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  ÂCarmendan Injection
Prescription Required
Salt Composition : Levosimendan
Manufacturer : RMPL PHARMA LLP
Origin of Medicine : India
1 Vial(s)
Introduction to Carmendan Injection
The carmendan injection contains an active component of levosimendan and falls into the category of inotropic agents. It is used for the short-term management of acutely decompensated severe chronic heart failure (ADHF), which means when there is a sudden or gradual worsening of the symptoms of heart failure. This medication is used when the standard treatments haven't provided enough relief, and you're still struggling to breathe or need to remove excess fluid from your body.
Do not take this medication if you are under 18 years old or if you have allergies to levosimendan or its components. Also, inform your healthcare provider if you have severe chronic kidney or liver disease or any specific heart condition; it is crucial to avoid this medication in these cases. Before taking this medication, inform your doctor if you are experiencing very low blood pressure (hypotension), have low blood counts (anemia), a significant decrease in blood volume, potassium deficiency, or an abnormally fast heartbeat. Always provide your doctor with a detailed medical history and a list of your current medications before starting this treatment.
Uses of Carmendan Injection
- Short-term management of acute decompensated heart failure (ADHF)
Therapeutic Effects of Carmendan Injection
Carmendan injection exhibits its inotropic and vasodilatory action by sensitizing calcium channels, resulting in increased cardiac output without increasing the oxygen demand of the heart. It also lessens the congestion in your lungs, making it easier for blood and oxygen to go through your body, thereby relieving the shortness of breath due to severe heart failure.
Interaction of Carmendan Injection with other drugs
Inform your doctor about any prescribed medications, over-the-counter medicines, nutritional or vitamin supplements, and herbal products you take or have taken before the treatment. Certain medications may interact with carmendan injection and can cause undesirable side effects. Tell your doctor if you have been given other heart medicines through your veins.
More Information about Carmendan Injection
- Store in refrigerator at (2°C-8°C)
- Do not freeze
- Do not dispose of the medication in wastewater or household waste. Always return to the pharmacy when you no longer require the medication.
How to consume Carmendan Injection
Carmendan injection is given only in a hospital setup by a healthcare provider. It is infused directly into your veins by your physician. Your physician will decide the dosage and frequency of this injection based on the severity of your disease and other factors.Â
Safety Advices for Carmendan Injection
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Pregnancy
 ÂIt is unknown whether carmendan injection is safe during pregnancy. Therefore, it is given when the benefit for the mother outweighs the risk to the fetus. Tell your doctor if you are pregnant, planning to get pregnant, or think you may be pregnant before taking this medication.
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Breast Feeding
 ÂThere are indications that carmendan injection passes into human breast milk. Hence, you should not breastfeed while given this medicine to avoid potential cardiovascular side effects on your baby.
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Lungs
 ÂIt is unknown whether carmendan injection is safe for persons suffering from lung disease. Inform your doctor if you have any lung disease before starting the treatment.
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Liver
 ÂYou should not take carmendan injection if you are affected by severe liver disorder. If you have a mild to moderate liver condition, tell your doctor before getting your carmendan injection.
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Alcohol
 ÂInform your doctor if you have an alcohol addiction because the effect of the alcohol content within this injection may be reduced. It is not recommended to take alcohol during the treatment with carmendan injection. Please consult your doctor for more advice.
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Driving
 ÂIt is unsafe to drive during the treatment because the amount of alcohol in this medicine can affect your ability to use heavy machines or to drive.
Side Effects of Carmendan Injection
Side effects are unwanted symptoms caused by medicines. Even though all medicines cause side effects, not everyone gets them.Â
Common
- Headache
- Abnormally fast heartbeat
- Drop in blood pressure
- A low amount of potassium in your blood
- Insomnia
- Dizziness
- Abnormally fast heartbeats (atrial fibrillation)
- Oxygen insufficiency
- Nausea
- Constipation
- Diarrhea
- Vomiting
- Low blood counts (anemia)
Word of Advice
Carmendan injection is strictly meant for in-hospital use and should be administered by your healthcare provider. Throughout your carmendan Injection treatment, your doctor will closely monitor your heart rate, blood pressure, and electrocardiogram (ECG) to measure how you are responding to the treatment. After you have finished the medication, your doctor will continue monitoring you for about 4-5 days and may adjust your dose when necessary. It is crucial to stick to your regular follow-up appointments to minimize the risk of side effects.
For elderly patients, there are no dose adjustments done, but they require close monitoring. Carmendan injection can cause a drop in potassium levels, so your doctor might prescribe potassium supplements to prevent this. Also, consider incorporating iron-rich foods into your diet, as this medication can lead to anemia. Remember to schedule a complete cholesterol screening (lipid profile test) at least once a year to keep track of your heart health. Additionally, keep an eye on your blood pressure, heart rate, and electrolyte levels. Always consult your doctor if you have any concerns before starting this medication. If you experience any side effects during or after treatment, be sure to inform your healthcare provider promptly.
FAQs
Q 1. Is carmendan injection indicated for children?
No, carmendan injection should not be administered to children and adolescents under 18.
Q 2. How long does the effect of carmendan injection last?
The clinical effect of carmendan injection lasts 7-10 days after the treatment.
Q 3. What precautions should I take before taking carmendan injection?
Your blood pressure and volume should be normal before taking carmendan injection. Inform your doctor thoroughly about your medical history and all the medication you have taken.
Q 4. What are the complications of carmendan injection?
The most common side effects of carmendan injection are headache, dizziness, and low blood pressure.
Q 5. Should I follow any specific diet during the treatment with carmendan injection?
Yes, It is recommended to eat a low-fat diet and iron-rich foods. Include omega-3 fatty acids and fibers in your diet. Avoid smoking and alcohol consumption.
Q 6. Does carmendan injection affect heart rate?
Yes, carmendan injection significantly increases heart rate in a dose-dependent manner.
Fact Box of Carmendan Injection
Molecule Name: Levosimendan | Therapeutic class: Cardiovascular drugs |
Pharmacological class:Â Inotropic agents | Indications: Acute Decompensated Heart Failure (ADHF) |
References
- As Kalceks, Health Products Regulatory Authority (HPRA), [Revised on Feb 2022], [Accessed on 21st Sept 2023], https://www.hpra.ie/img/uploaded/swedocuments/f255c6f4-40a8-4c0f-b034-e20069403900.pdf
- Orion Pharma, Sweden Medical Products Agency (MPA), [Revised on Jun 2010], [Accessed on 21st Sep 2023], https://www.simdax.com/siteassets/simdax-spc.pdf
- KD Tripathi, Essentials of Medical Pharmacology, Cardiovascular drugs, 8th edition, 2019, 568
- Bertram G. Katzung, Drugs Used in Heart Failure, Lange’s Basic and Clinical Pharmacology, 14th Edition, 2018, 212-227.
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