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Dapefy S 10mg/50mg Tablet

Prescription Required

Salt Composition : Dapagliflozin,sitagliptin

Manufacturer : SUN PHARMACEUTICAL INDUSTRIES LTD

Origin of Medicine : India

MRP: ₹279
Price : ₹237
You Save : ₹42 (15%)

15 Tablet(s) In A Strip

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Get financial assistance directly from pharma companies and cover your cost of medicines, or get free medicines for eligible patients with patient assistance programs (PAP). We provide proper guidance to patients enrolled in the patient assistance program.

Introduction to Dapefy S 10mg/50mg Tablet

Dapefy S 10mg/50mg tablets contains an active component as Dapagliflozin and sitagliptin. These are two different medications used to treat type 2 diabetes mellitus. They work through different mechanisms and can be combined to help control blood sugar levels in certain patients. Dapagliflozin is a medication belonging to the class of drugs called sodium-glucose cotransporter 2 (SGLT2) inhibitors. This helps to lower blood glucose levels and reduce the overall blood sugar burden in the body. Sitagliptin is a medication is classified as a dipeptidyl peptidase-4 (DPP-4) inhibitor. It regulates the blood glucose levels by stimulating insulin release and reducing glucagon production, a hormone that raises blood sugar. This medication can be particularly beneficial for overweight or obese individuals with type 2 diabetes, as it can help achieve and maintain healthy body weight. It is indicated for treating type 2 diabetes only and should not be used to treat type 1 diabetes.

Individuals with known hypersensitivity or allergy to Dapefy S 10mg/50mg tablets or other components of these medications should not take them. It is primarily eliminated through the kidneys. Therefore, individuals with severe renal impairment or end-stage renal disease should not use this medication. During periods of illness, surgery, or other stressful situations, there may be an increased risk of developing ketoacidosis, particularly in those taking dapagliflozin. Temporary discontinuation of this medication during such events may be necessary. There is limited data on the safety of Dapefy S 10mg/50mg tablets during pregnancy and breastfeeding. Pregnant or breastfeeding individuals should consult their healthcare provider before using this medication.

Uses of Dapefy S 10mg/50mg Tablet

Dapefy S 10mg/50mg tablets is used to treat the following:

  • Type 2 diabetes mellitus
  • Obese individuals with type 2 diabetes

Therapeutic Effects of Dapefy S 10mg/50mg Tablet

The Dapefy S 10mg/50mg tablets in the treatment of type 2 diabetes provides a dual therapeutic effect by lowering blood glucose levels through different mechanisms: dapagliflozin reduces glucose reabsorption in the kidneys, leading to increased urinary excretion, while sitagliptin enhances insulin secretion and reduces glucagon production. This approach improves glycemic control, reduces the risk of hypoglycemia, and may offer cardiovascular and renal benefits.

Interaction of Dapefy S 10mg/50mg Tablet with other drugs

Inform the doctor about your medicines, including prescription, over-the-counter, nutritional or vitamin supplements, and herbal products. Certain medications may interact with Dapefy S 10mg/50mg tablets, reducing effectiveness by causing undesirable side effects. 

More Information about Dapefy S 10mg/50mg Tablet

  • Store at room temperature, between 20°C to 25°C (68°F to 77°F).
  • Keep away from moisture, heat, and light.
  • It should not be frozen.
  • Keep away from children and pets.

How to consume Dapefy S 10mg/50mg Tablet

Dapefy S 10mg/50mg tablets can be administered orally in tablet form. The specific usage instructions may vary depending on the condition being treated and the form of the medication. Oral tablets are typically taken with water, as directed by the healthcare provider. 

Safety Advices for Dapefy S 10mg/50mg Tablet

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Pregnancy

  

The safety of Dapefy S 10mg/50mg tablets during pregnancy has not been extensively studied, and limited information is available regarding its use in pregnant women. So it is advisable to consult a healthcare provider before using it.

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Breast Feeding

  

The safety of Dapefy S 10mg/50mg tablets during breastfeeding has not been well studied, and limited information is available regarding its excretion into breast milk. As a result, it is recommended to exercise caution when using it while breastfeeding.

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Lungs

  

Individuals with pre-existing lung conditions must inform their healthcare provider about their medical history before starting any new medication.

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Liver

  

If you have a liver impairment or concerns about the safety of using Dapefy S 10mg/50mg tablets, discuss these with your healthcare provider. They can provide personalized guidance and ensure the most appropriate treatment plan for your medical condition.

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Alcohol

  

Dapefy S 10mg/50mg tablets with alcohol can increase the risk of certain side effects and adverse reactions. It is generally recommended to avoid or limit alcohol consumption while taking these medications.

