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Irinot 100mg Injection
Prescription Required
Salt Composition : Irinotecan
Manufacturer : KHANDELWAL LABORATORIES PVT LTD
Origin of Medicine : India
1 Vial(s)
Introduction to Irinot 100mg Injection
Irinot 100mg injection belongs to the group of medications called anti-cancer medicines or cytostatics. It consists of the active ingredient Irinotecan hydrochloride trihydrate. It is indicated for advanced colon cancer and rectal cancer in adults. It is prescribed alone or in combination with other chemotherapeutic agents. Cancer in the colon and rectum is prevalent in age groups above 50 and is further triggered by genetic and environmental factors. Â
Myelosuppression (bone marrow suppression leading to low levels of RBC, WBC, and platelets in the blood) and diarrhea are this medication's most common adverse effects. Other common side effects of Irinot 100mg injection are nausea, vomiting, abdominal pain, constipation, anemia, pain, fatigue, fever, infections including sepsis, abnormal bilirubin levels, hair loss, and weight loss. Inform your doctor if these side effects disturb or persist in you. Notify your doctor if you have chronic inflammatory bowel disease or bowel obstruction or if you took any live vaccines.Â
Inform your physician if you are allergic to Irinotecan and its ingredients. Before starting treatment, let your physician know if you have liver problems or jaundice, kidney and heart problems, asthma, high blood pressure or high cholesterol, or severe diarrhea. If you are smoking or have ever received radiation therapy, report to your healthcare provider. Consult your healthcare provider if you take other medicines, herbs, and supplements. Effective contraception (birth control) by males and females during treatment is important to avoid pregnancy. Your physician will perform blood tests during and before treatment to check for the effects of Irinot 100mg injection on blood counts or blood chemistry.
Uses of Irinot 100mg Injection
- Treatment of metastatic cancer of the colon and rectum (large intestine).
Therapeutic Effects of Irinot 100mg Injection
Irinot 100mg injection works by converting its active metabolite with the help of liver enzymes and inhibits the Topoisomerase I enzyme. This causes damage to the DNA synthesis and its replication, thus preventing the cancer cells from growing and spreading.
Interaction of Irinot 100mg Injection with other drugs
Inform your doctor about any prescribed medications, over-the-counter medications, nutritional or vitamin supplements, and herbal products that you are taking or have taken before the treatment. Certain medications tend to interact with Irinot 100mg injection and can cause potential side effects.
More Information about Irinot 100mg Injection
- Do not freeze.
- Store protected from light at a temperature not exceeding 25°C.
- Keep this medicine away from the sight and reach of children.
- Always check the expiry date before consuming it.
How to consume Irinot 100mg Injection
Take this medicine exactly as prescribed. Your healthcare professional administers it into your vein. Do not self-administer. Your physician will recommend a DNA test before taking this medicine. Your physician will decide the correct dosage and duration based on age, body weight, and disease condition.
Safety Advices for Irinot 100mg Injection
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Pregnancy
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Irinot 100mg injection is unsafe during pregnancy as it may harm the developing baby. Women with potential childbearing use effective contraceptives during and after six months after treatment.Â
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Breast Feeding
 ÂIt is unsafe to use during breastfeeding as Irinot 100mg injection and its metabolites are found in human milk. It must be discontinued for the duration of therapy. Consult your doctor for advice. Â
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Lungs
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It is unknown whether Irinot 100mg injection is safe for patients with lung problems. Notify your physician if you have any lung disease before starting the treatment. Contact your doctor if you experience any lung-related symptoms.
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Liver
  Irinot 100mg injection is used with caution in patients with liver impairment. Inform your physician before starting treatment if you have liver disease or jaundice. Your physician will monitor your liver functions and adjust the dose accordingly.
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Alcohol
 ÂIt is not known whether it is safe to drink alcohol while taking Irinot 100mg injection. Check with your doctor for advice.
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Driving
  After taking this medicine, you may feel dizzy or tired for the first 24 hours. Do not use any tools or drive during treatment with Irinot 100mg injection.Â
Side Effects of Irinot 100mg Injection
.Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them.Â
Serious
- Early and late diarrhea
- Allergic reactions
- Kidney impairment
- Lung problems
- Low levels of RBC, WBC, and platelets in the bloodÂ
Common
- Nausea, vomiting, abdominal pain
- Constipation
- Diarrhea
- Anemia
- Pain
- Fatigue
- Fever, infections including sepsis
- Abnormal bilirubin levels
- Hair loss
- Weight loss
Word of Advice
This injection should be taken cautiously in patients with kidney disease or who have undergone dialysis. Diarrhea is the first sign of Irinot 100mg injection. It may be serious if diarrhea starts more than 24 hours after administration of this medication. It should be treated immediately and kept under close supervision. If left untreated, it could lead to dehydration and serious chemical imbalances, which can be life-threatening. Â
Try to avoid laxatives and stool softeners while taking Irinot 100mg injection. Drink large amounts of water and rehydration fluids immediately. Take antidiarrheal treatment like loperamide. Notify your doctor if you experience any serious side effects. Contact your doctor for more information. Do not stop the medicine until your doctor advises. Do not double-dose the medicine to make up for a forgotten dose.
FAQs
Q 1. Do you lose your hair with Irinot 100mg injection?
Hair loss can be a possible side effect of using Irinot 100mg injection. It is recommended to discuss this potential side effect with your doctor for further information and guidance.
Q 2. Does Irinot 100mg injection cause liver damage?
Irinot 100mg injection may cause liver impairment or damage. Inform your physician before starting treatment if you have liver disease or jaundice. Your doctor may adjust the dose based on your medical condition.
Q 3. What are the serious side effects of Irinot 100mg injection?
Some serious side effects of Irinot 100mg injection are early and late, diarrhea, allergic reactions, kidney impairment, lung problems, and low levels of RBC, WBC, and platelets in the blood.
Q 4. How to prevent diarrhea while taking Irinot 100mg injection?
Drink large amounts of water and rehydration fluids to prevent diarrhea. It is advised to take antidiarrheal medicines, including loperamide.
Q 5. What should I do if I miss a dose of Irinot 100mg injection?
If you miss a capsule dose, take it as soon as possible. However, if it's close to the time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose of Irinot 100mg injection.
Fact Box of Irinot 100mg Injection
Molecule name: Irinotecan | Therapeutic class: Topoisomerase I inhibitors |
Pharmacological class: Antineoplastics | Indications: Colon and rectum cancer (large intestine cancer |
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References
- Accord Healthcare Limited, Electronic Medicines Compendium (EMC), [Revised on June 2022] [Accessed on 1st June 2023], https://www.medicines.org.uk/emc/files/pil.7318.pdf
- Pharmacia & Upjohn Co, US Food & Drug Administration, [Revised on Dec 2014] [Accessed on 1st June 2023], https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/020571s048lbl.pdf
- I.D. Penman, C.W. Lees, Alimentary Tract and Pancreatic Disease, Davidson’s Principles and Practice of Medicine, 22nd Edition, 2014, 837-920.
- Edward Chu, Cancer Chemotherapy, Lange’s Basic and Clinical Pharmacology, 14th Edition, 2018, 948-976.
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