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Gonal-F 75IU Injection
Prescription Required
Salt Composition : Follitropin Alfa
Manufacturer : MERCK LTD
Origin of Medicine : Germany
1 Prefilled Pen Device(s)
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Introduction to Gonal-f 75iu Injection
Gonal-F 75IU injection contains an active component as Follitropin alfa. It is a medication used in assisted reproductive technologies (ART) to treat infertility in both men and women. This synthetic form of follicle-stimulating hormone (FSH) plays a crucial role in stimulating the development of eggs in females and sperm in males. Infertility in men and women refers to the inability to conceive after a year of regular unprotected intercourse. It stimulates the development of multiple follicles in women, enhances sperm production in men, and provides precise timing for optimal ovulation. With proven efficacy and a generally safe profile, it brings hope to infertile couples, increasing pregnancy rates and shortening treatment duration.
Individuals with a known hypersensitivity or allergic reaction to Gonal-F 75IU injection or any of its components should avoid its use. Allergic reactions are rare but possible, requiring immediate medical attention. Women with ovarian cysts or tumors should avoid Gonal-F 75IU injection, as it may exacerbate these conditions. Patients with uncontrolled hypothyroidism or adrenal dysfunction should not use Gonal-F 75IU injection. Uncontrolled hypothyroidism refers to a state where the levels of thyroid hormones remain inadequately regulated, causing persistent symptoms and potential complications. Individuals with abnormalities or blockages in the reproductive tract that prevent successful egg or sperm transport may not benefit from this medication.is not generally recommended for pediatric or elderly populations.
Uses of Gonal-f 75iu Injection
Gonal-F 75IU injection is used in the following:
- Assisted Reproductive Technologies (ART)
- Ovulation Induction
- Treatment of Male Infertility
- Hypogonadism
Therapeutic Effects of Gonal-f 75iu Injection
Gonal-F 75IU injection, a recombinant follicle-stimulating hormone (FSH), exerts its mechanism of action by binding to the FSH receptors on the ovarian granulosa cells in females or Sertoli cells in males. This binding stimulates the growth and development of ovarian follicles in women, leading to the maturation of eggs, and in men, it promotes the production and maturation of sperm. By mimicking the natural FSH, this medication helps regulate reproductive processes, making it valuable in infertility treatments and other related conditions.
Interaction of Gonal-f 75iu Injection with other drugs
Inform the doctor about your medicines, including prescription, over-the-counter, nutritional or vitamin supplements, and herbal products. Certain medications may interact with Gonal-F 75IU injection, reducing effectiveness by causing undesirable side effects.Â
More Information about Gonal-f 75iu Injection
- Store at room temperature, between 2°C to 8°C (36°F to 46°F).
- Keep away from moisture, heat, and light.
- It should not be frozen.
- Keep away from children and pets.
How to consume Gonal-f 75iu Injection
Gonal-F 75IU injection is administered through subcutaneous injection. Patients are typically provided with clear instructions and guidance on how to administer the injections safely and effectively during their treatment period.
Safety Advices for Gonal-f 75iu Injection
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Pregnancy
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Gonal-F 75IU injection is not recommended for use during pregnancy. If pregnancy occurs during treatment with this medication or any other fertility medications, it is crucial to inform the healthcare provider immediately
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Breast Feeding
 ÂGonal-F 75IU injection is not recommended for use during breastfeeding. It is essential to to consult with a healthcare provider before considering its use during breastfeeding.
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Lungs
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Gonal-F 75IU injection may not have direct adverse effects on the lungs, any medication can potentially cause side effects. It is important to discuss any concerns or existing lung conditions with your healthcare provider before starting this medication.
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Liver
  If you have liver-related medical conditions. It is important to consult with a healthcare professional before using Gonal-F 75IU injection if you have any liver-related concerns.
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Alcohol
 ÂExcessive alcohol consumption can have negative effects on the liver and may interact with Gonal-F 75IU injection's metabolism. It is best to avoid alcohol consumption or limit it to moderate levels while taking it.Â
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Driving
  Gonal-F 75IU injection may cause headache, nausea, and dizziness.If you experience any of these side effects consult your healthcare provider.
