Uses of undefined

Propofol injection is used to cause partial or complete reversible loss of consciousness (adult or child over the age of 1 month) so that surgical procedures can be performed. It can also be used to induce sleep in patients(16 years or older) receiving artificial respiration in an Intensive Care Unit (ICU).

undefined Drug administaration and Dosage available

Propofol is available in two strengths: 10ml and 20ml vials.  It is injected into your vein, usually in the back of your hand or forearm.  Your doctor will decide the most suitable dosage based on your disease condition, age, and physical circumstances.

Warnings, Precautions and Side Effects of undefined

Warnings

Do not take this medication if you are allergic to propofol, its ingredient, peanuts, or soya, as it contains soya oil. Before taking this medication, please inform your doctor, anesthetist, or nurse if you have a history of seizures, high blood fat levels, fat metabolism issues, dehydration, or any other health conditions related to your heart, lungs, kidneys, liver, or if you have experienced prolonged illness or have been diagnosed with mitochondrial disease. Sharing this information with your doctor ensures your treatment plan is tailored to your unique medical needs and safety.

Precautions

Regarding pregnancy, Propofol can potentially harm the baby and should only be used if deemed necessary by your doctor. Inform your doctor if you're pregnant, planning to become pregnant, or breastfeeding, as it can be excreted in breast milk and affect the baby. Be cautious with lung conditions, and inform your doctor if you have active lung disease. In rare cases, it may affect the liver, so discuss any liver problems with your doctor. Avoid alcohol while using propofol, and refrain from driving or operating machinery until the sedative effect disappears. Also, inform your doctor if you are taking other medications, particularly the antibiotic rifampicin (used for tuberculosis).

Side Effects

Serious adverse reactions to propofol may include sudden allergic responses, characterized by symptoms such as wheezing, difficulty in breathing, swelling of the eyelids, face, or lips, as well as rash or itching, especially when affecting the entire body. Additionally, stress cardiomyopathy may manifest with chest pain, shortness of breath, nausea, or an irregular heartbeat, particularly in high-stress situations. If you experience any serious or unusual reactions, it is essential to seek immediate medical attention.

The more common side effects are pain at the injection site, low blood pressure, alterations in breathing patterns, slow heartbeat, nausea, vomiting, headache, and, in children, withdrawal symptoms like unusual behavior, sweating, shaking, and anxiety, along with skin flushing.

Word Of Advice

Please inform your doctor if you are on a sodium-controlled diet or have allergies to peanuts or soya, as propofol injection contains these components. If the injection is administered over extended periods in intensive care, your doctor may prescribe a zinc supplement to prevent a decrease in your zinc levels. Before starting the treatment, it is essential to inform your doctor if you are allergic to any of these components or have any concerns.

It is essential to trust your medical team and communicate openly with them. Propofol is a powerful anesthetic used to induce and maintain anesthesia, and while it is generally safe, it is crucial to disclose your complete medical history, allergies, and any medications you are taking to your healthcare provider. Follow their instructions diligently, and inform them about any unusual sensations or discomfort during the procedure. It is natural to feel apprehensive, but focusing on the expertise of your medical team and openly communicating your concerns with your doctor can help ensure a safer and more comfortable experience. 

Frequently Asked Question

• How long does the effect of propofol injection last?
• The effect of propofol injection typically lasts for 24 hours, but this can vary from person to person, depending on the administered dose.

• Is propofol injection indicated for children?
• Propofol is not recommended to maintain anesthesia in children under one month.

• What should I take before getting my propofol injection?
• Adults and teenagers over 12 can eat solid foods and dairy products up to 8 hours before their hospital arrival time. Avoid alcohol within 8 hours of your appointment. You can have clear liquids, not dairy, up to 2 hours before surgery to stay hydrated.

• What restrictions should I follow after a propofol injection?
• It's important to avoid alcohol consumption during the treatment, as it may intensify the soothing effect. Additionally, do not operate a vehicle or heavy machinery since it causes severe drowsiness or dizziness, which may last several hours after the treatment.

• Can propofol injection cause dependence?
• As a sedative agent, propofol injection can potentially increase dependence and be subject to abuse. It is strictly not meant for self-administration and should only be administered by a healthcare provider. When used beyond the therapeutic dose, it can be life-threatening.

• Can propofol be taken orally? 
• No, propofol is typically administered as an injection because most of it is processed by the liver when taken by mouth. So, the usual method for receiving propofol is through an intravenous (IV) injection (into your veins) administered by a trained anesthesiologist.