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Driving

  

Dapefy S 10mg/50mg tablets can cause side effects that may impair driving abilities in some individuals. Therefore, caution is advised when operating a vehicle or performing any tasks that require alertness and concentration while taking these medications.

Side Effects of Dapefy S 10mg/50mg Tablet

Dapefy S 10mg/50mg tablets cause some side effects like all medications, although not everyone will experience them. 

Serious side effects:

  • Upper respiratory tract infections (colds, sore throat)
  • Headache
  • Stomach upset or nausea
  • Diarrhea
  • Hypoglycemia (low blood sugar)
  • Joint pain (arthralgia)

Common side effects:

  • Genital yeast infections (vaginal or penile)
  • Urinary tract infections (UTIs)
  • Increased urination
  • Thirst
  • Dehydration
  • Low blood pressure (hypotension)
  • Dizziness or lightheadedness
  • Increased levels of cholesterol and blood fats (hyperlipidemia)

Word of Advice

If you have prescribed Dapefy S 10mg/50mg tablets for type 2 diabetes, follow your healthcare provider's instructions carefully. Monitor for unusual symptoms, such as genital or urinary infections, and stay hydrated to prevent dehydration. Be aware of signs of diabetic ketoacidosis and seek medical attention promptly if needed. If you have kidney impairment or use sitagliptin with other diabetes medications, be cautious about potential side effects. Regularly attend follow-up appointments and communicate openly with your healthcare provider about any concerns or questions for a successful and safe diabetes management journey. 

FAQs

Q 1. What should I do if I miss a dose of Dapefy S 10mg/50mg tablets?

If you miss a dose, take it as soon as you remember unless it is close to the time of your next scheduled dose. In that case, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for the missed one. If you are unsure or have questions about missed doses, contact your healthcare provider for guidance.

Q 2. Are there any potential side effects related to the combination of Dapefy S 10mg/50mg tablets that are not typically observed with each medication individually?

While Dapefy S 10mg/50mg tablets has their own specific side effects, there are no known unique side effects associated with the combination of these medications. However, the risk of certain side effects, such as urinary tract infections or genital infections, may be increased due to the mechanism of action of dapagliflozin.

Q 3. Can Dapefy S 10mg/50mg tablets be used in older adults with type 2 diabetes?

Both Dapefy S 10mg/50mg tablets can be used in older adults with type 2 diabetes; however, individual factors and medical conditions should be considered. Older adults may have different medical needs and risk profiles, so your healthcare provider will assess your overall health and determine the most suitable treatment plan. Regular monitoring and follow-up are particularly important in this population.

Q 4. Can I take Dapefy S 10mg/50mg tablets if I have a history of recurrent urinary tract infections?

It is essential to discuss your medical history with your healthcare provider. While dapagliflozin may increase the risk of urinary tract infections, sitagliptin is not associated with such risk. Your healthcare provider will evaluate the overall benefit-risk profile and may suggest additional preventive measures or alternative medications based on your health status.

Q 5. Can Dapefy S 10mg/50mg tablets be used together with insulin or other antidiabetic medications?

Yes, Dapefy S 10mg/50mg tablets can be combined with other antidiabetic medications, including insulin, to achieve better blood glucose control in individuals with type 2 diabetes. However, adjustments in dosages or monitoring may be necessary to minimize the risk of hypoglycemia (low blood sugar) when using multiple diabetes medications together.

Fact Box of Dapefy S 10mg/50mg Tablet

Molecule name: Dapagliflozin, Sitagliptin

Therapeutic class: Antidiabetic

Pharmacological class: 

  1. Dapagliflozin: Sodium-glucose cotransporter 2 (SGLT2) inhibitors 
  2. Sitagliptin: Dipeptidyl peptidase-4 (DPP-4) inhibitor

Indications: 

1. Type 2 diabetes mellitus

2. Obese individuals with type 2 diabetes

References

  1. Mohsin Kazi et al., Development and optimization of sitagliptin and dapagliflozin loaded oral self-nanoemulsifying formulation against type 2 diabetes mellitus, [Revised on 28/12/2021] [Accessed on 19/07/2023], https://pubmed.ncbi.nlm.nih.gov/33345632/
  2. Yue Sun et al., Effects of Dapagliflozin and Sitagliptin on Insulin Resistant and Body Fat Distribution in Newly Diagnosed Type 2 Diabetic Patients [Revised on 26/4/2020] [Accessed on 19/07/2023], https://pubmed.ncbi.nlm.nih.gov/32240122/

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