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Larinate 200 Kit Tablet
Prescription Required
Salt Composition : Artesunate,sulphadoxine,pyrimethamine
Manufacturer : IPCA LABORATORIES LTD
Origin of Medicine : India
6 Tablet(s) In A Strip
Introduction to Larinate 200 Kit Tablet
Larinate 200 Kit Tablet contains the active ingredients Artesunate, Sulphadoxine, and Pyrimethamine. It is an antimalarial medication used to treat uncomplicated malaria caused by Plasmodium falciparum. This combination works effectively in areas with high resistance to other antimalarial drugs, overcoming resistance and improving treatment outcomes.
Larinate 200 Kit Tablet works by targeting different stages of the malaria parasite’s lifecycle. Artesunate generates reactive oxygen species that damage the parasite’s cell membranes. Sulphadoxine inhibits folate synthesis, while Pyrimethamine blocks another enzyme crucial to the parasite’s DNA production. This multi-target approach makes it more effective than single-drug treatments.
Larinate 200 Kit Tablet is used to treat uncomplicated Plasmodium falciparum malaria. Do not use it if you are allergic to any of the components, or if you have liver, kidney, or blood disorders, or if you are pregnant or breastfeeding. Inform your doctor about any history of G6PD deficiency, as this may increase the risk of haemolysis.
Common side effects include nausea, vomiting, headache, dizziness, and fatigue. Serious side effects may include severe allergic reactions, liver damage, and blood disorders. If you experience difficulty breathing, persistent fever, severe rash, or unusual bruising or bleeding, seek medical help immediately. Always follow your healthcare provider’s instructions for dosage and proper use.
Uses of Larinate 200 Kit Tablet
The uses of the Larinate 200 Kit Tablet are:
- Treatment of uncomplicated malaria caused by Plasmodium falciparum.
- Helps overcome drug resistance in malaria infections.
- Effective in areas with high resistance to other antimalarial medications.
Therapeutic Effects of Larinate 200 Kit Tablet
The Larinate 200 Kit Tablet works to treat malaria. Artesunate generates reactive oxygen species that damage the parasite’s membranes. Sulphadoxine blocks dihydropteroate synthetase, inhibiting folate synthesis, while Pyrimethamine targets dihydrofolate reductase, disrupting the parasite’s DNA production. By interfering with these critical metabolic pathways, the combination effectively kills the malaria parasite.
Interaction of Larinate 200 Kit Tablet with other drugs
It is important to inform your healthcare professional about all the medications you are taking, including prescription drugs, over-the-counter medications, nutritional supplements, and herbal products. Some medications may interact with Artesunate, Sulphadoxine, and Pyrimethamine, potentially affecting their effectiveness or causing side effects.
More Information about Larinate 200 Kit Tablet
- Keep out of reach of children and pets.
- Store in the original packaging to protect from moisture.
- Avoid direct sunlight
- Store Larinate 200 Kit Tablet at room temperature.
How to consume Larinate 200 Kit Tablet
The Larinate 200 Kit Tablet contains three antimalarial medicines: Artesunate, Sulphadoxine, and Pyrimethamine. This combination is used to treat malaria, especially in areas with resistant strains. For the correct dose and duration, consult a healthcare professional, as it depends on individual factors like the severity of infection and patient condition.
Safety Advices for Larinate 200 Kit Tablet
Pregnancy
It is unknown if Larinate 200 Kit Tablet are safe to take during pregnancy. Please consult your healthcare provider if you have any concerns.
Breast Feeding
It is unknown if Larinate 200 Kit Tablet are safe to take during breastfeeding. Please consult your healthcare provider if you have any concerns.
Lungs
If you have any pre-existing lung conditions, discuss them with your doctor before starting treatment with Larinate 200 Kit Tablet.
Liver
If you have any pre-existing lung conditions, discuss them with your doctor before starting treatment with Larinate 200 Kit Tablet.
Alcohol
It is unsafe to take alcohol while on treatment with Larinate 200 Kit Tablet.