Side Effects of Gonal-f 75iu Injection
Gonal-F 75IU injection causes some side effects like all medications, although not everyone will experience them.Â
Serious:
- Severe Skin ReactionsOvarian Hyperstimulation Syndrome (OHSS)
- Allergic Reactions
- Ectopic Pregnancy
- Blood Clots
Common:
- Injection Site Reactions
- Abdominal Discomfort
- Nausea
- Headache
- Fatigue
Word of Advice
Patients should be mindful of potential risks of Gonal-F 75IU injection, including Ovarian Hyperstimulation Syndrome (OHSS), multiple pregnancies, and ectopic pregnancy. Women with asthma or respiratory conditions should use it with care, and patients with pre-existing heart conditions should be closely monitored. Fertility treatments can have emotional effects, necessitating adequate psychological support. Patients must inform their healthcare providers of their complete medical history, and proper handling, dosage adjustment, and monitoring are essential. Regular ultrasound examinations and adherence to prescribed dosages are crucial, and patients should be attentive to potential risks and seek counseling and support during treatment. Other considerations include travel precautions, drug disposal, and informed consent to ensure the safest and most effective use of the medication.
FAQs
Q 1. Is fertility preservation recommended before starting Gonal-F 300IU injection treatment?
For patients who may face risks to future fertility due to the underlying condition or treatment, fertility preservation options may be considered before starting Gonal-F 300IU injection treatment. Patients should discuss this possibility with their healthcare provider.
Q 2. What are the chances of success with Gonal-F 300IU injection treatment?
Success rates with Gonal-F 300IU injection treatment can vary depending on individual factors such as age, the underlying cause of infertility, and overall health. Patients should have realistic expectations and discuss success rates with their healthcare providers.
Q 3. Can lifestyle changes improve the effectiveness of Gonal-F 300IU injection treatment?
Maintaining a healthy lifestyle, including regular exercise, a balanced diet, and stress management, can support overall well-being and may positively impact fertility treatment outcomes.
Q 4. Is there a risk of ovarian hyperstimulation syndrome (OHSS) with Gonal-F 300IU injection?
Yes, OHSS is a possible complication of Gonal-F 300IU injection treatment, particularly in women undergoing fertility treatments. Patients at higher risk for OHSS should be closely monitored.
Q 5. What happens if a dose of Gonal-F 300IU injection is missed?
If a dose of Gonal-F 300IU injection is missed, patients should consult their healthcare provider for specific guidance. It is essential to follow the recommended dosing schedule to ensure the best treatment outcomes.
Q 6. Can the effectiveness of Gonal-F 300IU injection be affected by age?
Age can significantly affect the effectiveness of Gonal-F 300IU injection treatment. In general, fertility declines with age, and the chances of successful outcomes may vary in older individuals.
Fact Box of Gonal-f 75iu Injection
Molecule name: Follitropin alfa | Therapeutic class: Fertility drug |
Pharmacological class: Gonadotropin-releasing hormone (GnRH) agonist
| Indications:Â 1. Assisted Reproductive Technologies (ART) 2. Ovulation Induction 3. Treatment of Male Infertility 4. Hypogonadism |
References
- KD Tripathi, Essentials of Medical Pharmacology, Anterior pituitary hormones, 7th edition, 2013, 241.
- Goodman & Gilman’s, The Pharmacological Basis of Therapeutics, Introduction to Endocrinology: The Hypothalamic-Pituitary Axis, 12th edition, 2011, 1123.
- Merck Europe BV, Electronic medicines compendium (EMC), [Revised on 17th Nov 2022] [Accessed on 2nd August 2023], https://www.medicines.org.uk/emc/product/2218/smpc#gref
- Serono, US Food and Drug Administration, [Revised on Dec 2020 ] [Accessed on 2nd August 2023], https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/020378s045,s067,s075lbl.pdf
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