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Indirab Injection
Prescription Required
Salt Composition : Purified Vero Cell Rabies Vaccine
Manufacturer : BHARAT BIOTECH INTERNATIONAL LTD
Origin of Medicine : India
1 Vial(s) Of 0.5ml
Introduction to Indirab Injection
Indirab Injection is composed of a Purified Vero Cell Rabies vaccine, which is indicated to prevent and treat rabies before and after exposure to the virus. This vaccine is made by growing the rabies virus in these cells and then purifying it to remove unwanted substances. The purified virus is then inactivated, meaning it can no longer cause disease but stimulate an immune response. Pre-exposure vaccination is for travelers, those in high-risk occupations, and children living in rabies-prone areas. Post-exposure prophylaxis refers to prompt wound management and vaccination. This vaccine is prepared from the Pitman-Moore strain of the Rabies virus grown in Vero cells.
- Rabies is an acute, progressive disease caused by the rabies virus belonging to the Rhabdoviridae family. It spreads through the saliva of the infected animals after bites or scratches. Though this infection is 100% fatal, it is 100% preventable with timely measures and the correct use of available vaccines, immunoglobulins, or monoclonal antibodies. Individuals with a known hypersensitivity to the Indirab Injection or its components should not receive it. If an individual is currently experiencing a moderate to severe illness, it may be advisable to delay vaccination until they have recovered. However, a mild illness, such as a common cold, usually does not prevent receiving the vaccine.
Uses of Indirab Injection
Indirab Injection is used in the following:
- Immunization before possible exposure to rabies
- Post-exposure treatment after exposure to a suspected rabid animal
- Prevention of infection for high-risk people (veterinarians, municipal workers, medical and paramedical workers)
Therapeutic Effects of Indirab Injection
The Indirab Injection works by introducing inactivated rabies virus particles to the body. This exposure triggers an immune response, producing specific antibodies that recognize and target the rabies virus. If a vaccinated person subsequently encounters the virus, their immune system is primed to quickly recognize and neutralize it, preventing it from causing it.
Interaction of Indirab Injection with other drugs
Inform the doctor about your medicines, including prescription, over-the-counter, nutritional or vitamin supplements, and herbal products. Certain medications may interact with Indirab Injection, reducing effectiveness by causing undesirable side effects.Â
More Information about Indirab Injection
- Store in a refrigerator (2–8°C).
- Shake well before use.
- Keep away from moisture, heat, and light.
- It should not be frozen.
- Keep it in its original packaging.
- Keep away from children and pets.
How to consume Indirab Injection
The Indirab Injection is typically given as a series, with the exact schedule determined by healthcare professionals based on factors such as age, health status, and risk of exposure to rabies. The injections are usually given in the upper arm for adults and older children or in the thigh muscle for infants and young children.
Safety Advices for Indirab Injection
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Pregnancy
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The safety of the Indirab Injection during pregnancy has not been extensively studied. So Before taking it women should consult the concerned doctor if they are pregnant or think they might be pregnant
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Breast Feeding
 ÂBreastfeeding women should always consult a doctor before taking the Indirab Injection.
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Lungs
  Patients with pre-existing lung disorders should consult a doctor before taking the Indirab Injection.
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Liver
  Inform your physician before starting this treatment if you have liver disease or hepatitis infections before taking the Indirab Injection.
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Alcohol
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It is generally recommended to avoid excessive alcohol consumption while taking the Indirab Injection or any medication. Alcohol can interact with this medication and affect liver function.
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Driving
  People may experience side effects, including dizziness, drowsiness, or fatigue, while taking the Indirab Injection. In that case, avoid driving or operating heavy machinery.
