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Eligard Depot 45mg Injection
Prescription Required
Salt Composition : Leuprolide Acetate
Manufacturer : EMCURE PHARMACEUTICALS LTD
Origin of Medicine : India
1 Vial(s)
Introduction to Eligard Depot 45mg Injection
Eligard Depot 45mg injection consists of the active ingredient Leuprolide acetate. It belongs to the class of medicines called gonadotropin-releasing hormone (GnRH) agonists. This injection treats prostate cancer in men, hormone-responsive breast cancer, endometriosis (tissue that usually lines the interior of the uterus grows outside of it), and uterine fibroids (noncancerous growths of the uterus) in women. This medicine is also used for the treatment of premature puberty, which is characterized by early physical development in children due to hormonal imbalances.
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Do not receive this injection if you are allergic to Eligard Depot 45mg injection or its ingredients, including Goserelin and Triptorlin. Before receiving this medicine, inform your physician if you have a liver or kidney impairment. Inform your doctor if you have undiagnosed abnormal uterine bleeding. Do not take this treatment if you are pregnant or planning to get pregnant. During the treatment, the existing symptoms may worsen due to the sex steroid increase in the body. Talk to your physician for more concerns. Report to your doctor if your child has a progressive brain tumor. Â
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Before starting the treatment, notify your doctor about your underlying medical conditions, such as diabetes, seizures, heart problems with chest pain, irregular heartbeats, depression, or are at increased risk of thinning of bones (osteoporosis). This medicine is not recommended for patients with abnormal vaginal bleeding. If you are a woman of childbearing age, use non-hormonal contraceptives while taking Eligard Depot 45mg injection. Report to your doctor if you are a man with urinary obstruction or had an operation to remove your testicles. Tell your doctor if you feel pressure on the spinal cord and experience urinary disorders and haematuria (blood in the urine).
Uses of Eligard Depot 45mg Injection
- Prostate cancer
- Hormone-responsive breast cancer in perimenopausal (around menopause) women
- Endometriosis (a painful illness in which the tissue that normally lines the inside of the uterus grows outside of your uterus)
- Central precocious puberty (a child’s body begins to change into an adult too soon caused by a release of certain hormones)
Therapeutic Effects of Eligard Depot 45mg Injection
Eligard Depot 45mg injection decreases testosterone or estrogen production, depending on the treated condition. This helps to slow the growth of cancer cells, reduce the size of uterine fibroids, and alleviate the symptoms of endometriosis and early onset of puberty.
Interaction of Eligard Depot 45mg Injection with other drugs
Inform your healthcare provider about all the medicines you take, including prescription, over-the-counter, nutritional and vitamin supplements, vaccines, and herbal products. Certain medications such as Quinidine, Procainamide, Amiodarone, Sotalol, Pain killers, and Antibiotics may interact with the effects of Eligard Depot 45mg injection and reduce its effectiveness by causing undesirable side effects.Â
More Information about Eligard Depot 45mg Injection
- Keep Eligard Depot 45mg injection out of sight and reach of children.
- Store in a cool, dry place, away from direct heat and light.
- Store below 25°C
- Do not refrigerate or freeze
How to consume Eligard Depot 45mg Injection
Eligard Depot 45mg injection is usually administered in the arm, thigh, or abdomen. If this injection is recommended for you, it will be given by a healthcare professional. Do not self-administer. Your physician will choose the dosage and administration frequency based on the medical condition because it differs for each person.
Safety Advices for Eligard Depot 45mg Injection
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Pregnancy
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It is unsafe to use Eligard Depot 45mg injection because it is contraindicated in pregnant women. Tell your doctor if you are pregnant or planning to get pregnant before taking this treatment.Â
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Breast Feeding
 ÂEligard Depot 45mg Injection is contraindicated in breastfeeding women. Inform your doctor if you are breastfeeding before taking this injection.
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Lungs
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It is unknown whether Eligard Depot 45mg is safe for patients with lung problems. Notify your physician if you have any lung disease before starting the treatment. Contact your doctor if you experience any lung-related symptoms.
