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Fragmin 2500IU Injection
Prescription Required
Salt Composition : Dalteparin
Manufacturer : PFIZER LTD
Origin of Medicine : United States of America
1 Prefilled Syringe(s) Of 0.2ml
Introduction to Fragmin 2500iu Injection
Fragmin 2500IU Injection contains an active component as dalteparin. It is a medication used to prevent and treat blood clots. It is a type of anticoagulant, specifically a low molecular weight heparin (LMWH). This medication works by inhibiting the formation of blood clots, which can help reduce the risk of conditions like deep vein thrombosis (DVT) and pulmonary embolism. Deep vein thrombosis (DVT) is a blood clot that forms in a deep vein, usually in the legs. At the same time, pulmonary embolism is a serious condition that occurs when a clot travels to the lungs, potentially causing life-threatening complications.
Fragmin 2500IU Injection has a more predictable anticoagulant response than unfractionated heparin, allowing for easier dosing and monitoring. It has a longer half-life, which means less frequent dosing is required compared to other anticoagulants, leading to better patient compliance. Unlike warfarin, which requires frequent international normalized ratio (INR) level monitoring, this medication typically does not need such monitoring. This medication has a lower bleeding risk than other anticoagulants, making them safer for certain patient populations.Â
Individuals with a history of hypersensitivity or allergic reactions to Fragmin 2500IU Injection or other heparins should not use this medication. It is an anticoagulant that can increase the risk of bleeding. It should be used cautiously in patients with a history of bleeding disorders or active bleeding. Patients with severe kidney impairment may require dosage adjustments or alternative treatments, as this medication is primarily eliminated through the kidneys. It should be used cautiously in patients undergoing spinal or epidural anesthesia or lumbar puncture, as it may increase the risk of epidural or spinal hematomas, leading to paralysis.
Uses of Fragmin 2500iu Injection
- Deep vein thrombosis (DVT)
- Pulmonary embolism (PE).
- Prevention of blood clots in medical setting
Therapeutic Effects of Fragmin 2500iu Injection
The mechanism of action of Fragmin 2500IU Injection involves its ability to bind to antithrombin III, a natural anticoagulant in the body. This binding enhances antithrombin III's ability to inactivate clotting factors, particularly factor Xa and, to a lesser extent, thrombin. By inhibiting these key clotting factors, this medication effectively prevents the formation of blood clots. It reduces the risk of thromboembolic events, such as deep vein thrombosis (DVT) and pulmonary embolism (PE).
Interaction of Fragmin 2500iu Injection with other drugs
Inform the doctor about your medicines, including prescription, over-the-counter, nutritional or vitamin supplements, and herbal products. Certain medications may interact with Fragmin 2500IU Injection, reducing effectiveness by causing undesirable side effects.
More Information about Fragmin 2500iu Injection
- Store at room temperature, between 20°C to 25°C (68°F to 77°F).
- Keep away from moisture, heat, and light.
- It should not be frozen.
- Keep away from children and pets.
How to consume Fragmin 2500iu Injection
Fragmin 2500IU Injection is typically administered as a subcutaneous injection (under the skin). The exact dosing and administration schedule will depend on the medical condition being treated, the patient's weight, and other individual factors. It is essential to follow the instructions provided by your healthcare professional or pharmacist carefully.
Safety Advices for Fragmin 2500iu Injection
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Pregnancy
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Pregnant women or those planning to become pregnant should discuss all potential risks and benefits of using Fragmin 2500IU Injection with their healthcare provider. The decision to use this medication during pregnancy should be made collectively, considering the specific medical condition and individual circumstances.
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Breast Feeding
 ÂThe safety of Fragmin 2500IU Injection during breastfeeding should be assessed individually, and healthcare providers can tailor treatment plans to suit the needs of both the mother and the baby.
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Lungs
  If you have a pre-existing lung condition or lung disease, it's essential to inform your healthcare provider before starting Fragmin 2500IU Injection or any other anticoagulant.
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Liver
  If you have liver-related medical conditions, such as liver disease or liver dysfunction, it is crucial to inform your healthcare provider about your condition before starting Fragmin 2500IU Injection or any other medication.
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Alcohol
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Combining Fragmin 2500IU Injection with alcohol is generally not recommended. Alcohol can interact with this medication. This combination can be dangerous and may lead to serious side effects.
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Driving
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Fragmin 2500IU Injection is an anticoagulant medication that is used to prevent and treat blood clots, and it does not typically cause drowsiness or impairment of motor skills that would directly affect driving ability.
