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Kerendia 20mg Tablet
Prescription Required
Salt Composition : Finerenone
Manufacturer : BAYER ZYDUS PHARMA PVT LTD
Origin of Medicine : Germany
14 Tablet(s) In Astrip
Introduction to Kerendia 20mg Tablet
Kerendia 20mg Tablet is a medication containing an active component called Finerenone. It falls under the category of nonsteroidal mineralocorticoid receptor antagonists (MRAs). Its purpose is to address conditions associated with imbalanced levels of mineralocorticoid hormones, specifically aldosterone, within the body. The primary usage of this medication is for the treatment of chronic kidney disease (CKD) in individuals diagnosed with type 2 diabetes. It aids in lowering the likelihood of kidney disease advancement and also mitigates the risk of cardiovascular incidents, such as heart failure, in these patients.Â
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Kerendia 20mg Tablet should not be used in individuals with known hypersensitivity or allergy to the drug or its components. It can increase the potassium levels in the blood. It should be used cautiously or avoided in patients with hyperkalemia or those already taking medications that can increase potassium levels (such as potassium-sparing diuretics or potassium supplements). This medication can affect the balance of electrolytes in the body. Monitoring potassium, sodium, and other electrolyte levels may be necessary during treatment. Kerendia 20mg Tablet may affect blood glucose levels, especially in patients with diabetes. If a person is undergoing surgery, it is important to inform the healthcare team about using Kerendia 20mg Tablet, as it may need to be temporarily discontinued before the procedure.
Uses of Kerendia 20mg Tablet
- Chronic kidney disease (CKD) with type 2 diabetes
Therapeutic Effects of Kerendia 20mg Tablet
Kerendia 20mg Tablet is a selective nonsteroidal mineralocorticoid receptor antagonist (MRA) that blocks the effects of aldosterone, a hormone involved in fluid balance and blood pressure regulation. Inhibiting mineralocorticoid receptors reduces sodium and water retention, prevents potassium excretion, and provides therapeutic benefits in chronic kidney disease, including slowing disease progression, reducing cardiovascular risk, and controlling blood pressure.
Interaction of Kerendia 20mg Tablet with other drugs
Inform your healthcare provider about all the medicines you take, including prescription medications, over-the-counter medications, nutritional and vitamin supplements, and herbal products. Certain medications interact with Kerendia 20mg Tablet and reduce their effectiveness by causing undesirable side effects.Â
More Information about Kerendia 20mg Tablet
- Store at controlled room temperature, between 20°C to 25°C (68°F to 77°F).
- Protect the medicine from light and excessive moisture.
- Keep the medicine out of reach of children and pets
- Take only a partial dose to compensate for a forgotten dose.
How to consume Kerendia 20mg Tablet
To use Kerendia 20mg Tablet, follow the prescribed dosage and instructions provided by your healthcare provider. Take the medications as directed, usually orally, with or without food. Do not skip doses or stop taking them without consulting your healthcare provider. Consult your healthcare provider or pharmacist for guidance if you have any questions or concerns.
Safety Advices for Kerendia 20mg Tablet
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Pregnancy
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Kerendia 20mg Tablet may cause harm to an unborn baby. Inform your doctor if you are pregnant or planning to get pregnant before taking it. The doctor will explain the potential risks and benefits.
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Breast Feeding
 ÂBreastfeeding is not recommended along with the treatment of Kerendia 20mg Tablet.
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Lungs
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It is important to discuss your specific lung condition with your healthcare provider, as they can provide personalized advice based on your medical history and individual needs.
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Liver
  Kerendia 20mg Tablet is contraindicated for severe liver impairment. Prior liver conditions or concerns should be communicated to the healthcare provider before starting it. For mild to moderate liver impairment, caution with potential dose adjustments and regular liver function monitoring is advised.
