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Dargen 40mcg Injection
Prescription Required
Salt Composition : Darbepoetin Alfa
Manufacturer : LUPIN LTD
Origin of Medicine : India
1 Prefilled Syringe(s)
Introduction to Dargen 40mcg Injection
Dargen 40mg injection contains the active ingredient Darbepoetin Alfa. It is an antineoplastic drug that belongs to the class of medications called hematopoietic growth factors. It is used to treat anemia (lower than normal RBC) in people with chronic kidney disease. It is also indicated to treat anemia caused by chemotherapy in people with certain types of cancer. The symptoms of anemia are fatigue, weakness, and shortness of breath.
Do not take Dargen 40mg injection if you are allergic to Darbepoetin alfa or any other ingredients and have uncontrolled blood pressure. Inform your physician if you have high blood pressure, anemia, a history of seizures, epilepsy, liver disease, or allergy to latex or hepatitis C. Inform your physician if you are pregnant or breastfeeding.
If you have severe headache, dizziness, drowsiness, confusion, problems with your eyesight, nausea, vomiting, or seizures after taking Dargen 40mg injection, inform your physician immediately and seek medical advice. This medicine's most common side effects are hypertension, shortness of breath, swelling in the legs, and cough.
Uses of Dargen 40mcg Injection
- To treat anemia in chronic kidney failure
- To treat anemia caused by chemotherapy
Therapeutic Effects of Dargen 40mcg Injection
Dargen 40mg injection is an erythropoiesis-stimulating protein produced by recombinant DNA technology. It is closely related to erythropoietin and stimulates erythropoiesis by the same mechanism, and both agents bind to progenitor stem cells stimulating the production/differentiation of red blood cells. It works by causing the bone marrow to make more red blood cells.
Interaction of Dargen 40mcg Injection with other drugs
Inform your healthcare provider about all the medicines you take, including prescription medications, over-the-counter medications, nutritional and vitamin supplements, and herbal products. Certain medications may interact with Dargen 40mg injection and reduce its effectiveness by causing undesirable side effects.
More Information about Dargen 40mcg Injection
- Store in a refrigerator (2°C to 8°C).
- Do not freeze. Store in the original package to protect from light.
- Keep the injection away from the reach of children and pets.
- If you have missed any dosing appointments, inform your doctor and schedule immediately.
How to consume Dargen 40mcg Injection
This injection is to be given under the skin (subcutaneous). Your doctor, nurse, or other healthcare professional will train you on how to inject yourself with this pre-filled pen. Do not try to inject the pre-filled pen if you are not well-trained. Never inject the medicine into your vein. If you need help to inject the medicine, visit the nearby hospital or clinic.
Safety Advices for Dargen 40mcg Injection
Pregnancy
There are no adequate and well-controlled studies on the use of Dargen 40mg injection in pregnant women. Inform your physician if you are pregnant, suspecting, or planning for pregnancy during the treatment.
Breast Feeding
Breastfeeding is not recommended in patients taking Dargen 40mg injection because the medicine passes into the breast milk in small amounts and may harm your baby.
Lungs
It is unknown whether Dargen 40mg injection can be used in patients with lung disorders. Consult your doctor if you have any lung diseases before starting the treatment.
Liver
Dargen 40mg injection is unsafe to administer in patients with liver problems. Dose adjustments are necessary. Inform your physician if you have any liver diseases or problems before initiating the therapy.
Alcohol
It is unknown whether consuming alcohol is safe during the treatment with Dargen 40mg injection. Inform your doctor if you are a chronic drinker.
Driving
Dargen 40mg injection will not make you feel tired, dizzy, or sleepy. It is safe to drive or operate heavy machinery after taking this medicine.
Side Effects of Dargen 40mcg Injection
Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them.
Common
- Swelling in the face and body
- Low blood pressure
- Abdominal pain
- Shortness of breath
- cough
Serious
- Heart problems
- Severe skin reactions
- Anemia
- Seizure attack
- Lung problems
Word of Advice
Your doctor will prescribe your exact dose and tell you how often it should be given. This medicine is given as a shot under your skin. A nurse or other health provider will give you this medicine. You may be taught how to give your medicine at home. Make sure you understand all instructions before giving yourself an injection. Do not use more medicine or use it more often than your doctor tells you to.
Do not shake the vial or syringe. You will be shown the body areas where this shot can be given. Use a different body area each time you give yourself a shot. Keep track of where you give each shot to make sure you rotate body areas. Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease, heart disease, heart failure, a blood disorder, cancer, any infection, bleeding, or a history of blood clots, heart attack, stroke, or seizures.
FAQs
Q 1. Can Dargen 40mg injection be used in patients with kidney failure who are undergoing dialysis?
Yes, Dargen 40mg injection is commonly used in patients with kidney failure who are undergoing dialysis to manage anemia.
Q 2. Can Dargen 40mg injection be used in patients with a history of heart disease?
Dargen 40mg injection should be used with caution in patients with a history of heart disease, as it may increase the risk of certain cardiovascular events. It is crucial to discuss the potential risks and benefits with a healthcare provider before initiating treatment.
Q 3. Can Dargen 40mg injection be used to treat anemia caused by nutritional deficiencies?
Dargen 40mg injection is not typically used to treat anemia caused by nutritional deficiencies. It is primarily used for anemia related to chronic kidney disease, cancer chemotherapy, and other specific conditions. Nutritional deficiencies require appropriate dietary changes and/or supplementation.
Q 4. Can Dargen 40mg injection be used to treat anemia in patients undergoing radiation therapy?
Dargen 40mg injection is used to treat anemia in patients undergoing chemotherapy, depending on the specific circumstances and the healthcare provider's recommendation. The anemia is typically managed through a comprehensive treatment plan determined by the oncology team.
Q 5. Can Dargen 40mg injection interact with other medications?
Dargen 40mg injection may interact with certain medications, such as blood thinners or immunosuppressants. It is important to inform the healthcare provider about all medications, including over-the-counter drugs and supplements, to avoid potential interactions or adverse effects.
Fact Box of Dargen 40mcg Injection
Molecule name: Darbepoetin Alfa | Therapeutic class: Antineoplastics |
Pharmacological class: Hematopoietic growth factors | Indications: 1. To treat anemia in chronic kidney failure 2. To treat anemia caused by chemotherapy |
References
- Aranesp solution for injection in pre-filled pen (SureClick) - Summary of Product Characteristics (SmPC) - (emc). www.medicines.org.uk. Published March 2022. Accessed May 10, 2023. http://www.medicines.org.uk/emc/product/6958/smpc
- Darbepoetin Alfa.; Revised June 2011. Accessed May 10, 2023. https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/103951orig1s5173_103951orig1s5258lbl.pdf
- Goodman & Gilman’s, The Pharmacological Basis of Therapeutics, Hematopoietic agents, 12th edition, 1071 - 1072.
- KD Tripathi, Essentials of Medical Pharmacology, Haematinics and Erythropoietin, 7th edition, 2013, 611.
Disclaimer
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