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Jollifos 50mg Tablet
Prescription Required
Salt Composition : Miltefosine
Manufacturer : JOLLY HEALTHCARE
Origin of Medicine : India
10 Tablet(s) In A Strip
Introduction to Jollifos 50mg Tablet
Jollifos 50mg tablet contains the active ingredient Miltefosine. It is an antiprotozoal medication used primarily to treat leishmaniasis, a parasitic infection caused by the Leishmania species.
Jollifos 50mg tablet is indicated for the treatment of both cutaneous and visceral leishmaniasis in adults and children. It works by inhibiting the growth and replication of the Leishmania parasites, thereby helping to eliminate the infection from the body.
Before starting treatment with Jollifos 50mg tablet, inform your doctor about any existing health conditions, particularly kidney issues or if you are pregnant or breastfeeding. It is important to disclose all medications you are currently taking, as this can help avoid possible interactions. Watch for any unusual symptoms, such as gastrointestinal disturbances, rash, or signs of liver problems, and report them to your physician promptly.
Uses of Jollifos 50mg Tablet
Jollifos 50mg tablet effectively treats leishmaniasis, a parasitic disease spread by sandflies, including the most severe form known as kala-azar (visceral leishmaniasis), which impacts internal organs. It is suitable for adults and adolescents aged 12 and older who weigh at least 30 kg (66 lbs) and is specifically indicated for visceral leishmaniasis caused by Leishmania donovani and cutaneous leishmaniasis due to Leishmania braziliensis.
Jollifos 50mg tablet is also effective against various forms of leishmaniasis, including cutaneous, visceral, and mucosal types. It also targets infections from free-living amoebas such as Naegleria fowleri and Balamuthia mandrillaris.
Therapeutic Effects of Jollifos 50mg Tablet
Jollifos 50mg tablet effectively targets Leishmania parasites through several key mechanisms. It disrupts the parasite's cell membranes by interacting with lipids, compromising their structural integrity. By inhibiting cytochrome c oxidase in the mitochondria, Jollifos 50mg tablet hampers the parasite's energy production. It also induces a form of cell death similar to apoptosis, further aiding in the elimination of the parasites. Together, these actions significantly reduce the viability of Leishmania, making Jollifos 50mg tablet is a powerful treatment option for leishmaniasis.
Interaction of Jollifos 50mg Tablet with other drugs
Before starting the Jollifos 50mg tablet, consult your doctor about all medications you are currently taking. This includes prescription drugs, over-the-counter medicines, and any supplements. Being aware of potential interactions is crucial for your safety and the effectiveness of your treatment.
More Information about Jollifos 50mg Tablet
- Store JJollifos 50mg tablet at room temperature between 20°C to 25°C.
- Keep it out of sight and reach of children and pets.
- Store it in the original container.
- Protect it from moisture, heat, and direct sunlight.
How to consume Jollifos 50mg Tablet
Take Jollifos 50mg tablet orally with food to help reduce gastrointestinal side effects. If you weigh between 30 and 44 kg, take one 50 mg capsule twice daily for 28 consecutive days. If you weigh 45 kg or more, take one 50 mg capsule three times daily for the same duration. Follow this dosing schedule closely to ensure effective treatment for leishmaniasis. Regularly check in with your doctor to monitor your response and address any potential side effects.
Safety Advices for Jollifos 50mg Tablet
Pregnancy
Avoid using Jollifos 50mg tablet during pregnancy, as it can harm the developing baby.
Breast Feeding
Do not breastfeed while taking the Jollifos 50mg tablet and for 1 week after your last dose, as the drug may pass into breast milk.
Lungs
Talk to your doctor before starting treatment with Jollifos 50mg tablet if you have any lung conditions.
Liver
Inform your doctor about any liver disorders before taking the Jollifos 50mg tablet. They may adjust your dose or delay treatment based on your liver function.
Alcohol
Consult your doctor before taking Jollifos 50mg tablet if you consume alcohol, as it is not known whether it is safe to use the medication in conjunction.
Driving
You are not likely to be affected when driving or using tools and machines while taking Jollifos 50mg tablet. However, consult your doctor before starting this medication.
Side Effects of Jollifos 50mg Tablet
Like all medications, Jollifos 50mg tablet can cause side effects, although not everyone who takes it will experience them.
Common side effects of Jollifos 50mg tablet may include:
- Nausea & Vomiting
- Diarrhea
- Abdominal pain
- Decreased appetite
- Dizziness
- Headache
- Sleepiness
- Skin itching
- Abnormalities in liver or kidney tests
Serious side effects of Jollifos 50mg tablet include:
- Fertility problems
- Testicular pain and absent or decreased ejaculation
- Kidney and liver problems
- Serious skin problems (e.g., Stevens-Johnson Syndrome)
- Decrease in platelets
Word of Advice
Inform your doctor if you have a history of kidney or liver issues, as they may need to monitor you closely during treatment. Regularly check for any gastrointestinal symptoms and stay hydrated to prevent dehydration. Report any skin reactions or symptoms of low blood cell counts to your healthcare provider immediately. Always disclose all medications you are taking to avoid potential interactions. Use Jollifos 50mg tablet during pregnancy only when necessary, and monitor for any allergic reactions; report any concerns promptly.
FAQs
Q 1. Is Jollifos 50mg Tablet an antibiotic?
Jollifos 50mg Tablet is not an antibiotic. It’s an antiparasitic medication used mainly to treat leishmaniasis, a disease caused by the Leishmania parasites. It works by disrupting the growth and survival of these parasites, which is different from how antibiotics target bacteria.
Q 2. Is Jollifos 50mg tablet available in India?
Yes, you can find Jollifos 50mg tablets in India. It is commonly used to treat leishmaniasis, including visceral leishmaniasis. However, availability may vary by region and healthcare facilities. Consult your healthcare provider or check with a local pharmacy for more information on its availability.
Q 3. What is the success rate of Jollifos 50mg tablet?
Jollifos 50mg tablet shows high success rates in treating visceral leishmaniasis, with cure rates of 94% to 97% in clinical trials conducted in India. In children under 12, the cure rates range from 83% to 94%. A trial in Bangladesh achieved an 85% cure rate with the standard regimen.
Q 4. What is the duration of treatment with Jollifos 50mg tablet?
The typical duration of treatment with Jollifos 50mg tablet is 28 days. While the dosage may vary based on age or weight, the treatment duration generally remains the same.
Q 5. What class of drug is Jollifos 50mg tablet?
Jollifos 50mg tablet is an antileishmanial drug that treats leishmaniasis, including visceral and cutaneous forms of the disease.
Fact Box of Jollifos 50mg Tablet
Molecule name | Miltefosine |
Pharmacological class | Antileishmanial drug |
Therapeutic class | Antiprotozoal agent |
Indications | Treatment of leishmaniasis, including visceral leishmaniasis caused by Leishmania donovani and cutaneous leishmaniasis due to Leishmania braziliensis. |
References
- Efficacy and Tolerability of Miltefosine in the Treatment of Cutaneous Leishmaniasis - PMC (nih.gov)
- https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/204684s000lbl.pdf
- https://ncvbdc.mohfw.gov.in/WriteReadData/l892s/Guidelines_on_miltefosine.pdf
- https://pubmed.ncbi.nlm.nih.gov/10588964/https://pubmed.ncbi.nlm.nih.gov/10588964/
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