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Fistent 250mg Injection
Prescription Required
Salt Composition : Fulvestrant
Manufacturer : ADLEY FORMULATIONS
Origin of Medicine : India
1 Prefilled Syringe(s)
Introduction to Fistent 250mg Injection
Fistent 250mg injection contains the active substance fulvestrant. It is an antineoplastic drug that belongs to the class estrogen receptor antagonist. Estrogen, a type of female sex hormone, can sometimes be involved in the growth of breast cancer. This medicine is used alone to treat postmenopausal women with a certain type of breast cancer called estrogen receptor-positive breast cancer that is locally advanced or spread to other parts of the body. It is also indicated in combination with other anti-cancer medication to treat women with certain types of breast cancer called hormone receptor-positive, human epidermal growth factor receptor 2-negative breast cancer, which is locally advanced or spread to other parts of the body.Â
Do not take this injection if you are allergic to fulvestrant or any other ingredients of this medicine, pregnant or breastfeeding, or have severe liver problems. Before initiating the treatment, inform your physician if you have kidney or liver problems, bone diseases, bleeding disorders, and heart diseases. Fistent 250mg injection is not indicated in children and adolescents under 18 years. Report to your physician if you have allergic reactions, including swelling of the face, lips, tongue, or throat, after administering this injection.Â
Common side effects of Fistent 250mg injection are pain or inflammation at the site of injection, abnormal levels of liver enzymes, nausea, headache, cough, weakness or tiredness, joint and muscle pain, hot flashes, hair loss, and skin rash. Your doctor may advise you to take certain blood tests while receiving this injection. This injection may increase your risk of bleeding and liver failure. Female patients of reproductive potential should use effective contraception during treatment with this injection and for two years after the last dose.
Uses of Fistent 250mg Injection
- Treat Hormone receptor (HR)-positive, human epidermal growth receptor 2 (HER2)-negative breast cancer in postmenopausal women.
Therapeutic Effects of Fistent 250mg Injection
Many breast cancers have estrogen receptors (ER), and the growth of these tumors can be stimulated by estrogen. Fistent 250mg injection is an estrogen receptor antagonist that binds to the estrogen receptors in cancer cells and works by blocking the action of estrogen on cancer cells. This can slow or stop the growth of tumor cells.  Â
Interaction of Fistent 250mg Injection with other drugs
Inform your healthcare provider about all the medicines you take, including prescription medications, over-the-counter medications, recent vaccinations, nutritional and vitamin supplements, and herbal products. Certain medications may interact with Fistent 250mg injection and reduce its effectiveness by causing undesirable side effects.Â
More Information about Fistent 250mg Injection
- Store Fistent 250mg injection in the refrigerator (2°C to 8°C)
- Do not freeze
- keep the injection away from the reach of children and pets.
- If you have missed any dosing appointments, inform your doctor and schedule immediately.
How to consume Fistent 250mg Injection
It should only be administered by a trained doctor or nurse as a slow intramuscular injection. Do not self-administer the injection. Your doctor will decide the dose and duration of the treatment based on your disease severity and other factors.Â
Safety Advices for Fistent 250mg Injection
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Pregnancy
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Fistent 250mg injection is unsafe to administer in pregnant women because it may affect the fetus. Inform your physician if you are pregnant, suspect pregnancy, or planning to become pregnant. Using an effective birth control method during the treatment and for 2 years after your last dose is necessary. Â
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Breast Feeding
 ÂBreastfeeding is not recommended in patients taking Fistent 250mg injection because the medicine passes into the breast milk in small amounts and may harm your baby.Â
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Lungs
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It is unknown whether Fistent 250mg injection can be used in patients with lung disorders. Consult your doctor if you have any lung diseases before starting the treatment.
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Liver
  Fistent 250mg injection is unsafe when administered in patients with severe liver diseases. Dose adjustments are necessary in moderate liver failure. Inform your physician if you have liver problems before initiating the therapy. Â
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Alcohol
 ÂConsuming alcohol may affect the effectiveness of the Fistent 250mg injection. Stop consuming alcohol if you are taking this medicine.Â
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Driving
  Fistent 250mg injection does not affect the ability to drive. Please consult your doctor for more advice.
Side Effects of Fistent 250mg Injection
Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them.Â
 Common
- Constipation, diarrhea
- Loss of appetite
- Nausea, vomiting
- Decreased RBC, WBC, and Platelets
- Infections
- Joint and muscle pain
- Backache, bone pain
- Weakness, tiredness
- Headache
- Cough, difficulty breathing
- Hot flushes
- Pain at the site of injection
Serious
- Changes in heart rhythm
- Severe neutropenia(decreased WBC)
- Liver failure, inflammation of liver
- Hypersensitivity reaction
- Swelling in the body
Word of Advice
Inform your physician if you have vaginal bleeding, especially at starting of the therapy. This medicine is given as a shot into one of your muscles. Fistent 250mg injection should be used with caution in patients with severe kidney disease. This medicine needs to be given on a fixed schedule; if you miss a dose inform your doctor immediately. Do not breastfeed during treatment and for one year after your last dose. This medicine may cause infertility. Talk to your doctor before using this medicine if you plan to have children.Â
FAQs
Q 1. What side effects should I report immediately while taking Fistent 250mg injection?
Allergic reactions like itching. Swelling in your face or hands, tingling in mouth or throat, chest tightness, difficulty in breathing, fever, chills, cough, sore throat, body aches, unusual bleeding, bruising, or weakness should be informed to your doctor immediately.
Q 2. How long should I have to take Fistent 250mg injection?
Fistent 250mg injection is given as a cycle therapy. Your doctor will decide the dose and duration of the therapy based on your disease severity and condition.
Q 3. What if Fistent 250mg injection does not work for me?
There are alternative medicines that may work for you based on your disease condition and other factors. Your doctor will decide the alternative treatment tha works best for you.
Q 4. Does Fistent 250mg injection cause bone loss?
Fistent 250mg injection can cause side effects such as bone density loss and bone pain. If these side effects persist for a long time, consult a doctor.
Q 5. Is there any special diet that I should follow while taking Fistent 250mg injection?
Unless your doctor advises you to avoid certain foods, follow a healthy diet. Please consult your doctor for more advice on food and diet.
Fact Box of Fistent 250mg Injection
Molecule name: Fulvestrant | Therapeutic class: Antineoplastics |
Pharmacological class: Estrogen receptor antagonist | Indications: Treat certain type of breast cancer in postmenopausal women |
References
- Faslodex 250 mg solution for injection - Summary of Product Characteristics (SmPC) - (emc). www.medicines.org.uk. [2020] [cited 2023 Mar 21]. Available from: https://www.medicines.org.uk/emc/product/68
- HIGHLIGHTS OF PRESCRIBING INFORMATION. [2017] [cited 2023 Mar 21]. Available from: https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/021344s034lbl.pdf
- Goodman & Gilman’s, The Pharmacological Basics of Therapeutics, Estrogens and progestins, 12th edition, 2011, 1177.
Disclaimer
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