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Cazanat 40mg Tablet
Prescription Required
Salt Composition : Cabozantinib
Manufacturer : NATCO PHARMA LTD
Origin of Medicine : India
30 Tablet(s) In A Bottle
Introduction to Cazanat 40mg Tablet
Cazanat 40mg tablet is an antineoplastic drug with an active ingredient called Cabozantinib. It belongs to the medication class known as tyrosine kinase inhibitors. In adults, it is used to treat advanced kidney cancer and locally advanced or metastatic differentiated thyroid cancer. It is also used in treating liver cancer when Sorafenib (anticancer medicine) is no longer working. Usually, this medicine is given in combination with Nivolumab for advanced kidney cancer. It is not recommended for those younger than 18 years. Â
Do not consume Cazanat 40mg if you are allergic to Cabozantinib and its other ingredients. Inform your physician if you have liver disease, inflammatory bowel disease, high blood pressure, heart disease, or diarrhea. Notify your doctor about the history of blood clots in the leg or significant bleeding, aneurysm (inflammation of blood vessels), or tears in the blood vessel wall. Inform your physician if you are pregnant or planning to get pregnant. Use effective contraception during and even after the treatment or four months. Discuss more fertility concerns with your doctor.Â
Before starting with Cazanat 40mg, notify your doctor if you have a thyroid problem; thyroid functions must be monitored before starting the medicine. Do not forget to inform your physician if you recently had any surgery, including dental surgery, within the last month. Avoid taking grapefruit or grapefruit juice during the treatment as they may increase the level of medicine in the blood. This medicine contains lactose; if you are intolerant to any sugar, inform your doctor before taking the medicine.
Uses of Cazanat 40mg Tablet
- Advanced renal cell carcinoma
- Liver Cancer
- Differentiated thyroid cancer
Therapeutic Effects of Cazanat 40mg Tablet
It acts against a protein called receptor tyrosine kinases and interferes with cell signaling, ultimately stopping the growth and spread of cancer cells. Cazanat 40mg is indicated alone or in combination with Nivolumab.
Interaction of Cazanat 40mg Tablet with other drugs
Inform your doctor about any prescribed medications, over-the-counter medicines, nutritional or vitamin supplements, and herbal products you take or have taken before the treatment. Certain medications such as antibiotics, St, John's Wort, Aliskiren and other medicine may interact with Cazanat 40mg and can cause undesirable side effects.Â
More Information about Cazanat 40mg Tablet
- Keep out of sight and reach of pets and children
- Store protected from light at a temperature not exceeding 30°C.
How to consume Cazanat 40mg Tablet
Take Cazanat 40mg as advised by your physician. Usually, this medicine will be given once a day. Do not crush, chew, or open the medicine. Your physician will decide the correct dosage and duration based on age, body weight, and disease condition. Only stop taking this medicine if your doctor advises you to stop.
Safety Advices for Cazanat 40mg Tablet
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Pregnancy
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Cazanat 40mg is unsafe to use during pregnancy as it may harm the unborn baby. Report to your doctor if you are pregnant or think you may be pregnant or planning for the pregnancy before starting the treatment.Â
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Breast Feeding
 ÂTaking Cazanat 40mg while breastfeeding may be unsafe because it may affect the child. Do not breastfeed for at least four months after the treatment. Therefore, talk with your doctor to get more information.Â
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Lungs
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It is unknown whether Cazanat 40mg is safe to administer in patients with lung problems. Inform your physician if you have any lung disease before starting the treatment. Contact your doctor if you experience any lung-related symptoms.
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Liver
  Inform your physician if you have liver problems because Cazanat 40mg should be used cautiously with this condition.
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Alcohol
 ÂIt is unknown whether consuming alcohol while taking a Cazanat 40mg tablet is safe. Please speak with your physician.
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Driving
  While taking Cazanat 40mg, it is unsafe to drive or use machines because it may cause nausea, changes in vision, vomiting, etc. Talk to your doctor for more information.Â
Side Effects of Cazanat 40mg Tablet
Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them.
Serious
- Gastrointestinal perforation
- Severe or uncontrollable bleeding
- Shortness of breath
- Nonhealing wound
- Pain in the mouth, jaw/teeth, hand, feet,
- Loss of consciousness,
- Drowsy
- Swelling or sores in the mouth
- Blood vomiting
- Black stools
- Blood in urine
- Headache
- Coughing blood
Common
- Dehydration
- Difficulty swallowing
- Ringing in the ears
- Blood clots in the veins
- Fluctuation in the blood sugar levels
- The lower level of albumin
- Electrolyte imbalance
- Increased levels of liver enzymes
- Elevated cholesterol levels in the blood
- Hair loss
- Changes in hair color
- Muscle spasm
- Skin thickening
- Dry skin
- Itching
- Protein in urine
Word of Advice
Oral contraception may be ineffective while under the treatment of Cazanat 40mg. Discuss effective contraception methods with your doctor, along with fertility concerns. Inform your doctor if you have a thyroid problem; thyroid function should be monitored regularly before taking this medicine. Notify your doctor if your face gets colder or tired more commonly or if your voice deepens while taking this medicine. Do not stop the medicine until your doctor advises. Notify your doctor if you experience any serious side effects. You are doctor may change your dose or stop the treatment. Your doctor will inform you if you need any dose adjustments. This medicine is not recommended for children or adolescents.
FAQs
Q 1. Can Cazanat 40mg cause a lower level of albumin?
One of the common side effects of Cazanat 40mg is the lower level of albumin. If you experience any side, contact your physician immediately.
Q 2. Why is it recommended to use effective contraception during the treatment of Cazanat 40mg?
To avoid unwanted pregnancy, it is advised to use effective contraception. Oral contraception may be ineffective, so it is better to discuss effective contraception with your doctor.
Q 3. Why is liver enzyme getting elevated during treatment with Cazanat 40mg?
The reason for this elevation is not completely understood, but it is thought to be related to the drug's effects on certain enzymes involved in liver function. The elevation in liver enzymes is generally mild and temporary and typically resolves on its own or with dose adjustment of the Cazanat 40mg tablet.
Q 4. How can I manage diarrhea while taking Cazanat 40mg?
If you experience diarrhea while taking Cazanat 40mg, staying hydrated by drinking plenty of fluids is important. Your doctor may also recommend over-the-counter or prescription medications to help manage your diarrhea. If your diarrhea is severe or persistent, you should contact your doctor.
Q 5. Is Cazanat 40mg a chemotherapy drug?
Yes, Cazanat 40mg is a chemotherapy medication that belongs to the group of Tyrosine kinase inhibitors.
Fact Box of Cazanat 40mg Tablet
| Molecule Name: Cabozantinib | Therapeutic class: Antineoplastics |
| Pharmacological class: Tyrosine kinase inhibitor | Indications:Â 1. Advanced renal cell carcinoma 2. Liver Cancer 3. Differentiated thyroid cancer |
References
- Ipsen Pharma, Electronic Medicines Compendium (EMC), [Revised on July 2022] [Accessed on 25th April 2023], Cabometyx 20 mg Film-coated Tablets - Summary of Product Characteristics (SmPC) - (emc) (medicines.org.uk)
- Exelixis, Inc., [Revised on Oct 2020] [Accessed on 25th April 2023], https://www.cometriq.com/downloads/Cometriq_Full_Prescribing_Information.pdf
- Gregory A. Brent and Ronald J. Koenig, Thyroid and Antithyroid Drugs, Goodman & Gilman’s Pharmacological Basis of Therapeutics, 2018, 787-801.
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