Side Effects of Indirab Injection
Indirab Injection cause some side effects like all medications, although not everyone will experience them.Â
Serious:
- Anaphylactic reactions (severe allergic reaction)
Common:
- Pain
- Swelling
- Pruritus at the site of injection
- Fever
- Shivering
- Fainting
- Headache
- Dizziness
- Muscle pain
- Nausea
- Vomiting
- Stomach pain
- Dry mouth
Word of Advice
If you are considering getting Indirab Injection, you should know the potential risks and warnings associated with the vaccine. Pregnant and breastfeeding women should always consult a doctor before taking it. Inform your physician before beginning treatment if you have or ever had a mental illness, seziures, hepatitis infection, skin rashes, or any other signs of infection or inflammation. Reporting any adverse events is crucial for ongoing safety monitoring. Consulting with a healthcare professional is essential to address specific concerns and ensure appropriate vaccination decisions.
FAQs
Q 1. Is it necessary to receive a booster dose of the Indirab Injection after completing the initial series?
The need for a booster dose of the Indirab Injection can vary depending on factors such as the individual's risk of exposure to rabies and the duration since the initial vaccination series. Healthcare professionals can provide recommendations on booster doses based on the specific circumstances.
Q 2. Can the Indirab Injection be given to individuals with a weakened immune system, such as those on immunosuppressive medication?
Indirab Injection can generally be administered to individuals with a weakened immune system, but the immune response may be reduced. Healthcare professionals can evaluate the risks and benefits and adjust the vaccination schedule or recommend additional precautions for individuals with compromised immune systems.
Q 3. How long does immunity from the Indirab Injection last?
The duration of immunity provided by the Indirab Injection can vary. It is important to consult with a healthcare professional to determine the appropriate timing for booster doses or additional vaccinations based on the individual's risk factors and the specific recommendations in your region.
Q 4. Can the Indirab Injection be given to children or infants?
The Indirab Injection can be given to children and infants. The vaccination schedule may vary depending on the age and health of the child. It is best to consult a healthcare professional for guidance on the appropriate timing and dosage for pediatric vaccination.
Q 5. Can the Indirab Injection be administered to individuals with a fear or phobia of needles?
Fear of needles, known as needle phobia, is a common concern. Healthcare professionals are trained to manage and support individuals with needle phobia. Techniques such as distraction, relaxation exercises, or numbing creams can help ease anxiety during vaccine administration.
Q 6. Can the Indirab Injection be given to individuals with a history of autoimmune disorders?
The Indirab Injection is generally safe for individuals with autoimmune disorders. However, consulting with a healthcare professional who can evaluate the specific autoimmune disorder and assess any potential risks or considerations is important. They can provide personalized guidance based on the individual's medical history and current condition
Q 7. Can the Indirab Injection be given to individuals with a history of neurological disorders?
In most cases, individuals with a history of neurological disorders can receive the Indirab Injection without any issues. However, if you have specific concerns or a complex medical history, it is advisable to consult with a healthcare professional who can evaluate your situation and provide appropriate recommendations.
Fact Box of Indirab Injection
Molecule name: Purified Vero Cell Rabies vaccine | Therapeutic class: Antiviral agents |
Pharmacological class:Â Inactivated Vaccine | Indications: Rabies |
References
- Sudarshan MK. World Health Organization 2018 Guidelines on Rabies Prophylaxis: Contentious Issues. Pediatr Inf Dis 2019;1(4):154–156, https://www.pidjournal.com/doi/PID/pdf/10.5005/jp-journals-10081-1226
- Thomas Moulenat et al., Purified Vero Cell Rabies vaccine (PVRV, Verorab®): A Systematic Review of Intradermal Use Between 1985 and 2019, Trop. Med. Infect. Dis., 2020, 5, 40, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7157209/pdf/tropicalmed-05-00040.pdf
- Bharat Biotech International Ltd, [Revised on Aug 2018] [Accessed on 22nd May 2023], https://www.bharatbiotech.com/images/indirab/Indirab-Package-Insert.pdf
- AbhayRIG, [Accessed on 22nd May 2023], https://www.cphi-online.com/46/resourcefile/09/72/83/IIL%20Human%20Health%20Vaccine%20Brochure.pdf
- KD Tripathi, Vaccines, Antisera and lmmuneglobulins, Essentials of Medical Pharmacology, 8th Edition, 2019, 978-986.
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