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Alcohol
 ÂIt is unsafe to drink alcohol while taking Kerendia 20mg Tablet. It may reduce the drug's effectiveness and can cause toxic side effects.Â
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Driving
  Kerendia 20mg Tablet can cause dizziness. It is recommended to avoid driving and operating heavy machinery during the treatment.Â
Side Effects of Kerendia 20mg Tablet
Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them.Â
Serious
- Severe allergic reactions (e.g., rash, itching, swelling, severe dizziness, difficulty breathing)
- Worsening of kidney function or acute kidney injury
- Liver problems (e.g., jaundice, dark urine, abdominal pain)
- Severe hyperkalemia (symptoms can include muscle weakness, irregular heartbeat, and palpitations)
- Hypotension leading to fainting or loss of consciousness
Common
- Hyperkalemia (high levels of potassium in the blood)
- Diarrhea
- Dizziness
- Fatigue
- Headache
- Nausea
- Hypotension (low blood pressure)
Word of Advice
To ensure proper usage of Kerendia 20mg Tablet, adhere to the recommended dosage and follow the instructions provided. If you are currently pregnant, planning a pregnancy, or breastfeeding, it is crucial to consult your healthcare provider about this medication's potential risks and benefits. Generally, the use of this medicine is not recommended during pregnancy and breastfeeding. Unless advised otherwise by your healthcare provider, it is advisable to restrict the intake of high-potassium foods like bananas, oranges, tomatoes, and salt substitutes. Some individuals may experience changes in mood or symptoms of depression while taking this medication. The use of this medication in both elderly individuals and children requires special consideration. Adherence and open communication ensure the safe use of this medication.
FAQs
Q 1. Can Kerendia 20mg Tablet be used in patients with both heart failure and kidney disease?
Kerendia 20mg Tablet is specifically indicated for treating heart failure with reduced ejection fraction (HFrEF) in patients with chronic kidney disease (CKD) and type 2 diabetes. It has been shown to provide cardiovascular and renal benefits in this population.
Q 2. Can Kerendia 20mg Tablet be used in patients with a history of adrenal gland problems?
Kerendia 20mg Tablet should be used with caution in patients with adrenal gland problems or adrenal insufficiency. Close monitoring may be required, and your healthcare provider will evaluate the potential risks and benefits before prescribing this medication in such cases.
Q 3. Can Kerendia 20mg Tablet be used in children and adolescents?
The safety and efficacy of Kerendia 20mg Tablet in children and adolescents have not been established. It is primarily indicated for use in adults, and its use in the pediatric population is not recommended.
Q 4. Can Kerendia 20mg Tablet cause low blood pressure (hypotension)?
The potential side effect of Kerendia 20mg Tablet is low blood pressure, particularly when initiating the medication or increasing the dosage. It is important to inform your healthcare provider if you encounter symptoms such as dizziness, lightheadedness, or fainting. They will assess the situation and may need to adjust your dose or consider additional interventions if required.
Q 5. Can Kerendia 20mg Tablet affect hormone levels in the body?
Yes, Kerendia 20mg Tablet can affect hormone levels, particularly those related to the renin-angiotensin-aldosterone system. Your healthcare provider will monitor hormone levels during treatment to ensure they remain within a safe range.
Q 6. Can Kerendia 20mg Tablet be used in patients with a history of electrolyte imbalances?
Patients with a history of electrolyte imbalances should use Kerendia 20mg Tablet with caution. Regular monitoring of electrolyte levels, particularly potassium, is essential. Your healthcare provider may recommend dietary modifications or prescribe additional medications to help maintain electrolyte balance.
Fact Box of Kerendia 20mg Tablet
Molecule name: Finerenone  | Therapeutic class: Mineralocorticoid receptor antagonists |
| Pharmacological class: Non-steroidal Mineralocorticoid receptor antagonists (MRAs) | Indications:Â Chronic kidney disease (CKD) with type 2 diabetes |
References
- Glenmark Pharmaceuticals Europe Limited, Electronic Medicines Compendium, [Revised on Feb 2021] [Accessed on 27th May 2023], https://www.medicines.org.uk/emc/files/pil.9939.pdf
- 2. Edward Chu, Cancer Chemotherapy, Lange’s Basic and Clinical Pharmacology, 14th Edition, 2018, 948-976.
Disclaimer
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