionals for appropriate guidance and intervention.

Word Of Advice

Netilimicin injections are known to cause hearing and kidney issues due to their toxicity. Hence, Your doctor may get regular blood, urine, or hearing tests while you are on this medication. Since age can affect kidney function, elderly patients are monitored for renal health during treatment. They might be prescribed smaller doses due to age and reduced kidney function. Even those with normal kidneys may experience hearing loss. For premature infants and neonates, due to immature renal capability, it could lead to longer drug presence and potential toxicity. Hence, it is used cautiously and prescribed only when considered essential by your doctor. Drink plenty of water during the treatment with this medication. Prioritize discussing these considerations with your healthcare provider before opting for this injection.

Frequently Asked Question

References

  1. National Center for Biotechnology Information; PubChem Compound Summary for CID 441306, Netilmicin; Accessed on 9/12/2023 https://pubchem.ncbi.nlm.nih.gov/compound/Netilmicin
  2. Goodman & Gilman’s, The Pharmacological Basis of Therapeutics, Aminoglycosides, 12th edition, 2011, 1517.
  3. KD Tripathi, Essentials of Medical Pharmacology, Aminoglycoside antibiotics, 7th edition, 2013, 749.

Disclaimer

 The drug information on this page is not a substitute for medical advice; it is meant for educational purposes only. For further details, consult your doctor about your medical condition to know if you can receive this treatment.