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Combinib 250mg Tablet
Prescription Required
Salt Composition : Lapatinib
Manufacturer : CIPLA LTD
Origin of Medicine : India
30 Tablet(s) In A Bottle
Introduction to Combinib 250mg Tablet
Combinib 250mg Tablet contains the active ingredient lapatinib. It is indicated to treat advanced breast cancer and it may be used alone or in combination with other medications. It is effective against cells sensitive to hormones and rapidly multiplying cancer cells that produce most of the protein called human epidermal growth receptor -2.
The common side effects that are likely to occur while you are on the treatment with Combinib 250mg Tablet are nausea, vomiting, tiredness, weakness, itching, dry skin, loss of appetite, indigestion, constipation, mouth ulcers, stomach pain, difficulty in sleeping, joint or back pain, cough, breathing problems, headache, etc. If you experience severe allergic reactions, skin rashes, heart, liver, and lung problems, report your physician immediately.
Inform your healthcare provider at the first sign of diarrhea or dehydration. Monitor your blood pressure regularly while taking Combinib 250mg Tablet. If you have diarrhea while taking this medication, drink plenty of fluids, eat low-fat, high-protein foods, and avoid milk and its products and herbal supplements.
Uses of Combinib 250mg Tablet
- Treats advanced or HER2 Positive metastatic breast cancer.
Therapeutic Effects of Combinib 250mg Tablet
Combinib 250mg Tablet acts against the enzyme called tyrosine kinase. It prevents the Human epidermal growth factor receptor protein (HER2) and Epidermal growth factor receptors (EGFRs) from signaling, which are produced by breast cancer cells. It kills cancer cells and slows down their growth.Â
Interaction of Combinib 250mg Tablet with other drugs
Inform your doctor about any prescribed medications, over-the-counter medicines, nutritional and vitamin supplements, and herbal products you take or have taken before the treatment. Certain medications may interact with Combinib 250mg Tablet Injection and cause undesirable side effects.
More Information about Combinib 250mg Tablet
- Store below 30°C and away from light.
How to consume Combinib 250mg Tablet
Take Combinib 250mg Tablet exactly as prescribed by your doctor. Take this medicine at least 1 hour before or after taking the food. Swallow the tablet and do not crush, open, or dissolve them.Â
Safety Advices for Combinib 250mg Tablet
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Pregnancy
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It is not safe to consume Combinib 250mg Tablet while you are pregnant. Consult your doctor and use a reliable contraception method to avoid becoming pregnant during this treatment.
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Breast Feeding
 ÂCombinib 250mg Tablet is unsafe during breastfeeding as this medication tends to pass into the breast milk and affect the baby.
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Lungs
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Talk to your doctor if you have any lung conditions before starting treatment with Combinib 250mg Tablet.
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Liver
  Combinib 250mg Tablet should be used with caution in patients with severe liver disease. Consult your physician for advice.
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Alcohol
 ÂAvoid drinking alcohol while taking Combinib 250mg Tablet as it may cause dizziness.
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Driving
  Combinib 250mg Tablet may affect your ability to drive or perform activities that require focus. Exercise caution while driving or using machines.
Side Effects of Combinib 250mg Tablet
Side effects are unwanted symptoms caused by medicines. Even though all medications cause side effects, not everyone gets them.
Serious
- Diarrhea
- Severe allergic reactions
- Skin rash
- Heart problems
Common
- Loss of appetite
- Nausea, vomiting
- Tiredness, weakness
- Indigestion
- Constipation
- Sore mouth or mouth ulcers
- Stomach pain
- Trouble sleeping
- Back pain
- Pain in the hands and feet
- Joint or back pain
- Cough, breathlessness
- Headache
- Nose bleed
- Hot flush
- Unusual hair loss
- Dry skin and itching
Word of Advice
Combinib 250mg Tablet can cause severe diarrhea, so it is advised to take plenty of water during the treatment. Eat a well-balanced diet. Avoid consuming grapefruit juice while on treatment with Combinib 250mg Tablet as it affects how the medicine works. This medication makes your skin sensitive to the sun and increases the risk of skin rashes. Avoid spending more time in the sunlight, and ensure that you always apply sunscreen with a good SPF before stepping out. Wash your skin with a soap-free cleanser.
FAQs
Q 1. What is Combinib 250mg Tablet used for?
Combinib 250mg Tablet is used to treat advanced or HER2 Positive metastatic breast cancer.
Q 2. What is the most common side effect of Combinib 250mg Tablet?
The most common side effect of Combinib 250mg Tablet is Diarrhea. To prevent dehydration, consume lots of liquids, such as water or juice. If it is serious, consult your doctor right away.
Q 3. How does Combinib 250mg Tablet work?
Combinib 250mg Tablet acts against the enzyme called tyrosine kinase. It prevents the Human epidermal growth factor receptor protein (HER2) and epidermal growth factor receptors (EGFRs) from signaling, which breast cancer cells produce. It kills cancer cells and slows down their growth.
Q 4. Is it safe to take Combinib 250mg Tablet while drinking juice?
No. Drinking grapefruit juice while taking Combinib 250mg Tablet can cause harmful interaction. Take this medicine with water only.
Q 5. Can a pregnant woman take Combinib 250mg Tablet?
No, Combinib 250mg Tablet is unsafe during pregnancy as it may harm the unborn baby. Therefore, it is advisable to tell your healthcare provider if you are pregnant or planning to have a baby before taking this medicine.
Q 6. Is Combinib 250mg Tablet safe for breastfeeding women?
Combinib 250mg Tablet is unsafe during breastfeeding as this medication passes into the breastmilk and affects the baby. It is not to be taken without the doctor's consent.
Fact Box of Combinib 250mg Tablet
Molecule name: Lapatinib | Therapeutic class: Antineoplastic agent |
Pharmacological class: Kinase inhibitor | Indications: Treats advanced or HER2 Positive metastatic breast cancer. |
References
1. Edward Chu, Cancer Chemotherapy, Lange’s Basic and Clinical Pharmacology, 14th Edition, 2018, 948-976.Â
2. KD Tripathi, Anticancer Drugs, Essentials of Medical Pharmacology, 8th Edition, 2019, 915-936.
3. Novartis Europharm Limited, Electronic medicines compendium (emc), [ Revised on March 2022] [ Accessed on 19th August 2022], https://www.medicines.org.uk/emc/files/pil.6292.pdf
4. GlaxoSmithKline, US Food & Drug Administration, [ Accessed on 19th August 2022], https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/022059s007lbl.pdf
Disclaimer
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