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Liver
  Eligard Depot 45mg injection should be used cautiously in patients with liver impairment. Consult your doctor before receiving it. Notify your doctor about underlying liver conditions.Â
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Alcohol
 ÂConsuming alcohol during the Eligard Depot 45mg injection treatment may increase the risk of thinning bones (osteoporosis). Hence caution should be taken. Consult your doctor for more information
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Driving
  Eligard Depot 45mg Injection can cause drowsiness, visual disturbances, or dizziness. It is unsafe; hence avoid driving if you are unwell.
Side Effects of Eligard Depot 45mg Injection
Side effects are unwanted symptoms caused by medicines. Even though all medicines cause side effects, not everyone gets them.
Serious
- Severe rash, itching
- Shortness or difficulty of breath
- Cough with blood
- Pulmonary embolism
- Severe headache
Common
- Altered blood sugar and cholesterol levels
- Injection site reactions
- Loss of appetite
- Abnormal liver function
- Swelling in ankle or hand
- Difficulty sleeping, headache
- Mood swings, depression
- Weight changes
- Nausea, vomiting
- Vaginal dryness, bleeding
- Loss of interest in sexual intercourse
- Hot flushes
- Bone pain, muscle weakness
- Breast tenderness
Word of Advice
During the treatment of breast cancer with Eligard Depot 45mg injection, it is recommended to undergo regular checkups every three months in combination with an aromatase inhibitor. Do not receive this injection if you experience any abnormal vaginal bleeding. Consult your doctor immediately if you or your child is suffering from a headache even after treating it with pain killer, vision problems, buzzing, or ringing in the ear. If you have diabetes, ask your doctor to monitor your glucose and blood sugar levels regularly. Before starting, inform your doctor if you are still mensurating.Â
FAQs
Q 1. How does Eligard Depot 45mg injection work?
Eligard Depot 45mg injection decreases testosterone or estrogen production, depending on the treated condition. This helps to slow the growth of cancer cells, reduce the size of uterine fibroids, and alleviate the symptoms of endometriosis and early onset of puberty.
Q 2. Who should not use Eligard Depot 45mg injection?
Eligard Depot 45mg injection should not be used by pregnant and breastfeeding women, people who are allergic to the medication, or people with a history of osteoporosis or bone fractures. It should also be used cautiously in people with a past of depression or mental illness.
Q 3. What should I do if I miss a dose of Eligard Depot 45mg?
If you miss a dose of Eligard Depot 45mg, contact your healthcare provider as soon as possible to schedule the missed dose. Do not double up on doses to make up for a missed one.
Q 4. Can Eligard Depot 45mg cause weight gain?
Weight gain is not a common side effect of Eligard Depot 45mg, but it may occur in some people.
Q 5. How does Eligard Depot 45mg help with endometriosis?
Eligard Depot 45mg reduces estrogen production and helps relieve endometriosis symptoms by inhibiting tissue growth outside the uterus.
Fact Box of Eligard Depot 45mg Injection
Molecule name: Leuprolide acetate  | Therapeutic class: Antineoplastics |
Pharmacological class: Gonadotropin-Releasing Hormone (GnRH) agonists | Indication: 1. Prostate cancer 2. Hormone-responsive breast cancer in perimenopausal (around menopause) women 3. Endometriosis (a painful illness in which the tissue that normally lines the inside of the uterus grows outside of your uterus) 4. Central precocious puberty (a child’s body begins to change into an adult too soon caused by a release of certain hormones) |
References
- Goodman & Gilman’s, The Pharmacological Basis of Therapeutics, Introduction to Endocrinology: The hypothalamic-pituitary axis, 12th edition, 2011, 1122.
- KD Tripathi, Essentials of Medical Pharmacology, Anterior pituitary hormones, 7th edition, 2013, 243.
- Takeda UK Limited, Electronic medicines compendium (emc), [ Revised on June 2022] [ Accessed on 12th April 2023], https://www.medicines.org.uk/emc/product/4651/smpc
- Abbott Laboratories, US Food and Drug Administration, [Issued on Feb 2016] [ Accessed on 12th April 2023], https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/020517s036_019732s041lbl.pdf
Disclaimer
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