Adripeg 20mg Injection

• Metastatic Breast cancer
• Ovarian cancer
• Multiple myeloma
• AIDS-related Kaposi’s sarcoma

Polyethylene glycol (PEG)-coated liposomes allow enhanced tumor targeting and selective drug release within cancer cells. Doxorubicin, once internalized by cancer cells, intercalates into DNA strands and inhibits transcription and DNA replication, as well as disrupting the topoisomerase II enzymes that are important in DNA repair processes. This causes cancer cells to undergo apoptosis, cell cycle arrest, and DNA damage. Furthermore, doxorubicin produces reactive oxygen species (ROS), which exacerbates oxidative stress and accelerates the death of tumor cells.

The unique formulation process of Liposomal Doxorubicin Injection increases the time this medicine is circulating in the blood. It also helps deliver drugs from blood to the cancerous tissue rather than the healthy tissue.

Inform your doctor about any medications you take or have taken before the treatment, including prescription, over-the-counter, nutritional or vitamin supplements, and herbal products. Certain medications may interact with pegylated liposomal doxorubicin and can cause undesirable side effects.

• Keep the injection out of sight and reach of children.
• Store refrigerated at 2°C - 8°C. Do not freeze.
• Protect the medicine from light and excessive moisture.
• Keep the medicine out of reach of children and pets
• If you forgot to take the injection, inform your healthcare professional immediately and reschedule the appointment.

Your doctor will give you an infusion injection (drip) of  Adripeg 20mg Injection into a vein. This could take anywhere from 30 minutes to more than an hour, depending on the dosage and condition. Your dose and frequency of administration will be decided by your physician based on your disease condition and other factors. It will be given to you by a healthcare professional. Do not self-administer.

Side effects are unwanted symptoms caused by medicines. Even though all medicines cause side effects, not everyone gets them. 

Serious

• Severe diarrhea, sores in mouth, nausea, vomiting
• Hand foot syndrome
• Lung infections, shortness of breath
• Severe stomach pain
• Seizures
• Severe weakness
• Tachycardia

Common

• Low blood cell counts
• Hair loss
• Decreased appetite
• Skin rashes
• Pain in the muscles and joints
• Constipation
• Conjunctivitis
• Feeling confused, difficulty sleeping
• Headache, dizziness, sleepiness
• Change in taste
• High or low blood pressure
• Excessive sweating
• Pain when passing urine
• Weight loss
• Muscle spasms

It is not recommended to use this drug if you are allergic to the active compound pegylated liposomal doxorubicin and its components. It is also not recommended for use if you are allergic to products like pea and soy.  Blood glucose levels, blood pressure, and liver and kidney function should be monitored regularly while taking this medication. Don't stop this medication without the proper advice of the doctor. It is recommended to monitor your liver, heart and lung functions during the treatment course. Avoid making plans for pregnancy or during pregnancy, as this medication can cause harmful effects on the developing baby. It is recommended to use effective contraceptive measures during the treatment and up to 8 months after the treatment has been withdrawn. Avoid driving after taking this medication because it causes dizziness and lack of concentration.

The drug may cause decreased bone marrow activity. Monitoring complete blood counts regularly during therapy and watching for infections is advisable.To manage the treatment related to diarrhoea it is recommended to drink at least 3 litres of water and it is advised to wear masks and stay indoors as this medication lowers the blood cell count that may decrease the immunity.