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Celdaz 500mg Injection
Prescription Required
Salt Composition : Dacarbazine
Manufacturer : CELON LABORATORIES LTD
Origin of Medicine : India
1 Vial(s)
Introduction to Celdaz 500mg Injection
Celdaz 500mg injection is an antineoplastic drug belonging to the class of alkylating agents, containing the active ingredient Dacarbazine. It is used to prevent and treat metastatic malignant melanoma (skin cancer), Hodgkin's disease (cancer that forms in the lymph system, part of the immune system).
It is often combined with cisplatin, a cytotoxic agent, to treat certain types of cancers for the treatment of Hodgkin's lymphoma, and also combined with temozolomide for the treatment of melanoma. There may be an increased risk of certain types of skin cancer (non-melanoma skin cancer) with the use of this medicine. This drug is contraindicated in pregnant women, and women of childbearing potential should use effective contraception during and for at least 6 months after treatment with the drug. It is not known whether it is excreted in human milk, so breastfeeding should be avoided during treatment with the drug. It should also be used with caution in patients with pre-existing liver or kidney dysfunction. You should not have a live vaccine if you are having this injection. This is because it may weaken your immune system and make you more likely to catch a serious infection. Consult your doctor immediately for more advice.
Celdaz 500mg injection may cause pain along the vein. If you feel pain, tell your nurse straight away so that the infusion site can be checked. They may give the drug more slowly or flush it through with more fluids to reduce pain. Treatment should not be started if your white blood cells (leukocytes) have fallen to counts below determined levels. Your doctor will determine these values at regular intervals. This medicine should not be used if you are allergic to this drug. Before each administration, you will have blood tests to check that you have enough blood cells to receive this medicine. It is usually administered once every three to four weeks. Tell your physician about all the medications you have been taking recently, including herbal medicines and supplements, before taking this injection.
Uses of Celdaz 500mg Injection
- Metastatic malignant melanoma
- Hodgkin’s disease
Therapeutic Effects of Celdaz 500mg Injection
It is a type of alkylating agent, which works majorly through the process of alkylation. It enters the cancer cells after getting activated by the liver and inhibits DNA synthesis. This process disrupts the normal cell cycle and DNA function, leading to arrest in cancer cell growth and multiplication.
Interaction of Celdaz 500mg Injection with other drugs
Inform your healthcare provider about all the medicines you take, including prescription medications, over-the-counter medications, nutritional or vitamin supplements, and herbal products. Certain medications may interact with Celdaz 500mg injection and reduce effectiveness by causing undesirable side effects.
More Information about Celdaz 500mg Injection
- Store Celdaz 500mg injection in the refrigerator (2°-8°C). Do not freeze.
- Keep it out of reach from children and pets.
How to consume Celdaz 500mg Injection
The medicine will be administered to you by a healthcare professional in a hospital setting. Celdaz 500mg injection will be given intravenously into a vein in your arm or hand. Do not self-administer this medicine. The specific dose and schedule of administration depend on the type and stage of the cancer being treated. This injection is usually given about 30 minutes before you receive your anti-cancer medicine (chemotherapy). During the infusion, you will be monitored for any side effects or reactions to the medication. It is important to get the dose at the scheduled time. If you missed the schedule, contact your doctor and reschedule the dose.
Safety Advices for Celdaz 500mg Injection
Pregnancy
Celdaz 500mg injection is not recommended for pregnant women as it may cause fetal harm. Consult your doctor if you are pregnant or planning for pregnancy during the treatment.
Breast Feeding
It is not known if Celdaz 500mg injection passes into your breast milk or if it will affect your baby. Please consult your doctor before breastfeeding.
Lungs
It is not known whether Celdaz 500mg injection can be administered to patients with lung problems. Consult your doctor if you have any lung diseases before starting the treatment.
Liver
Inform your doctor if you have any liver problems before taking Celdaz 500mg injection. Regular monitoring of liver function tests is recommended.
Alcohol
Consuming alcohol may affect the effectiveness of Celdaz 500mg injection. Stop consuming alcohol if you are taking this medicine.
