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Fibrinorel 1gm Injection
Prescription Required
Salt Composition : Fibrinogen
Manufacturer : RELIANCE LIFE SCIENCES PVT LTD
Origin of Medicine : India
1 Vial(s)
Introduction to Fibrinorel 1gm Injection
Fibrinorel 1gm Injection contains an active component called as human fibrinogen. It treats bleeding episodes in people with a congenital Fibrinogen deficiency. These deficiencies can be caused by genetic mutations or by liver disease. It can be used as an adjunct to hemostasis (blood clotting) in adults undergoing surgery when control of bleeding by standard surgical techniques is ineffective or impractical. It is also used to help stop the bleeding and prevent further blood loss in cases of massive hemorrhage. It can be given to women who risk delivering their babies prematurely. It is also used in patients with acquired fibrinogen deficiency, which can be caused by liver disease, disseminated intravascular coagulation (DIC), afibrinogenemia, hypofibrinogenemia or other conditions that damage the liver or interfere with its production.
If you have had an allergic reaction to Fibrinorel 1gm Injection or other blood products in the past, you should not receive it. It should not be given to people who are already actively bleeding. This is because it can increase the risk of forming a blood clot. If you have a history of thrombosis, you should not receive this medication without careful consideration. Special considerations are needed when administering this medication to pediatric and geriatric patients, including dosage adjustments based on age and weight and close monitoring.
Uses of Fibrinorel 1gm Injection
- Fibrinogen replacement therapy for bleeding disorders
- Coagulation management in liver diseases
- Disseminated intravascular coagulation (DIC)
- Afibrinogenmia
- Hypofibrinogenemia
Therapeutic Effects of Fibrinorel 1gm Injection
Fibrinorel 1gm Injection molecules are converted into fibrin by the enzyme thrombin. Fibrin strands form a meshwork, trapping blood cells and creating a stable blood clot at the site of injury or bleeding. This clot helps to staunch bleeding and promote wound healing. The missing Fibrinorel 1gm Injection enhances the body's ability to form these essential blood clots, preventing excessive bleeding in individuals with Fibrinorel 1gm Injection deficiency disorders.
Interaction of Fibrinorel 1gm Injection with other drugs
Inform the doctor about your medicines, including prescription, over-the-counter, nutritional or vitamin supplements, and herbal products. Certain medications may interact with Fibrinorel 1gm Injection, reducing effectiveness by causing undesirable side effects.
More Information about Fibrinorel 1gm Injection
- Stored at room temperature from 2°C to 8°C.
- Keep away from moisture, heat, and light.
- It should not be frozen.
- Keep away from children and pets.
How to consume Fibrinorel 1gm Injection
Fibrinorel 1gm Injection can be administered through several routes, including intravenous (IV), intramuscular (IM), and, in some cases, intraarterial (IA). The healthcare provider determines the choice of administration route based on the patient's needs and the urgency of treatment.
Safety Advices for Fibrinorel 1gm Injection
Pregnancy
There is not enough information about the safety of Fibrinorel 1gm Injection concentrates in pregnant women. So consult your doctor before using it.
Breast Feeding
Fibrinorel 1gm Injection concentrate is generally safe to take while breastfeeding. However, talking to your doctor before taking any breastfeeding medication is important.
Lungs
Before using Fibrinorel 1gm Injection in individuals with lung conditions, consult with a healthcare provider if you have lung conditions.
Liver
If you have liver conditions, consult a healthcare provider before using Fibrinorel 1gm Injection.
Alcohol
It is not safe to take Fibrinorel 1gm Injection with alcohol. Alcohol can interfere with how Fibrinorel 1gm Injection works and increase the risk of bleeding.
Driving
If you have Fibrinorel 1gm Injection deficiency and you need to drive, it is important to talk to your doctor. Your doctor may recommend that you take it before driving.
Side Effects of Fibrinorel 1gm Injection
Fibrinorel 1gm Injection causes some side effects like all medications, although not everyone will experience them.
Serious
- Allergic Reactions
- Transfusion-related acute lung injury (TRALI)
- Transfusion-associated circulatory overload (TACO)
- Transfusion-transmitted infections
- Thrombosis
- Fluid overload
Common
- Fever
- Chills
- Flushing
- Nausea
- Headache
- Mild allergic reactions (itching, hives)
Word of Advice
It is essential to assess patients for allergies, potential allergic reactions, and underlying medical conditions like cardiovascular, liver, or kidney diseases, as these factors can impact Fibrinorel 1gm Injection. Medication interactions, especially with anticoagulants or antiplatelet drugs, must be considered, and dosages adjusted accordingly. Thrombocytopenia, kidney dysfunction, and multiple transfusions can affect treatment response and require close monitoring. Patients receiving it from human plasma should be informed of the minimal risk of viral transmission.
FAQs
Q 1. Is Fibrinorel 1gm Injection therapy a lifelong treatment for congenital Fibrinorel 1gm Injection deficiency?
For individuals with congenital fibrinogen deficiency, Fibrinorel 1gm Injection therapy is often required throughout their lifetime to prevent bleeding episodes. The treatment plan is tailored to the patient's specific needs.
Q 2. Can Fibrinorel 1gm Injection therapy cause blood clots (thrombosis)?
While Fibrinorel 1gm Injection therapy promotes clot formation, it must be administered carefully to avoid excessive clotting (thrombosis). Patients at risk of thrombosis or with a history of clotting disorders should be monitored during treatment.
Q 3. Is it safe to receive too much Fibrinorel 1gm Injection?
Yes, excessive Fibrinorel 1gm Injection therapy can lead to an increased risk of thrombosis (clot formation). Healthcare providers closely monitor fibrinogen levels during treatment to ensure they remain within the desired range.
Q 4. Can Fibrinorel 1gm Injection be used in rare bleeding disorders other than fibrinogen deficiency?
Fibrinorel 1gm Injection may be considered in rare bleeding disorders characterized by dysfunction in fibrinogen function or in cases of acquired fibrinogen deficiencies due to underlying medical conditions.
Q 5. Is it safe to resume Fibrinorel 1gm Injection after experiencing side effects?
Whether to continue Fibrinorel 1gm Injection after experiencing side effects should be carefully evaluated by healthcare providers. In some cases, therapy may be resumed with precautions, while alternative treatments may be considered in others.
Fact Box of Fibrinorel 1gm Injection
Molecule name: Fibrinogen | Therapeutic class: Coagulation Factor Replacement |
Pharmacological class: Hemostatic Agent | Indications: 1. Fibrinogen-I Injection replacement therapy for bleeding disorders 2. Coagulation management in liver diseases 3. Disseminated intravascular coagulation (DIC) 4. Afibrinogenemia 5. Hypofibrinogenemia |
References
- KD Tripathi, Essentials of Medical Pharmacology, Drugs affecting coagulation, Bleeding and Thrombosis, 7th edition, 2013, 616.
- Grifols UK Ltd, Electronic medicines compendium (EMC), [Revised on 4th August 2023] [Accessed on 8th September 2023], https://www.medicines.org.uk/emc/files/pil.5909.pdf
- Octapharma USA Inc, US Food and Drug Administration, [Revised on Dec 2020] [Accessed on 8th September 2023], https://www.fda.gov/media/105864/download
Disclaimer
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