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Azishil 100mg Injection
Prescription Required
Salt Composition : Azacitidine
Manufacturer : SHILPA MEDICARE LTD
Origin of Medicine : India
1 Vial(s)
Introduction to Azishil 100mg Injection
Azishil 100mg injection is used for treating adults with Myelodysplastic syndrome (MDS) and Acute myeloid leukemia (AML) if they are considered ineligible for stem cell transplant. In Myelodysplastic Syndrome, the bone marrow does not produce healthy blood cells due to its lack of function. Acute Myeloid Leukemia is a type of bone marrow cancer that is caused by the release of incompletely formed blood cells into the bloodstream.
Do not take Azishil 100mg injection if you are allergic to any of the other ingredients in the drug. Inform your physician about your medical and medication history before initiating the treatment. Tell your physician if you are pregnant, breastfeeding, or planning to get pregnant before taking this medicine.
Uses of Azishil 100mg Injection
- Treatment of Acute Myeloid Leukemia with 20-30% blasts in patients who are not eligible for Haemopoietic stem cell transplant
- Intermediate-2 and High-risk Myelodysplastic syndrome (MDS)
Therapeutic Effects of Azishil 100mg Injection
In MDS and AML, the development of tumor cells is caused by the process of transcriptional repression of various genes, which is due to hypermethylation of DNA. Transcriptional repression is a process where proteins bind directly or indirectly to DNA and control the activity of copying a specific gene or a set of genes. The active form of Azishil 100mg injection binds to RNA and DNA, interrupts their activity in actively multiplying cells and exhibits a toxic effect on cancer cells.
Interaction of Azishil 100mg Injection with other drugs
Inform your healthcare provider about all the medicines you take, including prescription medications, over-the-counter medications, nutritional and vitamin supplements, and herbal products. Certain medications interact with Azishil 100mg Injection and reduce their effectiveness by causing undesirable side effects.
More Information about Azishil 100mg Injection
- Store the medicine below 30℃.
- Protect the medicine from light and excessive moisture.
- Keep the medicine out of reach of children and pets.
How to consume Azishil 100mg Injection
Take Azishil 100mg injection only under the supervision of your physician. Your physician will decide the dose based on your height, weight and general condition. Azishil 100mg injection shall be given under the skin of your thigh, stomach or upper arm.
Safety Advices for Azishil 100mg Injection
Pregnancy
Azishil 100mg injection could be harmful to the unborn fetus. Inform your physician if you are pregnant or planning to get pregnant.
Breast Feeding
Breastfeeding is not intended for patients on Azishil 100mg injection therapy. Consult your physician for advice.
Lungs
It is not known whether it is safe to administer Azishil 100mg injection in lung failure patients. Please consult your doctor.
Liver
Inform your physician if you have been told that you have a tumor in the liver cells.
Alcohol
It is not known whether it is safe to consume alcohol with Azishil 100mg injection. Please consult your doctor.
Driving
It is unsafe to drive after taking this injection as it causes dizziness and patients lack concentration and alertness. So, avoid driving and handling heavy machinery after taking Azishil 100mg injection.
Side Effects of Azishil 100mg Injection
Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them.
Serious:
- Unexpected bleeding, with blood in stool and urine
- Fever
- Pneumonia, characterized by chest pain or breathlessness.
- Allergic reaction with symptoms of swelling of lips, itching or rashes.
- Seizures, loss of consciousness, severe headache or bleeding in the brain
- Frequent urination with pain or burning sensation
Common:
- Disturbances in the blood count (RBC, WBC, Platelets)
- Nausea, vomiting, diarrhea
- Constipation
- Tiredness
- Skin reaction like redness and pain at the site of injection
- Decreased appetite
- Dizziness
- Pain in extremities
- Joint pain
- Stomach pain
- Headache
- Sore nose and throat
- Rashes and bruising
Word of Advice
Inform the doctor if the patient has any allergy reactions, respiratory problems,kidney, liver, heart problems and medication taken for different medical conditions before taking this injection as they worsen the condition. Avoid using this injection if the patient is planning for pregnancy or during pregnancy and in breast feeding mothers as this medicine causes harmful effects in the developing baby. Take this injection only under the supervision of the physician. Doctors will decide the dose based on the patient's height, weight and general condition. It is administered under the skin of your thigh, stomach or upper arm.
FAQs
Q 1. How to use Azishil 100mg injection?
Take only under the supervision of the physician. Doctor’s will decide the dose based on patients height, weight and general condition. Azishil 100mg injection is administered under the skin of your thigh, stomach or upper arm.
Q 2. Does Azishil 100mg injection cause hair loss?
No, Azishil 100mg injection does not cause hair loss even after using it for a prolonged period of time.
Q 3. How does Azishil 100mg injection?
Azishil 100mg injection binds to RNA and DNA, interrupts their activity in actively multiplying cells and exhibits a toxic effect on cancer cells.
Q 4. Is Azishil 100mg injection chemotherapy?
Yes. Azishil 100mg injection is chemotherapy and it is used in the treatment of cancers. It interferes with the cell's DNA synthesis and decreases the growth and multiplication (cytotoxic effect).
Q 5. What are the side effects of Azishil 100mg injection?
The common side effects of Azishil 100mg injection are nausea, vomiting, diarrhea, constipation, tiredness, decreased appetite, rashes, redness of skin, dizziness, joint pain, headache, sore throat and nose.
Q 6. Is it safe to drive after taking an Azishil 100mg injection?
It is unsafe to drive after taking this injection as it causes dizziness and patients lack concentration and alertness. So, avoid driving and handling heavy machineries after taking this medication.
Fact Box of Azishil 100mg Injection
Molecule name: Azacitidine | Therapeutic class: Anti-metabolites |
Pharmacological class: Anti-Neoplastics | Indications: 1. Treat advanced or metastatic non-small lung cancer (NSCLC), 2. To Treat Advanced or metastatic pancreatic cancer. |
References
- K. Gaston and P.-S. Jayaraman, Transcriptional repression in eukaryotes: Repressors and repression mechanisms, Cellular and Molecular Life Sciences, [May 2003], 60(4):721-741, [Accessed on 5th Apr 2021] https://www.researchgate.net/publication/7094896_Transcriptional_repression_in_eukaryotes_Repressors_and_repression_mechanisms
- Roman M. Shapiro & Alejandro Lazo-Langner, Systematic review of Azacitidine regimens in myelodysplastic syndrome and acute myeloid leukemia, BMC Hematology, 2018 [Accessed on 3rd Apr 2021] https://bmchematol.biomedcentral.com/articles/10.1186/s12878-017-0094-8
- Dr.Reddy’s Laboratories, [Revised on 8th Nov 2018] [Accessed on 5th Apr 2021] https://www.drreddys.com/media/743001/ac-pm-english.pdf
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