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Comtripsy 15mg Tablet
Prescription Required
Salt Composition : Trifluridine And Tipiracil
Manufacturer : INTAS PHARMACEUTICALS LTD
Origin of Medicine : India
10 Tablet(s) In A Strip
Introduction to Comtripsy 15mg Tablet
Comtripsy 15mg Tablet is an anticancer medication containing the two active constituents Trifluridine and Tipiracil. It is used to treat adults with colon and rectum cancer when it reaches the metastases stage (cancer has spread to other parts of the body) and when other treatments are unsuitable. Trifluridine inhibits the growth of cancer cells, whereas Tipiracil stops the Trifluridine from being broken down and helps it to work longer. Cancer is a condition in which the cells multiply uncontrollably and abnormally. This medicine is not recommended for adolescents and children under 18.
Do not consume this medicine if you are allergic to Trifluridine and Tipiracil or its other ingredients. Before starting the treatment, notify your doctor if you have a problem with your kidney or liver and are lactose intolerant. This treatment may lead to side effects such as neutropenia (lowered WBC), anemia (reduced number of RBC), and gastrointestinal problems. Report your doctor if you experience any side effects or symptoms. Dose adjustment is needed in patients with a kidney condition. Inform your doctor if you are preganat or planning to get pregnant; this medicine may harm the unborn baby, so use contraception by both males and females during and after the treatment for six months.
Uses of Comtripsy 15mg Tablet
- Metastatic colorectal cancer
Therapeutic Effects of Comtripsy 15mg Tablet
Trifluridine interferes with the DNA synthesis of cancer cells and inhibits the growth of cancer cells. Tipiracil stops the body from breaking down Trifluridine and increases its exposure.
Interaction of Comtripsy 15mg Tablet with other drugs
Inform your doctor about any prescribed medications, over-the-counter medicines, nutritional or vitamin supplements, and herbal products you take or have taken before the treatment. Certain medications, such as Zidovudine and others, may interact with Comtripsy 15mg Tablet and cause undesirable side effects.
More Information about Comtripsy 15mg Tablet
- Keep Comtripsy 15mg Tablet out of sight and reach of children.
- Store at room temperature (20°C - 25°C).
How to consume Comtripsy 15mg Tablet
Take Comtripsy 15mg Tablet as advised by your physician. Usually, this medicine will be taken as a whole with a glass of water. Do not crush, chew, or open the medicine. Your physician will decide the correct dosage and duration based on age, body weight, and disease condition. Only stop taking this medicine if your doctor advises you to stop.
Safety Advices for Comtripsy 15mg Tablet
Pregnancy
Comtripsy 15mg Tablet are unsafe during pregnancy as they may harm the unborn baby. Report to your doctor if you are pregnant or think you may be pregnant or planning for the pregnancy before starting the treatment. Use effective contraception.
Breast Feeding
Taking Comtripsy 15mg Tablet while breastfeeding may be unsafe because it may affect the child. Do not breastfeed for at least four months after the treatment. Therefore, talk with your doctor to get more information.
Lungs
It is unknown whether Comtripsy 15mg Tablet are safe for patients with lung problems. Inform your physician if you have any lung disease before starting the treatment. Contact your doctor if you experience any lung-related symptoms.
Liver
Inform your physician if you have liver problems because Comtripsy 15mg Tablet should be used cautiously with this condition.
Alcohol
It is unknown whether consuming alcohol while taking a Comtripsy 15mg Tablet is safe. Please speak with your physician.
Driving
While taking Comtripsy 15mg Tablet, driving or using machines is unsafe because it may affect your ability to concentrate and react. Talk to your doctor for more information.
Side Effects of Comtripsy 15mg Tablet
Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them.
Serious
- Low white blood cell count (fever, chills)
- Anemia (shortness of breath, tiredness)
- Diarrhea, vomiting, abdominal pain
- Unusual bleeding or bruising
- Severe gastrointestinal problem
Common
- Lack of appetite
- Nausea
- Hair loss
- Weight loss
- Changes in taste
- Constipation
- Swelling in hands or feet or mucous membranes
- Mouth pain
- Itchy dry skin
- A lower level of albumin
- Increased bilirubin
- Increase liver enzymes
Word of Advice
Notify your doctor if you are intolerant to sugar, as this medicine contains lactose. Your doctor may adjust the dosage if you are an inpatient with a kidney condition. Comtripsy 15mg Tablet come in two strengths, usually given twice a day. Your doctor may take a blood test before each test. Discuss the effective contraception method with your doctor.
FAQs
Q 1. Who should not take Comtripsy 15mg Tablet?
Comtripsy 15mg Tablet should not be taken by individuals who are allergic to any of its components. It should also be avoided by individuals with severely decreased bone marrow function (reduction in blood count), severe infections, or severe renal or hepatic impairment.
Q 2. Can Comtripsy 15mg Tablet be taken with other medications?
Comtripsy 15mg Tablet may interact with other medications, so it is important to inform your doctor of all the medications, vitamins, and supplements you are currently taking.
Q 3. Can Comtripsy 15mg Tablet affect our immune system?
Comtripsy 15mg Tablet are not known to affect the immune system directly, but they can indirectly affect it by reducing the number of white blood cells (WBC) in the body. This can increase the risk of infections.
Q 4. What should I do if I miss a dose of Comtripsy 15mg Tablet?
If you miss a dose of Comtripsy 15mg Tablet, take it as soon as you remember. Don't double dose to make up for a missed one.
Q 5. At what condition is dose adjustment needed for Comtripsy 15mg Tablet?
If you are a patient with kidney disease, inform your doctor before starting the treatment because adjustment is needed in kidney-conditioned patients.
Fact Box of Comtripsy 15mg Tablet
Molecule Name: Trifluridine and Tipiracil | Therapeutic class: Antimetabolites |
Pharmacological class: Thymidylate Synthetase Inhibitors | Indications: Metastatic colorectal cancer |
References
1. Les Laboratories Servier, Electronic medicines compendium (EMC), [Revised on Dec 2020] [Accessed on 25th April 2023], https://www.medicines.org.uk/emc/files/pil.7309.pdf
2.Taiho Oncology, US Food, and Drug Administration, [Revised on Feb 2019] [ Accessed on 25th April 2023], https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/207981s008lbl.pdf
3.Celeste B Burness, Sean T Duggan; Trifluridine/Tipiracil: A Review in Metastatic Colorectal Cancer; Drugs; Published on Sep 2016; Accessed on 03/03/2022; https://pubmed.ncbi.nlm.nih.gov/27568360/
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