Driving
It is unsafe to drive vehicles or operate heavy machinery after taking Celdaz 500mg injection, it may cause dizziness and impair your concentration.
Side Effects of Celdaz 500mg Injection
Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them.
Serious
- Sore throat or high temperature indicating infection
- Unusual bleeding or bruising
- Severe vomiting or diarrhea
- Extreme tiredness
- Severe allergic reaction, characterized by swelling of hands, feet, ankles, face, lips, mouth or throat; rashes or giddiness.
- Headache, vision problems, fits, confusion, lethargy or numbness of face
- Severe liver problems
Common
- Low levels of RBC, WBC and platelets in blood.
- Loss of appetite
- Nausea, vomiting
- Hair loss
- Skin reactions
Word of Advice
Celdaz 500mg injection can cause harm to a developing fetus or nursing baby, so it is important to discuss contraception options and the need to avoid breastfeeding during treatment. This drug causes fatigue, so encourage the patient to take enough rest and self-care during treatment. It increases the risk of bleeding and bruising, so it is important to be careful when using sharp objects or participating in activities that may result in injury.
FAQs
Q 1. Is Celdaz 500mg injection prescribed as a monotherapy?
Celdaz 500mg injection is often used as a monotherapy to treat melanoma, which is a type of skin cancer. It may also be used as a monotherapy to treat Hodgkin's lymphoma in patients who cannot tolerate other chemotherapy drugs.
Q 2. How will I receive Celdaz 500mg injection?
Celdaz 500mg injection is administered into a vein as a short-term infusion over 30 – 60 minutes.
Q 3. Can Celdaz 500mg injection be used in combination with other drugs?
Yes, Celdaz 500mg injection is often used in combination with other chemotherapy drugs to improve treatment outcomes.
Q 4. Whether Celdaz 500mg injection is safe to use during pregnancy?
Celdaz 500mg injection is not recommended during pregnancy and it is unsafe because it may harm a developing fetus. Women who are pregnant or planning to become pregnant should discuss their treatment options with their doctor immediately.
Q 5. Who should not take Celdaz 500mg injection?
Celdaz 500mg injection is not recommended for people who are allergic to this drug and any of its ingredients. It should also be avoided in patients who have severe bone marrow suppression or blood cell disorders, as well as those with severe liver or kidney disease.
Q 6. Can I drink alcohol while receiving treatment with Celdaz 500mg injection?
It is not recommended to drink alcohol while receiving treatment with Celdaz 500mg injection, as it may increase the risk of side effects and interfere with the effectiveness of the drug.
Q 7. Is Celdaz 500mg injection light sensitive?
It is recommended to protect Celdaz 500mg injection from light during storage and administration to ensure the drug's stability and effectiveness.
Fact Box of Celdaz 500mg Injection
Molecule name: Dacarbazine | Therapeutic class: Anti-cancer |
Pharmacological class: Alkylating agents | Indications: 1. Metastatic malignant melanoma 2. Hodgkin’s disease |
References
- Medac, [Revised on Jul 2020] [Accessed on 27th March 2023] https://www.hpra.ie/img/uploaded/swedocuments/1d9264f6-b924-4af9-9b27-af9c9593d4a3.pdf
- Hospira, Inc., [Revised on Apr 2021] [Accessed on 27th March 2023], http://labeling.pfizer.com/ShowLabeling.aspx?id=5938
- Devendra Choudhary, Hanmant Goykar, Dnyaneshwar Kalyane, Nagaraja Sreeharsha, Rakesh K.Tekade, Prodrug design for improving the biopharmaceutical properties of therapeutic drugs, The Future of Pharmaceutical Product Development and Research, 1st Edition, 2020, 179-226.
- Goodman & Gilman’s, The Pharmacological Basis of Therapeutics, Chemotherapy of neoplastic diseases, 12th edition, 2011, 1686 and 1687.
- Bertram.G.Katzung, Basic and Clinical Pharmacology, Cancer Chemotherapeutic drugs, 14th edition, 2017, 956.
- KD Tripathi, Essentials of Medical Pharmacology, Anticancer drugs, 7th edition, 2013, 861.
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