Enhertu 100mg Injection

• Treats HER2-positive breast cancer that is metastatic or unresectable for patients who have had prior anti-HER2 treatments.
• Effective for HER2-low metastatic breast cancer after prior chemotherapy.
• Treats HER2-mutated non-small cell lung cancer (NSCLC) that is metastatic or unresectable following prior treatment.
• Used for HER2-positive gastric or gastroesophageal junction (GEJ) adenocarcinoma after prior trastuzumab-based therapy.
• For HER2-positive (IHC 3+) metastatic solid tumours when no other satisfactory treatments are available.

Enhertu 100mg Injection works in a targeted way to treat certain cancer cells. It is made up of two main parts:

1. Monoclonal Antibody: This part of the medication specifically attaches to cancer cells that have the HER2 protein on their surface. These are known as HER2-positive cancer cells, which are common in some breast and stomach cancers.

2. DXd (Drug Conjugate): This is the other active component of Enhertu 100 mg Injection. DXd is a powerful substance that can kill cancer cells.

Enhertu 100 mg Injection finds and attaches to HER2-positive cancer cells. Once attached, it delivers the DXd directly into these cancer cells. The DXd then works to kill these cells from the inside. This targeted approach helps attack the cancer cells while sparing many healthy cells in the body.

Inform your physician about all the prescribed medicine, over-the-counter medications, nutritional or vitamin supplements, and herbal supplements you have taken before. Certain medications may interact with Enhertu 100mg Injection and can cause undesirable side effects. 

• Store in the refrigeratorat refrigerator between 2°C to 8°C.
• Do not freeze.
• It should be kept away from children and pets.

Enhertu 100mg Injection is administered through an intravenous (IV) infusion by a healthcare provider every three weeks. Before each treatment, you may receive medication to prevent nausea and vomiting. If you have an infusion-related reaction, the infusion may be slowed, paused, or permanently stopped for severe reactions. If you miss a dose, it's important to contact your healthcare provider immediately to reschedule. The number of treatments will depend on your healthcare provider's assessment.

Side effects are unwanted symptoms caused by medicines. Even though all medicines cause side effects, not everyone gets them. 

Serious:

• Severe allergic reactions (rashes, itching, difficulty in breathing, fever)

Common:

• Nausea (feeling sick), vomiting
• Tiredness
• Decreased appetite
• Blood tests showing decreased red or white blood cells or platelets
• Hair loss
• Diarrhoea
• Constipation
• Blood tests showing increased levels of the liver enzymes such as transaminases
• Pain in muscles and bones
• Weight loss
• Fever
• Abdominal (belly) pain
• Infections of the nose and throat, including flu-like symptoms
• Headache
• Blisters in or around your mouth
• Cough
• Blood tests showing low blood potassium levels
• Indigestion
• Breathing difficulties
• Swelling of ankles and feet
• Nosebleed
• Altered/bad taste in the mouth
• Infection of the lungs

If you are taking Enhertu 100mg Injection, it is crucial to regularly monitor your lung and liver functions with your doctor due to potential side effects. Both women and men should use effective contraception during treatment. Women should continue using birth control for at least seven months after the final dose of Enhertu 100mg Injection, while men should do so for four months after completing treatment to avoid risks to their partners who may become pregnant. It's essential to consult with your doctor about the best contraceptive methods and inform them before you decide to stop using contraception. Additionally, male patients should be aware that Enhertu 100mg Injection may impact fertility, so it is advisable to avoid fathering a child for four months after treatment and discuss sperm preservation options with your doctor before starting the medication.