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Enbrel 25mg Injection
Prescription Required
Salt Composition : Etanercept
Manufacturer : PFIZER LTD
Origin of Medicine : United States of America
2 Prefilled Syringe(s) Of 10ml
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Introduction to Enbrel 25mg Injection
Enbrel 25mg Injection contains an active component as Etanercept. It is commercially known as Enbrel and is a potent TNF inhibitor utilized to treat various autoimmune conditions, including rheumatoid arthritis, psoriasis, psoriatic arthritis, ankylosing spondylitis, and juvenile idiopathic arthritis. Rheumatoid arthritis is an autoimmune disorder characterized by chronic inflammation of the joints, leading to pain, swelling, and potential joint deformity. Psoriatic arthritis is an inflammatory joint condition occurring in some individuals with psoriasis, leading to joint pain, stiffness, and swelling. Ankylosing spondylitis is a type of arthritis that primarily affects the spine, causing pain, stiffness, and potential fusion of the vertebrae, leading to reduced flexibility. Juvenile idiopathic arthritis is a group of chronic arthritic conditions affecting children under 16, causing joint inflammation, pain, and potential damage.Â
Enbrel 25mg Injection suppresses the immune system's overactive response and reduces inflammation, effectively improving the symptoms of these chronic inflammatory diseases. While this medication has demonstrated remarkable efficacy in managing these conditions, it is not without potential side effects, which may include injection site reactions, infections, headaches, and allergic reactions. When considering its usage in specific populations, Enbrel 25mg Injection can be prescribed for pediatric and elderly patients. It is approved for use in children with juvenile idiopathic arthritis and, when appropriately administered, can be beneficial in managing symptoms in older adults affected by autoimmune diseases. However, as with any medication, cautious monitoring and individualized treatment plans are essential for pediatric and elderly patients to optimize safety and effectiveness.
Uses of Enbrel 25mg Injection
Enbrel 25mg Injection is used to treat the following:
- Rheumatoid arthritis
- Plaque psoriasis
- Psoriatic arthritis
- Ankylosing spondylitis
- Juvenile idiopathic arthritis
- Non-radiographic axial spondyloarthritis
Therapeutic Effects of Enbrel 25mg Injection
Enbrel 25mg Injection's mechanism of action involves its role as a tumor necrosis factor (TNF) inhibitor. By binding to circulating TNF-alpha and acting as a decoy receptor, this medication disrupts the inflammatory signaling pathway, suppressing immune cell activation and reducing the production of inflammatory cytokines. This neutralization of TNF-alpha effectively mitigates inflammation, making it highly effective.
Interaction of Enbrel 25mg Injection with other drugs
Inform the doctor about your medicines, including prescription, over-the-counter, nutritional or vitamin supplements, and herbal products. Certain medications may interact with Enbrel 25mg Injection, reducing effectiveness by causing undesirable side effects.Â
More Information about Enbrel 25mg Injection
- Store at room temperature, between 36°F to 46°F (2°C to 8°C)
- Keep away from moisture, heat, and light.
- It should not be frozen.
- Keep away from children and pets.
How to consume Enbrel 25mg Injection
Enbrel 25mg Injection can be administered via subcutaneous injection and intravenous infusion. The choice of administration route depends on the patient's condition, preferences, and the healthcare provider's recommendation, both of which have been proven effective in treating autoimmune diseases.
Safety Advices for Enbrel 25mg Injection
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Pregnancy
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The safety of Enbrel 25mg Injection during pregnancy is not fully established, and its use should be carefully discussed with a healthcare provider, weighing potential risks and benefits for each case.
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Breast Feeding
 ÂThe safety of Enbrel 25mg Injection during breastfeeding is not fully established. It is recommended to consult with a healthcare provider to assess potential risks and benefits before using the medication while breastfeeding.
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Lungs
  If you are having any problems related to the lungs, it's essential to inform your healthcare provider about any existing medical conditions before starting Enbrel 25mg Injection treatment.
