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Aplevant 0.75mg Injection
Prescription Required
Salt Composition : Dulaglutide
Manufacturer : LUPIN LTD
Origin of Medicine : India
2 Prefilled Syringe(s)
Introduction to Aplevant 0.75mg Injection
Aplevant 0.75mg Injection contains active component Dulaglutide. It is a medication that is used to treat type 2 diabetes. It belongs to a class of drugs called glucagon-like peptide-1 receptor agonists (GLP-1 RAs). Aplevant 0.75mg Injection works by mimicking the action of a hormone called glucagon-like peptide-1 (GLP-1) in the body. It is typically used in combination with other diabetes medications, such as metformin or sulfonylureas, when diet and exercise alone are not sufficient to control blood sugar levels. This medication improves glycemic control and helps prevent hyperglycemia (high blood sugar) and hypoglycemia (low blood sugar). Many people with type 2 diabetes struggle with weight management. This medication has been shown to promote weight loss or maintenance in some individuals. This can benefit overall health and contribute to better diabetes management.
It is administered once a week, making it a convenient treatment option compared to medications that require daily dosing. This can simplify the medication regimen for individuals with diabetes and improve treatment adherence. Aplevant 0.75mg Injection is contraindicated in individuals with known hypersensitivity or allergic reactions to it or its components. This medication should be avoided in individuals with a personal or family history of MTC (medullary thyroid cancer), a type of thyroid cancer. Tell your doctor if you have a history of pancreatic, eye, or kidney problems. The safety and efficacy in children and adolescents under the age of 18 have not been established. Therefore, Aplevant 0.75mg Injection is not recommended for use in this population.
Uses of Aplevant 0.75mg Injection
- Treatment of type 2 diabetes
Therapeutic Effects of Aplevant 0.75mg Injection
Aplevant 0.75mg Injection, a GLP-1 receptor agonist, improves glycemic control in individuals with type 2 diabetes by stimulating insulin secretion, suppressing glucagon release (a hormone that prevents excessive glucose production by the liver.), and slowing gastric emptying. These actions work together to lower blood sugar levels, promote weight loss or weight maintenance, and reduce appetite. By addressing multiple aspects of diabetes management, this medication offers a comprehensive therapeutic effect for individuals with type 2 diabetes.
Interaction of Aplevant 0.75mg Injection with other drugs
Inform the doctor about your medicines, including prescription, over-the-counter, nutritional or vitamin supplements, and herbal products. Certain medications may interact with the Aplevant 0.75mg Injection, reducing effectiveness by causing undesirable side effects.
More Information about Aplevant 0.75mg Injection
- Store in a refrigerator at 2-8°C.
- Keep away from moisture, heat, and light.
- It should not be frozen.
- Keep away from children and pets.
How to consume Aplevant 0.75mg Injection
Aplevant 0.75mg Injection is typically administered by a healthcare professional once in a week. It is usually given as an injection. The healthcare provider will determine the dosage and duration of treatment based on the specific infection and individual factors.
Safety Advices for Aplevant 0.75mg Injection
Pregnancy
The safety of Aplevant 0.75mg Injection use during pregnancy has not been established. If you are pregnant or planning to become pregnant, discussing the potential risks and benefits with your healthcare professional is essential.
Breast Feeding
Women should consult a doctor while breastfeeding while taking the Aplevant 0.75mg Injection.
Lungs
Suppose you have a pre-existing lung condition or are concerned about the safety of the Aplevant 0.75mg Injection in your lungs. In that case, consulting with your healthcare provider for personalized advice is recommended.
Liver
If you have a liver condition or are concerned about the safety of Aplevant 0.75mg Injection, it is recommended to consult your healthcare provider for personalized advice.
Alcohol
It is generally advisable to avoid consuming alcohol while taking Aplevant 0.75mg Injection. Alcohol can impair the body's immune system, making it less effective in fighting infections.
Driving
People may experience side effects, including dizziness, drowsiness, or fatigue, after using Aplevant 0.75mg Injection. In that case, avoid driving or operating heavy machinery.
