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E2V Gel
Prescription Required
Salt Composition : Estradiol
Manufacturer : GLAND PHARMA LTD
Origin of Medicine : India
1 Tube Of 80gm
Introduction to E2v Gel
E2V Gel contains an active ingredient called estradiol which belongs to a group of medicines called vaginal Hormone Replacement Therapy (HRT). It falls within the category of hormones known as estrogens and shares identical properties with the naturally occurring estradiol synthesized by women's ovaries.
It is indicated to treat menopausal symptoms such as 'vaginal atrophy' (dryness or irritation of the vagina) in elderly women who have passed the stage of menopause.
It is not recommended to use E2V Gel if you are allergic to the active compound estradiol and its constituents. It is not advised to use E2V Gel if you have breast cancer or any type of cancer that is oestrogen receptor sensitive. It is not recommended to use E2V Gel if you have a clotting disorder or blood clot in veins (lungs or legs) and unexplained vaginal bleeding.
It is not advised to consume E2V Gel if you have a heart attack, stroke, angina or abnormal liver function tests. It is not given to patients with a rare inherited blood disorder called porphyria. The risk of gallbladder disease is elevated by estrogen intake. Stop using estrogen if you experience cholestatic jaundice, severe hypertriglyceridemia, severe hypercalcemia, or vision loss. It is advised to keep an eye on women receiving thyroid replacement treatment.
Inform your doctor if you have vaginal bleeding, heart, kidney, lung or liver problems, diabetes, asthma, high blood pressure, or hearing disorder. Consult your doctor if you are planning to get pregnant or think you may be pregnant or while you are breastfeeding. Speak with your doctor about your medical history to the doctor. It is necessary to inform your healthcare provider regarding all the medicines you are taking including herbal, vitamin and over the counter medicines.
Uses of E2v Gel
- Relieve menopausal symptoms of 'vaginal atrophy' (in the vagina such as dryness or irritation)
- Treatment for hypogonadism, castration, or primary ovarian failure-related hypoestrogenism
- Preventing osteoporosis after menopause
Therapeutic Effects of E2v Gel
E2V Gel primarily acts by binding to estrogen receptors (ERs) present on the surface of target cells. Upon binding to its receptor, E2V Gel induces a conformational change in the receptor, leading to its activation. E2V Gel replaces estrogen (female sex hormone) and prevents the symptoms of menopause, like vaginal irritation or dryness.
Interaction of E2v Gel with other drugs
Inform your doctor about any prescribed medications, over-the-counter medicines, nutritional or vitamin supplements, and herbal products you take or have taken before the treatment. Certain medications may interact with E2V Gel and can cause undesirable side effects.
More Information about E2v Gel
- Protect from moisture
- Store E2V Gel at 25˚C
- Keep children away from the sight and reach of this medication.
How to consume E2v Gel
Take E2V Gel exactly as prescribed by your healthcare provider. Do not adjust the dosage or frequency without consulting your doctor. Apply your E2V Gel at the same time each day to maintain a consistent level of hormone in your body.
Safety Advices for E2v Gel
Pregnancy
The medicine is not recommended for pregnant women. Notify your healthcare professional if you are pregnant or planning to have a baby think you may be pregnant.
Breast Feeding
It is unknown whether E2V Gel is excreted in breast milk. Consult your doctor before using it. Seek your doctor for more information.
Lungs
Inform your physician about any underlying lung disorders before taking E2V Gel, as this medication should be used cautiously in lung disease patients.
Liver
Inform your physician about any underlying liver disorders before taking E2V Gel, as this medication should be used cautiously in liver disease patients.
Alcohol
It is unknown whether it is safe to consume alcohol under medication. So, it is recommended to consult your doctor before taking medicine.
Driving
It is unknown whether E2V Gel alters driving ability. However, if you experience side effects like tiredness or drowsiness, avoid driving and using machines.
Side Effects of E2v Gel
Side effects are unwanted symptoms caused by medicines. Even though all medicines cause side effects, not everyone gets them.
Common
- Headache
- Stomach pain
- Vaginal bleeding
- Discharge or discomfort.
Serious:
- Ovarian cancer
- Blood clots
- Heart attack
- Breast lumps
- Stroke
Word of Advice
It is recommended to examine your breast (mammogram) to avoid the risk of breast cancer caused by the drug and inform your doctor if you have any changes in skin color. Always make sure that you have washed your hands before and after the use of the gel. Don't apply it on your breast, eye, or other part of the body apart from the application site. Inform your doctor if you have uterus cancer or a history of blood clots. It is advised to regularly monitor liver function tests, thyroid tests, bone mineral density and blood pressure as treatment with E2V Gel can alter these values.
FAQs
Q 1. What are the precautions I need to take while taking E2V Gel?
Inform your medical history to the doctor. It will be useful for him to treat you based on your health. Inform your doctor if you have kidney, liver, or heart disease, diabetes, gallbladder problems, or asthma before starting to use the medicine.
Q 2. Can I suddenly stop taking E2V Gel?
Stopping your E2V Gel treatment suddenly without first talking to your doctor is not advised. When estrogen medication is abruptly stopped, withdrawal symptoms and maybe rebound effects might occur. Talk to your healthcare practitioner about stopping or altering your therapy so that a safe and gradual plan may be created.
Q 3. Can I take E2V Gel if I have a history of allergies to it?
Consult your doctor if you are allergic to E2V Gel or any of the ingredients before starting the medicine.
Fact Box of E2v Gel
Molecule name: Estradiol | Therapeutic class: Hormones |
Pharmacological class: Androgens | Indications:
|
Dosage form: Gel | Habit forming: No |
References
- Mercury Pharmaceuticals Limited, Electronics Medicines Compendium (EMC), [Revised on Jan 2024], [Accessed on 13th March 2024] , https://www.medicines.org.uk/emc/files/pil.11779.pdf
- Ther-Rx Corporation, US Food and Drug Administration,[Revised on April 2008], [Accessed on 13th March 2024], https://www.accessdata.fda.gov/drugsatfda_docs/label/2008/022014s001lbl.pdf
- Pfizer, [Revised on Feb 2024], [Accessed on 13th March 2024], https://labeling.pfizer.com/ShowLabeling.aspx?id=595
- Novartis Pharmaceuticals Corporation, [Revised on October 2021], [Accessed on 13th March 2024], https://www.novartis.com/us-en/sites/novartis_us/files/Vivelle_DOT.pdf
- KD Tripathi, Essentials of Medical Pharmacology, Androgens and drugs for erectile dysfunction, 7th edition, 2013, 296-300.
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