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Grastim 300mcg Injection
Prescription Required
Salt Composition : Filgrastim
Manufacturer : DR REDDY'S LABORATORIES LTD
Origin of Medicine : India
1 Prefilled Syringe(s)
Introduction to Grastim 300mcg Injection
Grastim 300mcg injection contains the active constituent filgrastim. It is a white blood cell growth factor (granulocyte-colony stimulating factor) approved by the FDA to decrease the risk of developing febrile neutropenia ( occurrence of fever or infection associated with low WBC count) and to reduce the duration of neutropenia (low white blood cell count) in people who have non-myeloid cancer and are receiving chemotherapy drugs. It is also used to increase the number of WBC and decrease the length of time of fever in people with acute myeloid leukemia.Â
It is also used in people undergoing bone marrow transplants and in people with severe chronic neutropenia (low number of neutrophils in the blood). Grastim 300mcg injection is also used to prepare the blood for leukapheresis (a treatment in which certain blood cells are removed from the blood). It is also indicated to increase the chance of survival in people exposed to harmful amounts of radiation, which can cause severe damage to the bone marrow. Other uses include in patients with advanced HIV infection, which will help to reduce the risk of infections.Â
Grastim 300mcg injection belongs to the class of medications called colony-stimulating factors. They work by helping the body to produce more White blood cells. WBC are important because they help your body fight infection. These cells are highly sensitive to the effects of chemotherapy, which might cause a decrease in the number. If your WBC decreases, your body may not have enough cells to combat bacteria, putting you at risk of infection. Inform your physician if you have or had liver disease, kidney problems, sickle cell anemia, or bone disease. Common side effects include fever, pain, rash, cough, shortness of breath, and nosebleed.
Uses of Grastim 300mcg Injection
- To prevent infections after chemotherapy due to decreased white blood cells (neutropenia)
Therapeutic Effects of Grastim 300mcg Injection
Grastim 300mcg injection is a colony-stimulating factor that acts on blood-forming cells by binding to specific cell surface receptors, thereby inducing cell division, multiplication, and cell functional activation.Â
Interaction of Grastim 300mcg Injection with other drugs
Inform your healthcare provider about all the medicines you take, including prescription medications, over-the-counter medications, nutritional or vitamin supplements, and herbal products. Certain medications may interact with Grastim 300mcg injection and reduce effectiveness by causing undesirable side effects.Â
More Information about Grastim 300mcg Injection
- Store Grastim 300mcg injection in a refrigerator (2°C – 8°C). Do not freeze.
- Do not shake the pre-filled syringe.
- Discard the medicine if stored at room temperature for more than 48 hours.
- Keep it out of reach from children and pets.
- It is important to get the dose at the scheduled time. If you missed the schedule, contact your doctor immediately for advice.
How to consume Grastim 300mcg Injection
Grastim 300mcg injection is available as a prefilled syringe. A qualified healthcare professional will administer the injection in the fatty tissues just under your skin (subcutaneously) or it will be administered as an intravenous injection into your vein slowly. The dose, route of administration, and frequency will be decided by your doctor based on your disease condition and other factors. Â
If your physician decides that you or your caregiver can administer the Grastim 300mcg injection at home, then read the “Instructions for use” carefully from the package insert with the medicine. Your doctor or other healthcare professionals will train you on self-administration. Do not administer the medicine if you have not been trained and are not sure about the administration procedure.Â
Safety Advices for Grastim 300mcg Injection
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Pregnancy
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Grastim 300mcg injection is unsafe when administered during pregnancy because it may cause birth defects in your baby. Consult your doctor if you are pregnant or planning for pregnancy during the treatment.
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Breast Feeding
 ÂIt is unsafe to breastfeed during the treatment with this Grastim 300mcg injection because it may cause harm to the baby. Please consult your doctor before breastfeeding.Â
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Lungs
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It is unknown whether Grastim 300mcg injection can be administered to patients with lung problems. Consult your doctor if you have any lung diseases before starting the treatment.
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Liver
  It is unknown whether Grastim 300mcg injection can be administered in patients with liver disorders. Inform your physician if you have any liver problems before starting treatment with this Injection.Â
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Alcohol
 ÂIt is unsafe to consume alcohol with Grastim  300mcg injection. Please consult your doctor for more advice.
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Driving
  It is unsafe to travel, drive vehicles, or operate heavy machinery after taking (1 hour) Grastim 300mcg injection. Please consult your doctor.Â
Side Effects of Grastim 300mcg Injection
Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them.
 Common
- Pain in the bones, joints, and muscles
- Pain at the site of Injection
- Fever
- Itchiness and skin rash
- Nausea
- Headaches
- Dizziness and tiredness
- Nose bleeding
- Hair fall
 Serious
- Inflammation of Aorta
- Capillary leak syndrome (plasma leaks out of tiny blood vessels)
- Hypersensitivity reactions
- Changes in urine color
- Swelling in hands, feet, face, and abdomen
- Difficulty in breathing
- Sickle cell anemia
Word of Advice
Inform your physician if you are experiencing any symptoms of swelling in the face, feet, hands, and abdomen, difficulty in breathing, sudden drop in blood pressure, left abdominal pain, weakness, and skin rashes. If you use the prefilled syringe, allow the medicine to warm for 30 minutes at room temperature before injecting. Read the package insert carefully if you are self-administering the medicine. This medicine may cause lung, liver, or kidney problems. Your physician may advise you to take laboratory tests regularly to monitor the effectiveness of the therapy.
FAQs
Q 1. What are the symptoms that I should notify the physician while taking Grastim 300mcg injection?
Inform your physician if you are experiencing any symptoms of swelling in the face, feet, hands, and abdomen, difficulty in breathing, sudden drop in blood pressure, left abdominal pain, weakness, and skin rashes.
Q 2. What is the Grastim 300mcg injection package insert?
The FDA provides a package insert, which summarizes the relevant scientific information needed for healthcare practitioners and patients to use the drug safely and effectively. The package insert contains safety information, instruction for use, and other information.
Q 3. Who should not take Grastim 300mcg injection?
Grastim 300mcg injection is not indicated for everyone. Do not take this medicine if you are allergic to any forms of rubber, latex, pegfilgrastim, filgrastim or any of the other ingredients in this medicine.
Q 4. Will Grastim 300mcg injection affect my kidneys?
This medicine may affect your kidneys. Regular kidney function tests will be taken to monitor your kidney functions. Inform your physician if you have any kidney problems.
Q 5. Can I breastfeed while taking Grastim 300mcg injection?
No, This medicine secretes in small amounts in breast milk. Grastim 300mcg injection can cause harm to your baby. Please consult your doctor if you are breastfeeding.
Fact Box of Grastim 300mcg Injection
Molecule name: Filgrastim | Therapeutic class: Hematopoietic |
Pharmacological class: colony-stimulating factor | Indications:Â Neutropenia |
References
- Neupogen Singleject 30 MU (0.6 mg/ml) - Patient Information Leaflet (PIL) - (emc) ww.medicines.org.uk. [Revised on 2022] [cited 2023 Mar 14]. Available from: https://www.medicines.org.uk/emc/product/608/pil
- Neupogen 30 MU (0.3 mg/ml) solution for injection - Patient Information Leaflet (PIL) - (emc). www.medicines.org.uk. [Revised on 2022] [cited 2023 Mar 14]. Available from: https://www.medicines.org.uk/emc/product/3000/pil
- KD Tripathi, Essentials of Medical Pharmacology, Anticancer drugs, 7th edition, 2013, 876
Disclaimer
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