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Adalirel 20mg Injection
Prescription Required
Salt Composition : Adalimumab
Manufacturer : RELIANCE LIFE SCIENCES PVT LTD
Origin of Medicine : India
1 Prefilled Syringe(s) Of 0.4ml
Introduction to Adalirel 20mg Injection
Adalirel 20mg Injection contains the active ingredient Adalimumab. It is an antirheumatic agent that belongs to the class of medications called TNF (tumor necrosis factor) inhibitors. It is used alone or with other medications to relieve the symptoms of certain autoimmune disorders. It is used to treat rheumatoid arthritis (a condition in which the body attacks its joints, causing pain, swelling, and loss of function), polyarticular juvenile idiopathic arthritis (a condition that affects children in which the body attacks its own joints, causing pain, swelling, loss of function, and delays in growth and development).
It is also indicated to treat enthesitis-related arthritis, ankylosing spondylitis (a condition in which the body attacks the joints of the spine and other areas, causing pain and joint damage), axial spondyloarthritis without radiographic evidence of ankylosing spondylitis, psoriatic arthritis (a condition that causes joint pain and swelling and scales on the skin), plaque psoriasis, hidradenitis suppurativa (a skin disease that causes pimple-like bumps in the armpits, groin, and anal area), Crohn’s disease, ulcerative colitis (a condition which causes swelling and sores in the lining of the colon [large intestine] and rectum), and non-infectious uveitis (swelling and inflammation of different areas of the eye).
Do not use Adalirel 20mg Injection if you are allergic to adalimumab or any of the other ingredients present in this medicine. Do not take this medicine if you have active tuberculosis or other severe infections. Do not consume this medicine if you have moderate or severe heart failure. Inform your physician if you have any active infection before starting the treatment. Tell your doctor if you have lung problems, heart diseases, liver or kidney disorders before initiating the treatment. If you are pregnant, think you may be pregnant, or are planning to have a baby, ask your doctor for advice about taking this medicine.
Uses of Adalirel 20mg Injection
- Rheumatoid arthritis
- Polyarticular juvenile idiopathic arthritis
- Enthesitis-related arthritis
- Ankylosing spondylitis
- Axial spondyloarthritis without radiographic evidence of ankylosing spondylitis
- Psoriatic arthritis
- Plaque psoriasis
- Hidradenitis suppurativa
- Crohn’s disease
- Ulcerative colitis
- Non-infectious uveitis
Therapeutic Effects of Adalirel 20mg Injection
The active ingredient in this medicine is a human monoclonal antibody. Monoclonal antibodies are proteins that attach to a specific target. The target of Adalirel 20mg Injection is a protein called tumor necrosis factor (TNFα), which is involved in the immune (defense) system and at increased levels in the inflammatory diseases. By attaching to TNFα, Humira decreases inflammation in these diseases.
Interaction of Adalirel 20mg Injection with other drugs
Inform your healthcare provider about all the medicines you take, including prescription medications, over-the-counter medications, vaccines, nutritional and vitamin supplements, and herbal products. Certain medications interact with Adalirel 20mg Injection and reduce its effectiveness by causing undesirable side effects.
More Information about Adalirel 20mg Injection
- Store in a refrigerator (2°C – 8°C).
- Do not freeze.
- Protect the medicine from light and excessive moisture.
- Keep the medicine out of reach of children and pets
How to consume Adalirel 20mg Injection
Your doctor will decide the dose, duration, and frequency of administration based on your disease condition, severity and other factors. Always use this medicine exactly as your doctor or pharmacist has told you. Check with your doctor or pharmacist if you are not sure.
This medicine is to be administered by injection under the skin (subcutaneously). Your doctor or other healthcare professional will train you on how to use this injection. Do not self-administer this injection until you get trained. Your doctor will decide the dose, duration, and frequency of administration based on your disease condition, severeity and other factors.
Safety Advices for Adalirel 20mg Injection
Pregnancy
Do not take Adalirel 20mg Injection during pregnancy unless your doctor says. Inform your physician if you are pregnant, suspecting, or planning to get pregnant during the treatment. Use effective contraception during the treatment and for at least 5 months after the last dose.
Breast Feeding
Adalirel 20mg Injection can be used during breastfeeding. However, inform your physician if you are breastfeeding.
