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Acalnib 100mg Capsule
Prescription Required
Salt Composition : Acalabrutinib
Manufacturer : HETERO HEALTHCARE LTD
Origin of Medicine : India
30 Capsule(s) In A Bottle
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Introduction to Acalnib 100mg Capsule
Acalnib 100mg Capsule is an anticancer medicine containing the active constituent Acalabrutinib. It belongs to a class of drugs called Bruton's tyrosine kinase (BTK) inhibitors. It is used to treat mantle cell lymphoma (MCL), chronic lymphocytic leukemia (CLL), and small lymphocytic lymphoma (SLL). MCL, CLL, and SLL are cancers of the white blood cells called lymphocytes that are part of the immune system. They differ from each other by the location where cancer occurs and the type of lymphocytes affected.
Before taking this medicine, inform your doctor if you have had recent surgery, bleeding problems, heart rhythm problems, infection, are pregnant, or are breastfeeding. It is not recommended for children and adolescents less than 18 years. This medicine can increase the risk of bleeding. Patients taking Acalnib 100mg Capsule should be monitored for signs of bleeding and should avoid taking other medications that can increase the risk of bleeding, such as blood thinners.
Uses of Acalnib 100mg Capsule
The Acalnib 100mg Capsule is used in the treatment of
- Chronic lymphocytic leukemia
- Small lymphocytic lymphoma
- Mantle cell lymphoma
Therapeutic Effects of Acalnib 100mg Capsule
The therapeutic effect of Acalnib 100mg Capsule is to inhibit the activity of Bruton's tyrosine kinase (BTK), a protein that is essential for the survival and growth of cancer cells in certain types of lymphomas and leukemias. By blocking BTK, it can help to slow down or even stop the growth and spread of cancer cells, which can lead to a reduction in tumor size, an improvement in symptoms, and a delay in disease progression.
Interaction of Acalnib 100mg Capsule with other drugs
Inform your healthcare provider about all your medicines, including prescription, over-the-counter, nutritional or vitamin supplements, and herbal products. Certain medications may interact with Acalnib 100mg Capsule and reduce effectiveness by causing undesirable side effects.
More Information about Acalnib 100mg Capsule
- Store in a refrigerator between 20°C to 25°C (68°F to 77°F).
- Keep away from moisture, heat, and light.
- It should not be frozen.
- Keep it in its original packaging until it is ready to be used.
- Keep out of the reach of children and pets.
How to consume Acalnib 100mg Capsule
Acalnib 100mg Capsule is typically taken orally, with or without food. The tablets should be swallowed whole, not crushed, chewed, or broken. The recommended dosage can vary depending on the type of cancer being treated and other factors such as your overall health and response to treatment. Do not take a double dose to make up for a missed dose.
Safety Advices for Acalnib 100mg Capsule
Pregnancy
Acalnib 100mg Capsule is unsafe during pregnancy. It can harm the developing fetus, so pregnancy should be avoided while taking this medicine.
Breast Feeding
It is unknown whether Acalnib 100mg Capsule is excreted into human breast milk, so breastfeeding women should consult a doctor before taking it.
Lungs
If you have a lung disease or lung cancer and are considering treatment with Acalnib 100mg Capsule, it is important to discuss this medication's potential benefits and risks with your healthcare provider.
Liver
Acalnib 100mg Capsule can affect the liver, elevating liver enzymes (AST, ALT) in some patients taking it. In rare cases, severe liver injury or failure has been reported.
Alcohol
Patients taking Acalnib 100mg Capsules avoid or limit their alcohol consumption, as alcohol can exacerbate certain side effects of the medication, such as fatigue and depression.
Driving
Patients should always monitor their response to the Acalnib 100mg Capsule medication and be cautious when driving or operating machinery if they experience any side effects that may impair their ability to do so safely.
Side Effects of Acalnib 100mg Capsule
Like all medications, Acalnib 100mg Capsules cause some side effects, although not everyone will experience them.
Serious:
- Bleeding problems (bruising or bleeding)
- Infections (pneumonia and sepsis)
- High blood pressure
- Heart problems (irregular heartbeat and chest pain)
- Kidney failure
Common:
- Headache
- Diarrhea
- Nausea
- Fatigue
- Muscle and joint pain
- Bruising or bleeding easily
- Upper respiratory tract infection
- Rash or itching
Word of Advice
If you have been prescribed Acalnib 100mg Capsule, it is important to carefully read and understand the warnings and precautions associated with the medication. Patients require monitoring for signs of an allergic reaction. It can cause high blood pressure. Patients should check their blood pressure regularly. Report to your doctor if you develop a lesion or change in the appearance of an area on the skin. It increases the risk of infection, so patients should avoid close contact with infected persons. Patients with diabetes require close monitoring during treatment. Pregnancy and breastfeeding should be avoided during treatment. Always maintain a healthy and balanced diet to support your overall health and well-being.
FAQs
Q 1. Can I take Acalnib 100mg Capsule if I have a history of bleeding disorders?
Patients with a history of bleeding disorders may have an increased risk of bleeding while taking Acalnib 100mg of Capsule. Before starting treatment, your healthcare provider will evaluate your bleeding risk and may recommend additional monitoring or precautions.
Q 2. Can I take Acalnib 100mg Capsule if I have a history of heart disease?
Acalnib 100mg Capsule can cause cardiac effects, including irregular heartbeat and atrial fibrillation. Patients with a history of heart disease should be closely monitored while taking it. Your healthcare provider may recommend additional monitoring or precautions.
Q 3. How will this medication affect my blood?
Acalnib 100mg Capsule can affect your blood in several ways. It may cause a decrease in the number of red blood cells, white blood cells, and platelets. This can lead to anemia, infections, and an increased risk of bleeding. Your healthcare provider will monitor your blood counts before and during treatment.
Q 4. Can I take this medication if I have diabetes?
Acalnib 100mg Capsule can be taken by patients with diabetes, but it is important to monitor blood sugar levels closely while taking this medication. It can cause an increase in blood sugar levels in some patients, which may require adjustments in diabetes medications or insulin dosages.
Q 5. Can I go for Tooth extraction while taking this medication?
Patients taking Acalnib 100mg Capsule should inform their dentist and healthcare provider if they need to have a tooth extraction or any other dental procedures. This is because it can increase the risk of bleeding and impair wound healing. Your dentist and healthcare provider may recommend temporarily stopping treatment before the dental procedure to reduce the risk of bleeding.
Fact Box of Acalnib 100mg Capsule
Molecule name: Acalabrutinib | Therapeutic class: Antineoplastic |
Pharmacological class: Bruton's tyrosine kinase (BTK) inhibitors | Indications: 1. Chronic lymphocytic leukemia 2. Small lymphocytic lymphoma 3. Mantle cell lymphoma |
References
- AstraZeneca, Electronica medicines compendium (EMC), [Revised on Dec 2020], [ Accessed on 5th May 2023], https://www.medicines.org.uk/emc/files/pil.11917.pdf
- AstraZeneca, US Food and Drug Administration, [ Revised on Oct 2017], [ Accessed on 5th May 2023], https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/210259s000lbl.pdf
- John C Byrd et al; Acalabrutinib monotherapy in patients with relapsed/refractory chronic lymphocytic leukemia: updated phase 2 results; Blood; Published on April 2020; [Accessed on5th May 2023]; https://pubmed.ncbi.nlm.nih.gov/31876911
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