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Clexane 40mg Injection
Prescription Required
Salt Composition : Enoxaparin
Manufacturer : SANOFI INDIA LTD
Origin of Medicine : France
1 Prefilled Syringe(s) Of 0.4ml
Introduction to Clexane 40mg Injection
Clexane 40mg Injection is an anticoagulant drug belonging to the category of low molecular weight heparin (LMWH). It contains the active ingredient Enoxaparin. It is used to treat severe blood clots. This drug also prevents the occurrence of deep vein thrombosis in abdominal surgery, hip replacement surgery, knee replacement surgery, and in people with severe movement restrictions. This injection prevents further heart complications in patients with unstable angina and non-Q wave myocardial infarction.
Clexane 40mg Injection is not recommended for patients with active bleeding, hypersensitivity, or allergies to the active compound, as well as those with a history of heparin-induced thrombocytopenia before taking Clexane 40mg Injection, tell your physician if you are allergic to Enoxaparin, heparin, benzyl alcohol, or pork products.Â
Your healthcare provider will regularly monitor you for signs of bleeding. Inform your healthcare practitioner if you are diagnosed with kidney problems. It is not recommended for use in children and adolescents below 18 years.Â
Clexane 40mg Injection is not recommended if you undergo procedures like neuraxial anaesthesia or spinal puncture. It is recommended to monitor older adults and patients with low weight for increased risk of bleeding.
Tell your physician if you suspect pregnancy, breastfeeding, or planning to have a baby. Clexane 40mg Injection may increase the chance of bleeding in pregnant women with artificial heart valves, and hence, close monitoring must be done.Â
Consult your doctor for more advice before starting Clexane 40mg Injection medication, it is recommended not to take any hemostatic drugs unless absolutely necessary. It is needed to inform your physician about all the drugs you are taking, including herbal and vitamin supplements.
Uses of Clexane 40mg Injection
Clexane 40mg Injection is used in the treatment of the following:
- Deep vein thrombosis
- Prophylaxis of venous thrombo-embolism
- Unstable angina
- ST-segment Elevation Myocardial Infarction (STEMI)
- Prevention of blood clots during surgeries
Therapeutic Effects of Clexane 40mg Injection
Clexane 40mg Injection binds to the antithrombin to form a complex. Antithrombin is a protein that blocks the formation of abnormal blood clots. This drug mainly prevents the activation of factor Xa, eventually preventing clot formation. It is commonly used for the prevention and treatment of conditions associated with increased risk of blood clots.
Interaction of Clexane 40mg Injection with other drugs
Some medicinal products that affect haemostasis should be discontinued before starting Clexane 40mg Injection therapy unless absolutely necessary. If a combination is required, Clexane 40mg Injection should be used with careful clinical and laboratory monitoring.Â
These products include systemic salicylates, acetylsalicylic acid at anti-inflammatory doses, NSAIDs like ketorolac, other thrombolytics such as alteplase, reteplase, streptokinase, tenecteplase, urokinase, and other anticoagulants.Â
Always inform your doctor about any medicines or supplements you are taking, as they may interact with Clexane 40mg Injection.
More Information about Clexane 40mg Injection
- Store Clexane 40mg Injection below 25 °C.
- Do not freeze
- Keep it out of reach from children.
- Protect them from light and moisture.
How to consume Clexane 40mg Injection
Clexane 40mg Injection will be administered to you by a healthcare professional in a hospital setting. It is usually administered as an intravenous injection into a vein. Your doctor will decide the dose, route of administration, and frequency based on your disease condition and other factors.
Safety Advices for Clexane 40mg Injection
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Pregnancy
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Before beginning therapy with Clexane 40mg Injection, tell your doctor if you are pregnant, suspect you are pregnant, or are planning to become pregnant. It is not known that Clexane 40mg Injection interferes with pregnancy.
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Breast Feeding
 ÂIt is unknown if Clexane 40mg Injection is excreted unaltered in breast milk. Please consult your doctor before breastfeeding.Â
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Lungs
  It is unknown whether Clexane 40mg Injection is safe for patients with lung problems. Consult your doctor if you have lung disease before starting the treatment.
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Liver
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Inform your doctor if you have liver disease because of Clexane 40mg Injection should be used cautiously with a liver condition.
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Alcohol
 ÂIt is unknown whether consuming alcohol while taking an Clexane 40mg Injection is safe. Please speak with your physician.
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Driving
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It is safe to travel, drive vehicles, or operate heavy machinery after administering Clexane 40mg Injection. The medicine does not impair any alertness and coordination.
Side Effects of Clexane 40mg Injection
Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them.