Side Effects of Fragmin 2500iu Injection
Fragmin 2500IU Injection causes some side effects like all medications, although not everyone will experience them.Â
Serious:
- Signs of bleeding
- Black or bloody stools
- Coughing up blood or blood clots
- Severe headache or weakness, especially on one side of the body
- Sudden vision changes
- Severe abdominal or back pain
- Severe or persistent dizziness or fainting
- Signs of an allergic reaction, including rash, itching, swelling
Common:
- Bruising at the injection site
- Mild pain or redness at the injection site
- Bleeding from the gums or nose
- Mild stomach upset or nausea
- Mild headache
- Itching or skin rash
Word of Advice
Before using Fragmin 2500IU Injection, inform your healthcare provider about any bleeding disorders, history of heparin-induced thrombocytopenia, kidney or liver impairment, and any ongoing medications or medical conditions. Be vigilant for signs of bleeding, such as easy bruising or prolonged bleeding from cuts, and report any severe or persistent side effects promptly. Caution is advised when undergoing spinal or epidural anesthesia, as Fragmin 2500IU Injection may increase the risk of spinal or epidural hematomas. Regular monitoring of blood clotting factors may be necessary, especially during surgery or invasive procedures. Avoid alcohol abuse, which can further increase bleeding risk. The use during pregnancy and breastfeeding should be carefully assessed, and if you are planning long-distance travel, consult your healthcare provider for travel-related precautions. Follow all healthcare provider's instructions and attend follow-up appointments to ensure safe and effective treatment with Fragmin 2500IU Injection.
FAQs
Q 1. Are there any medications or conditions that interact with Fragmin 2500IU Injection?
Yes, certain medications, such as other anticoagulants, antiplatelet drugs, and NSAIDs, can interact with Fragmin 2500IU Injection. Conditions like bleeding disorders, kidney or liver impairment, and heparin-induced thrombocytopenia may also affect Fragmin 2500IU Injection use.
Q 2. Can I undergo surgery or invasive procedures while on Fragmin 2500IU Injection?
Inform your healthcare provider if you are scheduled for surgery or invasive procedures while taking Fragmin 2500IU Injection. Depending on the procedure and bleeding risk, the timing or dosage of Fragmin 2500IU Injection may need adjustment or alternative anticoagulation strategies may be used.
Q 3. How long do I need to take Fragmin 2500IU Injection?
The duration of Fragmin 2500IU Injection treatment will depend on the medical condition being treated and individual factors. In some cases, it may be used for a short period, such as during hospitalization for surgery or medical treatment. For others, especially those at high risk of recurrent blood clots, long-term therapy may be required. Your healthcare provider will determine the appropriate treatment duration for your situation.
Q 4. Can I switch from Fragmin 2500IU Injection to another anticoagulant?
Switching from Fragmin 2500IU Injection to another anticoagulant should only be done under the guidance of a healthcare professional. Stopping or changing medications without proper management may increase the risk of blood clots or bleeding complications. Always consult your healthcare provider before making any changes to your anticoagulant therapy.
Q 5. Can I self-administer Fragmin 2500IU Injection injections at home?
Sometimes, patients may be trained to self-administer Fragmin 2500IU Injection injections at home. This approach allows for more convenient and flexible treatment, especially for long-term use. However, self-administration should only be done after proper training and approval from your healthcare provider. It's essential to follow the correct injection technique and dosing instructions to ensure effective and safe treatment.
Q 6. What are the common side effects of Fragmin 2500IU Injection?
Common side effects of Fragmin 2500IU Injection may include bruising at the injection site, mild pain or redness, bleeding from the gums or nose, mild stomach upset, headache, itching, or skin rash. These side effects are generally less severe and temporary.
Fact Box of Fragmin 2500iu Injection
Molecule name: Dalteparin | Therapeutic class: Anticoagulant |
Pharmacological class: Anticoagulant
| Indications:Â 1. Deep vein thrombosis (DVT) 2. Pulmonary embolism (PE) 3. Prevention of blood clots in medical setting |
References
- KD Tripathi, Essentials of Medical Pharmacology, Drugs affecting Coagulation, Bleeding and Thrombosis, 7th edition, 2013, 619.
- Goodman & Gilman’s, The Pharmacological Basis of Therapeutics, Blood coagulation and Anticoagulant, Fibrinolytic and Antiplatelet drugs, 12th edition, 2011, 858.
- Pfizer, Electronic medicines compendium (EMC), [Revised on 22 Feb 2023] [Accessed on 30th July 20203], https://www.medicines.org.uk/emc/product/4247/pil#gref
- Pfizer, US Food and Drug Administration, [ Revised on May 2019] [ Accessed on 30th July 2023], https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/020287s072lbl.pdf
Disclaimer
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