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Amphonat 50mg Injection
Prescription Required
Salt Composition : Liposomal Amphotericin B
Manufacturer : NATCO PHARMA LTD
Origin of Medicine : India
1 Vial(s)
Introduction to Amphonat 50mg Injection
Amphonat 50mg injection contains the active substance Liposomal Amphotericin B. It is an antifungal antibiotic. It is used to treat fungal infections of one or more deep body organs. It is also used to treat suspected fungal infections in patients with a raised temperature and neutropenia (reduced number of white blood cells). It is also indicated to treat visceral leishmaniasis, a disease caused by a parasite in certain people. Â
Before initiating your first treatment, your physician may give you a small amount of Amphonat 50mg injection to check for allergic reactions. Do not receive this injection if you are allergic to amphotericin B or any of the other ingredients in the medicine. Inform your physician if you have a severe allergic reaction, kidney or liver problems, and if you are having dialysis. Tell your doctor if you have low potassium levels.Â
This medicine contains sugar in each vial; tell your doctor if you have diabetes. Inform your physician if you are pregnant or breastfeeding before initiating the treatment. The most common side effects of Amphonat 50mg injection are skin rash, low potassium levels, diarrhea, anemia, insomnia, and shortness of breath. This medicine is not recommended for babies under 1 month old.
Uses of Amphonat 50mg Injection
- Fungal infections of one or more deep organs of the body
- Suspected fungal infections
- Visceral leishmaniasis
Therapeutic Effects of Amphonat 50mg Injection
Amphonat 50mg injection binds primarily to ergosterol in sensitive fungi cell membranes, causing membrane permeability changes that result in leakage of intracellular contents and cell death.Â
Interaction of Amphonat 50mg Injection with other drugs
Inform your healthcare provider about all the medicines you take, including prescription medications, over-the-counter medications, recent vaccinations, nutritional and vitamin supplements, and herbal products. Certain medications may interact with Amphonat 50mg injection and reduce its effectiveness by causing undesirable side effects.
More Information about Amphonat 50mg Injection
- Do not store above (25°C)
- keep the injection away from the reach of children and pets.
- If you have missed any dosing appointments, inform your doctor and schedule immediately.
How to consume Amphonat 50mg Injection
A doctor or nurse in a hospital or clinic setting will give it to you. It is given as an intravenous infusion drip (into your vein). Do not self-administer the injection. Your doctor will decide the dose and duration of the treatment based on your disease severity, body weight, and other factors.
Safety Advices for Amphonat 50mg Injection
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Pregnancy
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Inform your physician if you are pregnant, suspect pregnancy, or planning to become pregnant before receiving Amphonat 50mg injection.
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Breast Feeding
 ÂIt is unknown whether Amphonat 50mg injection is safe for breastfeeding women. Inform your physician if you are breastfeeding before initiating the treatment.Â
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Lungs
  It is unknown whether Amphonat 50mg injection can be used in patients with lung disorders. Consult your doctor if you have any lung diseases before starting the treatment.
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Liver
  It is unknown whether Amphonat 50mg injection can be used in patients with liver disorders. Consult your doctor if you have any liver problems before starting the treatment.
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Alcohol
 ÂIt is unknown whether consuming alcohol is safe during the treatment with Amphonat 50mg injection. Inform your doctor if you are a chronic drinker.
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Driving
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Amphonat 50mg injection may affect your ability to drive and operate machinery. Do not drive or use heavy machinery during the treatment.Â
Side Effects of Amphonat 50mg Injection
Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them.
Common
- Skin rash
- Increased blood sugar levels
- Decreased potassium levels
- Diarrhea
- Nausea, vomiting
- Anemia
- Insomnia
- Shortness of breath
- Fever, chills or shivering
Serious
- Cardia arrest
- GI bleeding
- Severe skin reactions
- Acute kidney injury
Word of Advice
This medicine may cause damage to the kidney. Inform your doctor if you have kidney problems. This injection may cause severe infusion reactions such as flushing, itching, sickness, swelling of the face, mouth, tongue and airways, difficulty breathing. Inform your physician immediately if you face any of these symptoms. It may be necessary to continue this medication for several weeks to several months in order to treat certain infections. Stopping the medication too early may result in a return of the infection.Tell your doctor if your condition lasts or gets worse.Â
FAQs
Q 1. What is Amphonat 50mg injection?
Amphonat 50mg injection is a medication used to treat severe fungal infections, such as invasive or systemic fungal infections. It is a lipid-based formulation of Amphotericin B, designed to enhance drug delivery and minimize side effects.
Q 2. What are the possible side effects of Amphonat 50mg injection?
While Amphonat 50mg injection is generally well-tolerated, it can still have side effects. Common side effects may include fever, chills, headache, nausea, vomiting, increased blood sugar levels, muscle or joint pain, and infusion-related reactions. In rare cases, it may cause more serious side effects such as cardiac arrest, kidney damage or allergic reactions.
Q 3. Can Amphonat 50mg injection be used in pediatric patients?
Amphonat 50mg injection can be used in babies more than 1 years old, but the dosage and administration may vary depending on the child's age, weight, and specific medical condition. It is crucial to follow the healthcare provider's instructions and closely monitor the child's response to treatment.
Q 4. Why is Amphonat 50mg injection less toxic?
Amphonat 50mg injection is less toxic because it is less nephrotoxic. Low toxicity of this medicine may be due to the small number of binding receptors in the drug.
Q 5. What are the advantages of using Amphonat 50mg injection over other antifungal medications?
One of the key advantages of Amphonat 50mg injection is its lower toxicity compared to conventional Amphotericin B. This makes it a preferred choice, especially for patients more susceptible to antifungal medications' side effects. Additionally, Amphonat 50mg injection has a prolonged circulation time in the body, allowing for less frequent dosing.
Fact Box of Amphonat 50mg Injection
Molecule name: Liposomal Amphotericin BÂ | Therapeutic class: Antibiotic |
Pharmacological class: Antifungals | Indications: 1. Fungal infections of one or more deep organs of the body 2. Suspected fungal infections 3. Visceral leishmaniasis |
References
- Goodman & Gilman’s, The Pharmacological Basis of Therapeutics, Chemotherapy of protozoal infections, 12th edition, 2011, 1424.
- KD Tripathi, Essentials of Medical Pharmacology, Antifungal drugs, 7th edition, 2013, 787-788.
- Gilead Sciences International Ltd, Electronic medicines compendium (emc), [ Revised on Sept 2020] [ Accessed on 11th June 2023], https://www.medicines.org.uk/emc/files/pil.1022.pdf
- Gilead Sciences, Inc, US Food and Drug Administration, [ Revised on Oct 2008] [ Accessed on 11th June 2023], https://www.accessdata.fda.gov/drugsatfda_docs/label/2008/050740s016lbl.pdf
Disclaimer
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