Serious side effects of Clexane 40mg Injection are:
- Severe allergic reactions (swelling of lips, tongue, or throat, difficulty breathing, or swallowing)
- Too much bleeding (weakness, being pale, dizziness with headache, or unexplained swelling)
- Blockage of blood vessels (pain, redness, or swelling in the legs, or coughing up blood)
- Rash of dark red spots under the skin
Common side effects of Clexane 40mg Injection are:
- Bleeding
- Bruising more easily
- Low blood cell counts
- Headache
- Itchy red skin
- Edema
- Pain at the injection site
- Pink patches on the skin
Word of Advice
Clexane 40mg Injection can cause bleeding and many undesirable side effects; hence it is advised to get adequate rest during the treatment. Eat a well-balanced diet. Apply a cool compress at the injection site to reduce pain and irritation. Clexane 40mg Injection should not be stopped suddenly without first talking to your doctor because doing so may raise your risk of blood clots.Â
Aspirin and other non-steroidal anti-inflammatory medicines (NSAIDs) may increase the risk of bleeding when combined with Clexane 40mg Injection, so it is not recommended to take them without first talking to your doctor. Keep away from activities that put you at higher risk of bleeding or getting hurt, like contact sports and activities.Â
Foods high in Vitamin K may have an impact on blood clotting and may interfere with the way anticoagulant drugs like Clexane 40mg Injection. It is recommended to eat leafy green vegetables, asparagus, Brussels sprouts and soybean oil in moderation. It is advised to monitor your platelet count regularly.
FAQs
Q 1. Who should not take Clexane 40mg Injection?
Clexane 40mg Injection is not recommended for people suffering from active major bleeding or a history of hypersensitivity to this drug, heparin, Benzyl alcohol, or pork products. This drug is also not advised for people with a history of heparin-induced thrombocytopenia in the past hundred days.
Q 2. What should you not take with Clexane 40mg Injection?
When taking Clexane 40mg Injection, it's important to avoid certain medications, supplements, and activities that may increase the risk of bleeding or interact with the anticoagulant effects of Clexane 40mg Injection including other anticoagulants, non-steroidal anti-inflammatory drugs, and anti-platelets.
Q 3. What are the common side effects of Clexane 40mg Injection?
Common side effects of Clexane 40mg Injection may include bleeding or bruising at the injection site, nosebleeds, nausea, headache, and itching. Serious side effects such as severe bleeding or allergic reactions are rare but may occur.
Q 4. How long should Clexane 40mg Injection treatment continue?
The duration of Clexane 40mg Injection treatment depends on the underlying condition being treated, the risk of clotting, and individual patient factors. Treatment may be short-term (e.g., during hospitalisation or surgical procedures) or long-term for chronic conditions such as DVT or PE.
Q 5. When should you report to the doctor while using Clexane 40mg Injection?
Contact your physician directly if you experience severe allergic reactions like the spelling of lips, tongue, throat, difficulty breathing or swallowing, unexplained swelling, painful Rash, chest pain, or blood in the cough during the treatment with Clexane 40mg Injection.
Q 6. How should Clexane 40mg Injection be stored?
Clexane 40mg Injection should be stored at room temperature (between 68°F to 77°F or 20°C to 25°C) away from light and moisture. It should be kept out of the reach of children and not be frozen. Unused portions of Clexane 40mg Injection solution should be discarded according to the manufacturer's instructions.
Fact Box of Clexane 40mg Injection
Molecule Name: Enoxaparin | Therapeutic class: Anticoagulant |
Pharmacological class: Low molecular weight heparin (LMWH) | Indications: Treat and prevent blood clot |
References
1. Rovi Pharma Industrial ServicesElectronic Medicines Compendium (EMC), [Revised on Apr 2022], [Accessed on March 2024],https://www.medicines.org.uk/emc/files/pil.9331.pdfÂ
2. Sanofi, [Revised on Apr 2022] [Accessed on March 2024], https://products.sanofi.us/lovenox/lovenox.pdf
3. Sanofi India Limited, Central Drugs Standard Control Organisation (CDSCO), [Revised on Dec 2018], [Accessed on March 2024], https://cdsco.gov.in/opencms/resources/UploadCDSCOWeb/2018/UploadPrescribingInfo/1CLEXANE-SANOFI.pdfÂ
4. KD Tripathi, Essentials of Medical Pharmacology, Drugs Affecting Coagulation, Bleeding and Thrombosis, 8th Edition, 2019, 659-681.
5.https://www.ema.europa.eu/en/documents/product-information/inhixa-epar-product-information_en.pdf
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