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Actemra 200mg Injection
Prescription Required
Salt Composition : Tocilizumab
Manufacturer : CIPLA LTD
Origin of Medicine : Switzerland
1 Vial(s) Of 10ml
Introduction to Actemra 200mg Injection
Actemra 200mg injection contains an active component called tocilizumab. This medicine belongs to a group of monoclonal antibody (a protein made from specific immune cells). This is used in conditions such as moderate to severe active rheumatoid arthritis (RA) and who have inadequate response with other rheumatoid drugs, giant cell arteritis (disease in arteries), children with systemic juvenile idiopathic arthritis (sJIA), polyarticular juvenile idiopathic arthritis (pJIA) which result in the pain and swelling in one or more joints in children of 1 to 2 year and above. Â
Children with allergic reactions to ingredients and severe infections should consult their doctor before taking the medicine. Talk to your doctor immediately if you have any allergic reaction (difficulty with breathing, chest tightness rash, itching, hives, swelling lips, tongue, or face), infection (short- or long-term), tuberculosis, intestinal ulcers or diverticulitis (small bulging pouches developed in the digestive tract), liver disease, cancer, kidney function problems, and persistent headaches. Â
Inform your doctor if the Children have a history of macrophage activation syndrome (activation and uncontrolled proliferation of specific blood cells). The elderly are more likely to develop infections than the general population, so it is important to be cautious when treating them. Consult your doctor if you are planning to get pregnant or think you may be pregnant or while you are breastfeeding.
Uses of Actemra 200mg Injection
- Rheumatoid arthritis
- Giant cell arteritis (GCA)
- Polyarticular Juvenile Idiopathic Arthritis (pJIA)
- Systemic Juvenile Idiopathic Arthritis (sJIA)
- Cytokine release syndrome
Therapeutic Effects of Actemra 200mg Injection
Actemra 200mg injection inhibits the function of a particular protein known as interleukin-6, which plays a role in the body's inflammatory responses. By blocking this protein, it can help decrease inflammation within your body.
Interaction of Actemra 200mg Injection with other drugs
Inform your doctor about any prescribed medications, over-the-counter medicines, nutritional or vitamin supplements, and herbal products you take or have taken before the treatment. Certain medications may interact with actemra 200mg injection and can cause undesirable side effects.
More Information about Actemra 200mg Injection
- Protect from light and moisture
- Store at 2°C - 8°C
- Keep children away from the sight and reach of this medication.
How to consume Actemra 200mg Injection
Actemra 200mg injection will be administered to you by a healthcare professional in a hospital setting. It is usually administered in the vein (intravenous). Your doctor will decide the dose, route of administration, and frequency based on your disease condition and other factors.
Safety Advices for Actemra 200mg Injection
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Pregnancy
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Consult your healthcare provider if you plan to get pregnant. However, Actemra 200mg injection has not been given to expectant mothers, and it should only be used when the projected advantages outweigh any possible hazards to the fetus. Â
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Breast Feeding
 ÂIt is unknown whether actemra 200mg injection is excreted in breast milk. So, before starting the treatment, inform your doctor if you are breastfeeding. Consult your doctor for more information.
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Lungs
  It is unknown whether actemra 200mg injectionis safe for patients with lung problems. Inform your physician if you have any lung disease before starting the treatment. Contact your doctor if you experience any lung-related symptoms.
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Liver
  Inform your physician about any underlying liver disorders before taking actemra 200mg injection, as this medication should be used cautiously in liver disease patients.
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Alcohol
 ÂIt is unknown whether actemra 200mg injection is safe to consume alcohol under medication. So, it is recommended to consult your doctor before taking medicine.
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Driving
  Actemra 200mg injection may cause drowsiness in the patient while under medication. So, it is recommended to consult your doctor before handling vehicles and machinery.
Side Effects of Actemra 200mg Injection
Side effects are unwanted symptoms caused by medicines. Even though all medicines cause side effects, not everyone gets them.
Serious
- Allergic reaction (difficulty with breathing, chest tightness, rash, itching, hives, swelling in the lips, tongue, or face)
- Fever and chills
- Mouth or skin blisters
- Stomach acheÂ
Common
- Upper respiratory tract infections (cough, blocked nose, runny nose, sore throat and headache)
- High blood fat (cholesterol) levels
- Injection site reactions.
- Lung infection (pneumonia)
- Shingles (herpes zoster)
- Cold sores (oral herpes simplex), blisters
- Eye infection (conjunctivitis)
- Headache, dizziness, high blood pressure
- Mouth ulceration, stomach pain
- Fluid retention (edema) in the lower legs, weight increase
- Cough, shortness of breath
- Low white blood cell counts (neutropenia, leucopenia)
- Abnormal liver function tests (increased transaminases)
- Increased bilirubin shown by blood tests
- Low fibrinogen levels in the blood (a protein involved in blood clotting)
Word of Advice
Talk to your doctor if you have recently been vaccinated or are planning a vaccination because a certain vaccination (Live vaccine) should not be given while taking actemra 200mg injection. Your doctor will advise you to check the blood if you have low white blood cells, platelets, or elevated liver enzymes before giving you the medicine.
FAQs
Q 1. What precautions should I take while on actemra 200mg injection?
Be aware of any potential infections that could come up, and consult your doctor. Your doctor will advise you to check the blood test to check. Let them know if you're having any new or worse symptoms immediately.
Q 2. Can I drive when I take actemra 200mg injection?
It is recommended to avoid driving when you take the medicine, as it can cause drowsiness. Consult your doctor before driving.
Q 3. Can an elderly individual safely take actemra 200mg injection?
The elderly are more likely to develop infections than the general population, so it is important to be cautious and consult your doctor before taking the medicine.
Q 4. Can I take a vaccination while under actemra 200mg injection?
Talk to your doctor if you have recently been vaccinated or are planning a vaccination because a certain vaccination (Live vaccine) should not be given while taking tocilizumab medicine.
Q 5. What is the purpose of actemra 200mg injection in children?
It is used to treat children with systemic juvenile idiopathic arthritis (sJIA) and polyarticular juvenile idiopathic arthritis (pJIA), which result in the pain and swelling in one or more joints in children of 1 to 2 years and above.
Fact Box of Actemra 200mg Injection
Molecule name: Tocilizumab | Therapeutic class: Anti-inflammatory agents, Monoclonal antibodies |
Pharmacological class: Interleukin-6 (IL-6) receptor inhibitors | Indications: 1. Rheumatoid arthritis Giant cell arteritis 2. Polyarticular Juvenile Idiopathic Arthritis 3. Systemic Juvenile Idiopathic Arthritis 4. Cytokine release syndrome |
References
- Roche Products Limited, Electronic Medicines Compendium (EMC), [Revised on Apr 2020] [Accessed on 26th Sep 2023], https://www.medicines.org.uk/emc/files/pil.13280.pdf
- Genentech, Inc., US Food and Drug Administration, [Revised on Aug 2017] [Accessed on 26rd Sep 2021], https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/125276s114lbl.pdf
- Ahmed A. Negm & Daniel E. Furst, Nonsteroidal Anti-Inflammatory Drugs, Disease-Modifying Antirheumatic Drugs, Nonopioid Analgesics, & Drugs Used in Gout, Lange’s Basic & Clinical Pharmacology, 14th Edition, 2018, 642-666.
Disclaimer
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