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Hamsyl 3750IU Injection
Prescription Required
Salt Composition : Pegaspargase
Manufacturer : EMCURE PHARMACEUTICALS LTD
Origin of Medicine : India
1 Vial(s) Of 5ml
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Introduction to Hamsyl 3750iu Injection
Hamsyl 3750IU Injection is a chemotherapy drug containing the active constituent Pegaspargase. It is used to treat a type of blood cancer called Acute Lymphoblastic Leukemia (ALL). This is a white blood cell cancer in which the immature white cells start growing out of control, thus preventing the production of functional blood cells. Combined with other chemotherapy drugs, this medication can help increase the chances of remission and long-term survival for people with ALL. It is particularly effective in treating children with ALL, who have a higher remission rate and overall survival when included in their treatment plan.Â
Hamsyl 3750IU Injection is typically used with other chemotherapy agents to treat ALL, particularly in patients who have not responded to other treatments or who have relapsed after initial treatment. Glucose intolerance can occur with the administration of Hamsyl 3750IU Injection. Contact your doctor if you experience severe headaches, abdominal pain, excessive thirst, or serious allergic reactions while taking this medicine. Patients with previous kidney and pancreatic disease should talk to their healthcare provider before taking this medication.
Uses of Hamsyl 3750iu Injection
Hamsyl 3750IU Injection is indicated to treat the following conditions:
- Acute Lymphoblastic Leukemia
- Non-Hodgkin's Lymphoma
Therapeutic Effects of Hamsyl 3750iu Injection
Hamsyl 3750IU Injection is an enzyme that breaks down the amino acid asparagine in the body. Cancer cells require asparagine to grow and divide and cannot produce their asparagine. By breaking down asparagine in the body, this medication can effectively "starve" cancer cells of this essential nutrient, slowing their growth and promoting cancer cell death. However, normal cells in the body can produce their asparagine and are not as affected by the enzyme as cancer cells. Therefore, this medicine selectively targets cancer cells while sparing healthy cells in the body to some extent.
Interaction of Hamsyl 3750iu Injection with other drugs
Hamsyl 3750IU Injection is an enzyme that breaks down the amino acid asparagine in the body. Cancer cells require asparagine to grow and divide and cannot produce their asparagine. By breaking down asparagine in the body, this medication can effectively "starve" cancer cells of this essential nutrient, slowing their growth and promoting cancer cell death. However, normal cells in the body can produce their asparagine and are not as affected by the enzyme as cancer cells. Therefore, this medicine selectively targets cancer cells while sparing healthy cells in the body to some extent.
More Information about Hamsyl 3750iu Injection
- Store in a refrigerator at 2-8°C.
- Do not freeze.
- Protected from light.
- Keep it in its original packaging until it is ready to be used.
- Keep out of the reach of children and pets.
- Should be disposed of properly.
How to consume Hamsyl 3750iu Injection
Hamsyl 3750IU Injection is typically administered by a healthcare provider as an intravenous (IV) injection in a clinical setting. The dosage and frequency of infusions will vary depending on the patient's medical condition, age, weight, and other factors. You should not take a double dose to make up for the second dose.
Safety Advices for Hamsyl 3750iu Injection
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Pregnancy
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There are no established adverse effects of Hamsyl 3750IU Injection in pregnant women. Consult your doctor if you are pregnant or planning to get pregnant before taking this medicine.
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Breast Feeding
 ÂIt is unclear whether Hamsyl 3750IU Injection is excreted in human milk. So you should consult a doctor before taking this medication if you are a breastfeeding mother.
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Lungs
  There is no evidence to suggest that Hamsyl 3750IU Injection harms the lungs. However, as with any medication, there is a risk of side effects that could affect the respiratory system. So patients should consult their doctor if they have any pre-existing lung disease before taking this medication.
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Liver
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Hamsyl 3750IU Injection is primarily metabolized in the liver, so inform your healthcare provider if you have any liver problems or diseases. This medication may also increase liver enzymes, which can be a sign of liver damage or inflammation. Patients taking this medication require regular blood tests to monitor liver function.
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Alcohol
 ÂIt is recommended to avoid consuming alcohol while taking Hamsyl 3750IU Injection, as alcohol can increase the risk of certain side effects associated with the medication, such as stomach ulcers or gastrointestinal bleeding.