Side Effects of Aplevant 0.75mg Injection
Aplevant 0.75mg Injection cause some side effects like all medications, although not everyone will experience them.
Serious
- Pancreatitis (inflammation of the pancreas)
- Thyroid C-cell tumor (type of thyroid cancer)
Common
- Nausea
- Vomiting
- Diarrhea
- Abdominal pain
Word of Advice
Before receiving the Aplevant 0.75mg Injection, inform your healthcare provider about any known allergies, previous adverse reactions. Be aware of adverse side effects and seek immediate medical attention if any of them occur. Take precautions when using it, such as monitoring renal function if you have moderate to severe renal impairment and when combining this medication with insulin secretagogues or insulin to prevent hypoglycemia. If you have a history of cardiac arrhythmias or unstable cardiovascular disease, close monitoring may be necessary due to its possible increased heart rate. Follow proper injection technique and site rotation to minimize the risk of injection site reactions. If you are pregnant or breastfeeding, carefully weigh this medication potential risks and benefits with your healthcare professional. Be vigilant, communicate openly with your healthcare professional, and promptly report any unusual symptoms or concerns while taking it.
FAQs
Q 1. Can Aplevant 0.75mg Injection be used in people with type 1 diabetes?
No, Aplevant 0.75mg Injection is specifically approved for treating type 2 diabetes and should not be used in people with type 1 diabetes. It works by stimulating the release of insulin from the pancreas in response to high blood sugar levels, which is not applicable in type 1 diabetes, where there is a lack of insulin production.
Q 2. Can Aplevant 0.75mg Injection be used in elderly patients?
Aplevant 0.75mg Injection can be used in elderly patients with type 2 diabetes. However, caution should be exercised due to the potential increased risk of renal impairment or other age-related conditions. Close monitoring of renal function and overall health is advised, and individualized treatment decisions should be made in collaboration with the healthcare professional.
Q 3. Can Aplevant 0.75mg Injection cause weight loss?
Aplevant 0.75mg Injection has been associated with weight loss in some individuals with type 2 diabetes. The exact mechanisms are not fully understood, but it is believed to be related to how this medication affects appetite and digestion. However, the extent of weight loss can vary among individuals, and not everyone will experience significant weight loss.
Q 4. Can Aplevant 0.75mg Injection be used in people with kidney disease?
Aplevant 0.75mg Injection should be used cautiously in individuals with moderate to severe kidney impairment. Close monitoring of renal function is necessary, and the dosage may need to be adjusted based on kidney function. Discussing your kidney health with your healthcare professional before initiating it.
Q 5. Can Aplevant 0.75mg Injection be used in people with a history of cardiovascular disease?
Individuals with a history of cardiovascular disease can generally use Aplevant 0.75mg Injection, but close monitoring may be required due to potential cardiovascular effects. Discussing your history of heart-related conditions with your healthcare professional to determine the most appropriate treatment approach is important.
Q 6. What are the side effects of Aplevant 0.75mg Injection?
Common side effects of Aplevant 0.75mg Injection include gastrointestinal disturbances such as nausea, vomiting, diarrhea, and abdominal pain. Less common but more serious side effects can include pancreatitis, characterized by severe abdominal pain, and allergic reactions such as anaphylaxis. Other potential side effects include thyroid C-cell tumors, injection site reactions, and an increased heart rate.
Fact Box of Aplevant 0.75mg Injection
Molecule name: Dulaglutide | Therapeutic class: Antidiabetic |
Pharmacological class: Glucagon-like peptide-1 receptor agonists | Indications: Type 2 Diabetes |
References
- Eli Lilly and Company Limited, Electronic medicines compendium (EMC), [Revised on 25th May 2023], [Accessed on 31st May 2023], https://www.medicines.org.uk/emc/files/pil.3634.pdf
- Eli Lilly and Company, US Food and Drug Administration, [Revised on January 2017] [Accessed on 1st June 2023], https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/125469s007s008lbl.pdf
- KD Tripathi, Essentials of Medical Pharmacology, 2018, 8th Edition, 1002.
Disclaimer
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