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Busefan 60mg Injection
Prescription Required
Salt Composition : Busulfan
Manufacturer : HALSTED PHARMA PVT. LTD.
Origin of Medicine : India
1 Vial(s)
Introduction to Busefan 60mg Injection
Busefan 60mg Injection is an anti-cancer (antineoplastic/cytotoxic) chemotherapy drug which contains an active ingredient as Busulfan. It is an alkyl sulfonate belonging to the class alkylating agent. It is indicated for treating chronic myelogenous leukaemia(( type of cancer that causes an increase in white blood cells)) and given as a conditioning regimen before hematopoietic progenitor cell transplantation(A procedure in which a patient receives healthy blood-forming cells (stem cells) from a donor to replace their own stem cells that have been destroyed by treatment with radiation or high doses of chemotherapy).
Chronic myelogenous leukaemia is an uncommon type of cancer that affects bone marrow (soft,spongy tissue that produces blood cells for your body). It causes an increase in white blood cell count. The term “chronic” indicates that the disease is slowly developed and extended over a long period of time. The word “Myelogenous” describes the type of blood cells that are affected. It typically affects the older rarely occurs in children though any age group can be affected. Busefan 60mg Injections can cause a severe decrease in bone marrow activity. If you are taking any other medications that decrease the blood cell count, talk to your healthcare professional before taking the medications.
Uses of Busefan 60mg Injection
- Hematopoietic progenitor cell transplantation
- Chronic myelogenous leukaemia
- Polycythaemia vera (type of cancer that causes increase in red blood cells)
- Thrombocythemia (increased number of platelets in the blood)
- Myelofibrosis (type of blood cancer where scar tissues are formed in bone marrow)
- Hemoglobinopathies (genetic disorder that produces abnormal haemoglobin)
- congenital metabolic diseases
Therapeutic Effects of Busefan 60mg Injection
Bucelon works by interfering with the DNA replication process, which is necessary for the cells to divide. It stops the tumour growth by inhibiting the cell division.
Interaction of Busefan 60mg Injection with other drugs
Inform your physician regarding any prescribed medicines, over-the-counter medications, nutritional or vitamin supplements, and herbal products that you are taking or have taken before the treatment. Certain medications may interact with Busefan 60mg Injection and can cause potential side effects.
More Information about Busefan 60mg Injection
- It should be stored under refrigerated conditions between 2°C to 8°C (36°F to 46°F).
- Keep it out of sight and reach of children.
How to consume Busefan 60mg Injection
Your physician will decide the formulation, dose, and duration of this therapy. The dose of Busefan 60mg Injection depends on your blood cancer. If you are prescribed the injection, your healthcare professional will administer the injection. Do not self-administer. The injection is administered as an intravenous infusion into the vein. Don't stop the medication until or unless your doctor advises. If you missed the dose, do not take double the doses. Inform your physician about your missed dose.
Safety Advices for Busefan 60mg Injection
Pregnancy
Busefan 60mg Injection comes under pregnancy category D. It may cause foetal harm when administered. If you are pregnant or planning for pregnancy, ask your doctor or pharmacist for advice before taking this medicine. This applies to both men and women because the drug may harm your sperm or eggs.
Breast Feeding
If you are breastfeeding or plan to breastfeed your baby, talk to your physician because the drug may secrete in breast milk.
Lungs
It is unknown whether Busefan 60mg Injection can be given to patients with lung diseases. Please inform your doctor if you have any lung problems.
Liver
Discuss with your physician before taking this medicine if you have liver problems.
Alcohol
It is not known whether it is safe to consume alcohol with Busefan 60mg Injection. Please consult your doctor.
Driving
It is not known whether it is safe to consume alcohol with Busefan 60mg Injection. Please consult your doctor.
Side Effects of Busefan 60mg Injection
Side effects are unwanted symptoms caused by medicines. Even though all medications cause side effects, not everyone gets them. Busefan 60mg Injection causes the following side effects
Severe
- Myelosuppression (decreased bone marrow activity)
Common
- Thalassemia
- Skin rashes
- Hair loss
- Patches of dark skin
- Blood in urine
- Decrease in the number of blood cells and platelets
- Nausea and vomiting
- Jaundice
- Infertility and sterility
- Pneumonia Syndrome
- Itching
Word of Advice
Inform the doctor if the patient has taken radiotherapy priorly to the treatment. If you have any other medical conditions like heart disease, lung, kidney, or liver problems. Tell your doctor if you have any symptoms of gout (pain and swollen joints caused by uric acid crystals). During or after administration of the injection, if you face itchy skin, fever, excessive sweating, rigors or chills, or difficulty in breathing, inform your doctor immediately.
FAQs
Q 1. Can Busefan 60mg Injections cause infertility?
Yes, Busefan 60mg Injections can cause infertility in both the men and women because it affects the sperm cells and egg. Consult the doctor before taking this medication.
Q 2. Can Busefan 60mg Injection be used during pregnancy?
No, it is highly unsafe to use this medication during pregnancy as they can cause harmful effects on the developing foetus.
Q 3. Are there any special precautions patients should be aware of before starting treatment?
Patients should inform the physician about the pregnancy, breastfeeding or if planning for a family. Patients should also inform about the past medical and medication history.
Q 4. What is the package insert that comes with Busefan 60mg Injection?
Package insert contains all the scientific information(indications, uses, side effects, safety and warning, contraindications) about the drug.
Q 5. Does Busefan 60mg Injection cause permanent hair loss?
Yes, Busefan 60mg Injection chemotherapy causes hair loss. Consult the physician about excessive hair loss.
Fact Box of Busefan 60mg Injection
| Molecule Name: Busulfan | Therapeutic class: Anticancer |
| Pharmacological class: Alkylating agent - Alkyl sulfonates | Indication: 1. Chronic myelogenous leukemia 2. Hematopoietic progenitor cell transplantation 3. Polycythaemia vera 4. Thrombocythemia 5. Myelofibrosis 6. Hemoglobinopathies 7. Congenital metabolic diseases |
References
- Aspen, Electronic Medicines Compendium(EMC) (Revised on: July 2020) https://www.medicines.org.uk/emc/product/4653/pil#gref (Accessed: December 14, 2022).
- Busulfan (Revised on: May 19, 2015) National Cancer Institute. https://www.cancer.gov/about-cancer/treatment/drugs/busulfan (Accessed: December 14, 2022).
- Anton Wellstein, Giuseppe Giaccone, Michael B. Atkins, and Edward A. Sausville, Pharmacotherapy of Neoplastic disease: cytotoxic drugs, Goodman & Gilman’s Pharmacological Basis of Therapeutics, 13th Edition, 2018, 1167-1174.
- Buggia I, Locatelli F, Regazzi MB, Zecca M. Busulfan. Ann Pharmacother. 1994 Sep;28(9):1055-62. doi: 10.1177/106002809402800911. PMID: 7803883.
Disclaimer
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