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Driving
  Patients receiving Hamsyl 3750IU Injection should be advised to avoid driving or operating machinery if they experience side effects such as fatigue, dizziness, or blurred vision, impairing a patient's ability to drive or operate machinery safely.
Side Effects of Hamsyl 3750iu Injection
Like all medications, Hamsyl 3750IU Injection can cause side effects, although not everyone who takes it will experience them. Â
Serious:
- Anaphylaxis (severe allergic reaction)
- Thrombosis (blood clots)
- Hemorrhage (bleeding)
- Tumor Lysis Syndrome (a potentially life-threatening condition due to breakdown of cancer cells)
- Acute pancreatitis (inflammation of the pancreas)
- Hepatotoxicity (liver damage or failure)
- Neurotoxicity (damage to the nervous system)
- Hypersensitivity reactions (allergic reactions, including anaphylaxis)
- Renal failure (kidney damage or failure)Â
Common:Â
- Nausea
- Vomiting
- Diarrhea
- Fatigue
- Loss of appetite
- Headache
- Fever or chills
- Muscle or joint pain
- Rash or itching
- Swelling or redness at the injection site
Word of Advice
If you are receiving treatment with Hamsyl 3750IU Injection, report any side effects or concerns promptly. If you are pregnant or planning to become pregnant or breastfeeding, it is important to discuss the risks and benefits with your healthcare provider. If patients see any sign of jaundice (yellow skin and eyes, abdominal pain, vomiting) after taking this medication, they should contact a doctor immediately because it can cause pancreas inflammation.
Patients require close monitoring for any signs of abnormal bleeding or clotting. Making lifestyle changes, such as quitting smoking, maintaining a healthy weight, and eating a healthy diet, can also help support your overall health and reduce the risk of cancer-related complications. Additionally, seeking support from family members, friends, or support groups can provide patients with emotional support and help them cope with the challenges of cancer treatment.
FAQs
Q 1. Can I take Hamsyl 3750IU Injection if I have diabetes?
Patients with diabetes may still be able to use Hamsyl 3750IU Injection, but caution is needed as the medication can cause glucose intolerance and hyperglycemia. Patients with a history of diabetes should be closely monitored for signs of high blood sugar, such as increased thirst, urination, and fatigue, during treatment.
Q 2. Can I use Hamsyl 3750IU Injection if I have kidney disease?
Patients with kidney disease may still be able to use Hamsyl 3750IU Injection, but caution is needed as the medication can cause kidney toxicity. Dosing and monitoring may need to be adjusted based on the severity of kidney disease.
Q 3. How will Hamsyl 3750IU Injection affect my blood?
Hamsyl 3750IU Injection can cause blood clotting disorders, leading to serious or life-threatening bleeding or clotting. Patients should be closely monitored for signs of abnormal bleeding or clotting.
Q 4. Can Hamsyl 3750IU Injection be given to patients with a history of pancreatitis?
It depends on the severity and cause of the pancreatitis. Patients with a history of pancreatitis may be at increased risk of experiencing pancreatitis while using Hamsyl 3750IU Injection. However, if the benefits of using this medication outweigh the risks, it may sometimes be used with careful monitoring.
Q 5. How long does the effect of Hamsyl 3750IU Injection last?
The effect of Hamsyl 3750IU Injection may last several weeks, depending on the patient's medical condition and response to treatment.
Fact Box of Hamsyl 3750iu Injection
Molecule name: Pegaspargase | Therapeutic class: Anticancer |
Pharmacological class:Â Asparagine-specific enzyme inhibitors
| Indications:Â 1. Acute Lymphoblastic Leukemia 2. Non-Hodgkin's Lymphoma |
References
- KD Tripathi, Essentials of Medical Pharmacology, Anticancer drugs, 7th edition, 2013, 868
- Goodman & Gilman’s, The Pharmacological Basis of Therapeutics, Cytotoxic agents, 12th edition, 2011, 1720
- Les Laboratories Servier, Electronic medicines compendium (EMC), [ Revised on Nov 2021] [ Accessed on 25th April 2023], https://www.medicines.org.uk/emc/files/pil.10824.pdf
- Sigma-Tau Pharmaceuticals, US Food, and Drug Administration, [ Revised on March 2011] [ Accessed on 25th April 2023], https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/103411s5126lbl.pdf
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