Driving
Larinate 200 Kit Tablet may cause drowsiness and affect your ability to drive. So, it is unsafe to drive while on treatment with Larinate 200 Kit Tablet.
Side Effects of Larinate 200 Kit Tablet
Side effects are unwanted symptoms caused by medicines. Although all drugs can cause side effects, not everyone experiences them.
Common side effects of Larinate 200 Kit Tablet are
- Diarrhoea
- Headache
- Rash
- Dizziness
- Nausea
- Vomiting
- Abdominal pain
- Fatigue
Serious side effects of Larinate 200 Kit Tablet are:
- Skin reactions (e.g., blistering, peeling)
- Blood disorders (e.g., low blood cell counts, anaemia)
- Seizures or convulsions
- Liver damage (elevated liver enzymes)
- Heart problems (e.g., abnormal heart rhythms)
- Severe allergic reactions (e.g., swelling, difficulty breathing)
Word of Advice
Always follow the prescribed dosage and complete the full course of treatment with Larinate 200 Kit Tablet. Use caution if you have liver or kidney issues, blood disorders, or G6PD deficiency, and consult your healthcare provider if pregnant or breastfeeding. Monitor for side effects and seek immediate medical attention if severe allergic reactions or other serious issues occur. Always consult your doctor before starting the medication, especially if you have underlying health conditions.
FAQs
Q 1. What are the uses of the Larinate 200 Kit Tablet?
The Larinate 200 Kit Tablet is used to treat uncomplicated malaria caused by Plasmodium falciparum. It effectively addresses malaria in areas with high resistance to other antimalarial drugs. The combination targets different stages of the parasite’s lifecycle, enhancing its effectiveness.
Q 2. What is the best time to take the Larinate 200 Kit Tablet?
The best time to take the Larinate 200 Kit Tablet is typically in the morning with or without food. It is usually given as a single dose or a follow-up dose as directed by your healthcare provider. Always follow the specific instructions provided by your doctor or pharmacist to ensure effectiveness.
Q 3. Who should avoid Larinate 200 Kit Tablet?
People who should avoid the Larinate 200 Kit Tablet include those with a history of severe allergic reactions to any of the components, liver or kidney disease, blood disorders (such as anaemia or low white blood cell count), and G6PD deficiency. Pregnant or breastfeeding women should also avoid it unless prescribed by a healthcare provider after careful consideration of risks and benefits.
Q 4. How long do you take Larinate 200 Kit Tablet?
You typically take the Larinate 200 Kit Tablet as a single dose for uncomplicated malaria. In some cases, a follow-up dose may be prescribed after a few hours. Always follow the prescribed treatment duration as directed by your healthcare provider.
Fact Box of Larinate 200 Kit Tablet
| Molecule name: Artesunate, Sulphadoxine, and Pyrimethamine | Therapeutic class: Antimalarial medication |
| Pharmacological class: Combination Antimalarial Therapy | Indications: 1. Treats uncomplicated malaria caused by Plasmodium falciparum 2. Overcomes drug resistance 3. Effective in resistant areas |
References
1. Elamin SB, Malik EM, Abdelgadir T, Khamiss AH, Mohammed MM, Ahmed ES, Adam I. Artesunate plus sulfadoxine-pyrimethamine for treatment of uncomplicated Plasmodium falciparum malaria in Sudan. https://pmc.ncbi.nlm.nih.gov/articles/PMC1242247/
2. Ruwizhi N, Maseko RB, Aderibigbe BA. Recent Advances in the Therapeutic Efficacy of Artesunate. Pharmaceutics. https://pmc.ncbi.nlm.nih.gov/articles/PMC8951414/
3. Bell DJ, Nyirongo SK, Mukaka M, Zijlstra EE, Plowe CV, Molyneux ME, Ward SA, Winstanley PA. Sulfadoxine-pyrimethamine-based combinations for malaria: a randomised blinded trial to compare efficacy, safety and selection of resistance in Malawi. https://pmc.ncbi.nlm.nih.gov/articles/PMC2229666/
function in the central nervous system. https://pubmed.ncbi.nlm.nih.gov/16806306/
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