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Liver
  Caution is advised when using Enbrel 25mg Injection in individuals with liver impairment, as the drug is metabolized in the liver. Patients with significant liver damage require close monitoring, considering the potential risk of increased drug levels and adverse effects.Â
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Alcohol
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It is generally advisable to limit alcohol consumption while on this medication to avoid potential interactions or adverse effects.Â
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Driving
  Some patients may experience dizziness, fatigue, or other side effects that could impair their ability to drive safely.Â
Side Effects of Enbrel 25mg Injection
Enbrel 25mg Injection causes some side effects like all medications, although not everyone will experience them.Â
Serious:
- Serious infections
- Tuberculosis (TB) reactivation
- Hepatitis B reactivation
- Neurological events
- Allergic reactions
Common:
- Injection site reactions
- Upper respiratory infections
- Headache
- Nausea
Word of Advice
Enbrel 25mg Injection increases the risk of serious infections, including tuberculosis and hepatitis B reactivation, and may lead to neurological events. Patients with a history of malignancy, heart failure, autoimmune disorders, or liver impairment should be closely monitored. Live vaccines should be avoided, and non-live vaccines may have reduced efficacy. Use in pregnant and breastfeeding women should be carefully considered. This medication should not be combined with other biological therapies. Close monitoring and prompt reporting of adverse reactions are essential for safe and effective treatment. Patients scheduled for surgery may need to discontinue the drug temporarily. Regular screening and communication with healthcare providers are vital to managing potential risks and optimizing treatment outcomes.
FAQs
Q 1. Are there any serious side effects associated with Enbrel 25mg Injection?
Yes, Enbrel 25mg Injection may have serious side effects, including an increased risk of serious infections, tuberculosis and hepatitis B reactivation, and rare neurological events. Patients with a history of malignancy or heart failure should also be cautious.
Q 2. Can I receive vaccinations while on Enbrel 25mg Injection?
Live vaccines should be avoided while on Enbrel 25mg Injection treatment due to the risk of infection. Non-live vaccines may have reduced effectiveness, and the timing of vaccinations should be discussed with the healthcare provider.
Q 3. How often will I need to be monitored while on Enbrel 25mg Injection?
Regular monitoring is essential while on Enbrel 25mg Injection therapy. This includes evaluating the response to treatment, assessing for any side effects, and monitoring for signs of infections, liver function, and other potential complications.
Q 4. Can I discontinue Enbrel 25mg Injection if my symptoms improve?
It is essential not to discontinue Enbrel 25mg Injection without consulting your healthcare provider. Stopping the medication abruptly may lead to a flare-up of your condition. Any changes to the treatment plan should be discussed with your healthcare provider.
Q 5. Can I travel with Enbrel 25mg Injection?
Traveling with Enbrel 25mg Injection may be possible, depending on the destination and duration of travel. Some formulations may allow short-term storage at room temperature, while others require refrigeration. Patients should consult with their healthcare provider or pharmacist for specific travel recommendations.
Q 6. Can I switch to Enbrel 25mg Injection from another biologic medication?
Switching from one biologic medication to another should be done under the guidance of a healthcare provider. The transition may require specific considerations and monitoring to ensure safety and effectiveness.
Fact Box of Enbrel 25mg Injection
Molecule name: Etanercept | Therapeutic class: Immunomodulatory Agent |
Pharmacological class: Tumor Necrosis Factor (TNF) Inhibitor.
| Indications:Â 1. Rheumatoid arthritis 2. Plaque psoriasis 3. Psoriatic arthritis 4. Ankylosing spondylitis 5. Juvenile idiopathic arthritis 6.Non-radiographic axial spondyloarthritis |
References
- KD Tripathi, Essentials of Medical Pharmacology, Anti rheumatoid and Antigout Drugs, 7th edition, 2013,212.
- Goodman & Gilman’s, The Pharmacological Basis of Therapeutics, Dermatological Pharmacology, 12th edition, 2011, 1826.
- Pfizer, Electronic medicines compendium (EMC), [Revised on 17 May 2023] [Accessed on 29 July 2023], https://www.medicines.org.uk/emc/product/3837/smpc#grefÂ
- Pfizer, US Food and Drug Administration, [Revised on Dec 2017] [Accessed on 29th July 2023], https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/103795s5556lbl.pdf Â
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