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Glivec 400mg Tablet
Prescription Required
Salt Composition : Imatinib
Manufacturer : NOVARTIS INDIA LTD
Origin of Medicine : Switzerland
10 Tablet(s) In A Strip
Introduction to Glivec 400mg Tablet
Glivec 400mg tablet contains the active substance imatinib. It is an antineoplastic drug that belongs to the class tyrosine kinase inhibitor. This tablet is used in treating adults and children with chronic myeloid leukemia (CML- it is a form of leukemia in which certain abnormal white blood cells start growing out of control). It is also indicated to treat Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph-positive ALL). It is also used to treat certain types of gastrointestinal stromal tumors (GIST, a type of tumor that grows in the walls of the digestive passages and may spread to other parts of the body).Â
Glivec 400mg tablet is also used to treat myelodysplastic/myeloproliferative diseases (MDS/MPD); these are a group of blood diseases in which some blood cells start growing out of control. They also treat hypereosinophilic syndrome (HES) and/or chronic eosinophilic leukemia (CEL); these are blood diseases in which some blood cells (eosinophils) start growing out of control. This medicine is also intended to treat dermatofibrosarcoma protuberans (DFSP), a cancer of the tissue beneath the skin in which some cells start growing abnormally. It works to inhibit the growth of these abnormal blood cells. Â
Do not take Glivec 400mg tablet if you are allergic to imatinib or any other ingredients of this medicine. Before initiating the treatment, inform your physician if you have kidney, heart, or liver problems, if you have thyroid problems, or if your thyroid gland has been removed. Notify your doctor if you ever had or have a hepatitis B infection because this medicine could cause the hepatitis B to become active again. Report any symptoms of bruising, bleeding, fever, fatigue, and confusion when taking this medicine. This medicine may cause fertility problems. Â
Uses of Glivec 400mg Tablet
- Chronic myeloid leukemia (CML)
- Philadelphia chromosome positive acute lymphoblastic leukemia (ph-positive ALL)
- Myelodysplastic/myeloproliferative diseases (MDS/MPD)
- Hypereosinophilic syndrome (HES)
- Chronic eosinophilic leukemia (CEL)
- Dermatofibrosarcoma protuberans (DFSP)
- Gastrointestinal stromal tumors (GIST)
Therapeutic Effects of Glivec 400mg Tablet
Glivec 400mg tablet is a protein-tyrosine kinase inhibitor that blocks a specific abnormal protein created by a chromosomal abnormality that signals cancer cells to multiply. It inhibits the multiplication and induces cell death in abnormal cancer cells.Â
Interaction of Glivec 400mg Tablet with other drugs
Inform your healthcare provider about all the medicines you take, including prescription medications, over-the-counter medications, nutritional and vitamin supplements, and herbal products. Certain medications may interact with the effects of Glivec 400mg tablet and reduce its effectiveness by causing undesirable side effects. Inform your physician, especially if you are using medicines that prevent the formation of blood clots.
More Information about Glivec 400mg Tablet
- Store Glivec 400mg tablet in room temperature (25°C)
- Keep the injection away from the reach of children and pets.
- If you forgot to take a dose, take it as soon as you remember. However, if it is nearly time for the next dose, skip the missed dose.
- Do not take a double dose to make up for a forgotten dose.
- Avoid direct contact with crushed tablets with the skin or mucous membrane. If such contact occurs, wash thoroughly.
How to consume Glivec 400mg Tablet
Your doctor will decide the dose and duration of the treatment based on your disease condition, severity, and other factors. Take the tablets as prescribed by your doctor. Do not break, crush, or chew the tablets. Swallow the tablet whole with a glass of water. Take this medicine with a meal to avoid stomach problems. If you are unable to swallow the tablets, you can dissolve them as per your doctor's advice.Â
Safety Advices for Glivec 400mg Tablet
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Pregnancy
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Glivec 400mg tablet is unsafe to administer in pregnant women because it may affect the fetus. Inform your physician if you are pregnant, suspect pregnancy, or planning to become pregnant. Using an effective birth control method during the treatment and for 15 days after your last dose is necessary. Â
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Breast Feeding
 ÂBreastfeeding is not recommended in patients taking Glivec 400mg tablet because the medicine passes into the breast milk in small amounts and may harm your baby.Â
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Lungs
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It is unknown whether Glivec 400mg tablet can be used in patients with lung disorders. Consult your doctor if you have any lung diseases before starting the treatment.