Lungs
Adalirel 20mg Injection should be taken cautiously in patients with lung problems. Inform your physician if you have any lung diseases before initiating the treatment.
Liver
Adalirel 20mg Injection should be taken cautiously in patients with liver problems. Inform your physician if you have any liver diseases before initiating the treatment.
Alcohol
It is unknown whether consuming alcohol is safe during the treatment with Adalirel 20mg Injection. Consult your doctor for more advice.
Driving
Adalirel 20mg Injection may have a small effect on your ability to drive, cycle or use machines. Room spinning sensation and vision disturbances may occur after taking this medicine
Side Effects of Adalirel 20mg Injection
Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them.
Common
- Injection site reactions
- Rash
- Headache
- Sinusitis
- Upper respiratory infections
- Fever
Serious
- Heart problems
- Abnormal heart beat
- Severe skin reactions
- GI bleeding
- Abnormal blood count values
- Liver injury
- Bone problems
- Infections
- Severe respiratory problems
Word of Advice
Certain vaccines may cause infections and should not be given while receiving this medicine; check with your doctor before you receive any vaccines. Inform your doctor if you have or have had a hepatitis B infection because this medicine may increase your chance of getting the infection again. You may be taught how to give your medicine at home. Make sure you understand all instructions before giving yourself an injection.
You will be shown the body areas where this shot can be given. Use a different body area each time you give yourself a shot. Keep track of where you give each shot to make sure you rotate body areas. Do not inject into skin areas that are red, bruised, tender, or hard. Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.
FAQs
Q 1. How long does it take for Adalirel 20mg Injection to start working?
The response to Adalirel 20mg Injection can vary among individuals and the condition being treated. Some individuals may experience improvement in symptoms within a few weeks, while others may take longer. It is important to follow the healthcare provider's instructions and allow sufficient time for the medication to take effect.
Q 2. Can Adalirel 20mg Injection increase the risk of infections?
Adalirel 20mg Injection may increase the risk of serious bacterial, viral, or fungal infections. It is essential to promptly report any signs of infection to a healthcare provider while taking this medicine. Inform your physician if you have or had any active infections.
Q 3. What are the common side effects of Adalirel 20mg Injection?
Common side effects of Adalirel 20mg Injection may include injection site reactions, such as pain, redness, or swelling. Other possible side effects include headaches, upper respiratory infections, nausea, and rash. Serious side effects are rare but can occur.
Q 4. How long can I take Adalirel 20mg Injection?
The duration of Adalirel 20mg Injection treatment can vary depending on the individual's condition and response to the medication. In some cases, this medicine may be used as a long-term maintenance therapy, while treatment duration may be shorter in other situations. It is important to follow the healthcare provider's guidance regarding the appropriate duration of treatment.
Q 5. Can Adalirel 20mg Injection be used in individuals with kidney or liver impairment?
Adalirel 20mg Injection may require dosage adjustments or caution in individuals with kidney or liver impairment. Healthcare providers will assess the patient's situation and determine the appropriate dosage based on renal and hepatic function.
Fact Box of Adalirel 20mg Injection
| Molecule name: Adalimumab | Therapeutic class: Antirheumatic agent, Monoclonal antibody |
| Pharmacological class: TNF inhibitors | Indications: 1. Rheumatoid arthritis 2. Polyarticular juvenile idiopathic arthritis 3. Enthesitis-related arthritis 4. Ankylosing spondylitis 5. Axial spondyloarthritis without radiographic evidence of ankylosing spondylitis 6. Psoriatic arthritis 7. Plaque psoriasis 8. Hidradenitis suppurativa 9. Crohn’s disease 10. Ulcerative colitis 11. Non-infectious uveitis |
References
- Goodman & Gilman’s, The Pharmacological Basis of Therapeutics, Immunosuppressants, tolerogens, and immunostimulants, 12th edition, 2011, 1018.
- KD Tripathi, Essentials of Medical Pharmacology, Antirheumatoid and antigout drugs, 7th edition, 2013, 213.
- AbbVie Ltd, Electronic medicines compendium (emc), [ Revised on April 2021] [ Accessed on July 2023], https://www.medicines.org.uk/emc/files/pil.2150.pdf
- AbbVie Inc, US Food and Drug Administration, [ Revised on Feb 2021] [ Accessed on July 2023], https://www.rxabbvie.com/pdf/humira.pdf
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