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Liver
  Glivec 400mg tablet is unsafe when administered in patients with severe liver diseases. Dose adjustments are necessary in severe liver failure. Inform your physician if you have liver problems before initiating the therapy. Â
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Alcohol
 ÂIt is unknown whether it is safe to consume alcohol when taking Glivec 400mg tablet. Consult your doctor for more advice.
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Driving
  It is unsafe to drive or operate heavy machinery after taking Glivec 400mg tablet because you may feel dizzy, drowsy, or get blurred vision.
Side Effects of Glivec 400mg Tablet
Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them.Â
Common
- Swelling in the face, legs, ankle, and feet
- Nausea, vomiting
- Muscle cramps and pain
- Diarrhea
- Skin rash, night sweats
- Tiredness, dizziness
- Abdominal pain
- Increased weight
- Decreased RBC and WBC cells
- Headache
- Cough, Inflammation in the nose
- Fever, lack of sleep
Serious
- Heart failure
- GI disorders
- Hypothyroidism
- Liver failure
- Swelling in the body
Word of Advice
You may become more sensitive to the sun while taking Glivec 400mg tablets. It is important to cover sun-exposed areas of skin and use sunscreen with a high sun protection factor after consulting with your doctor. The medicine should be administered cautiously in patients with kidney problems. This tablet may cause your body to retain water, inform your physician if you put on weight very quickly after the therapy. Your doctor will regularly do lab tests to check whether the medicine works. Do not breastfeed during the treatment with this medicine and for 15 days after your last dose.
FAQs
Q 1. How to use Glivec 400mg tablet?
Glivec 400mg tablet is administered orally, in the form of a tablet or capsule, and the dose depends on several factors, including the condition being treated, the weight of the patient, the particular regimen being used, and the overall health of the patient. It should be taken with food and a large glass of water to minimize gastrointestinal irritation.
Q 2. Ever since I started using Glivec 400mg tablet, I have noticed rashes and severe itching when I have sun exposure. Is it because of the medicine or the disease?
This medicine may make your skin much more sensitive to sunlight than it normally is. Exposure to sunlight may cause skin rash, itching, redness, or severe sunburn. When you are outdoors, wear protective clothing and use sunscreen with an SPF. Consult your doctor before taking necessary precautions.
Q 3. Can Glivec 400mg tablet cause kidney damage?
Yes, when taken for a longer period the medicine may cause damage to your kidneys. Your doctors may recommend you take a routine blood tests to assess your kidney function.
Q 4. When is the best time to take Glivec 400mg tablet?
Take the tablet as prescribed by your doctor. Take Glivec 400mg tablet at the same time every day. It is usually taken with a meal and a large glass of water to avoid stomach problems.
Q 5. Does Glivec 400mg tablet affect memory?
Memory impairments have been only reported in limited studies. Consult your doctor immediately if you have any trouble in concentrating.
Fact Box of Glivec 400mg Tablet
Molecule name: Imatinib | Therapeutic class: Antineoplastics |
Pharmacological class: Tyrosine kinase inhibitor | Indications: Treat certain type of leukemia and other cancers and disorders of the blood cells. |
References
- Imatinib 400mg film-coated tablets - Summary of Product Characteristics (SmPC) - (emc). www.medicines.org.uk. [revised on 2020] [cited 2023 Mar 23]. Available from: https://www.medicines.org.uk/emc/product/2297/smpc
- HIGHLIGHTS OF PRESCRIBING INFORMATION. [revised on 2016] [cited 2023 Mar 23]. Available from: https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/021588s047lbl.pdf
- KD Tripathi, Anticancer Drugs, Essentials of Medical Pharmacology, 8th Edition, 2019, 915-936.
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