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Metbleo 15IU Injection
Prescription Required
Salt Composition : Bleomycin
Manufacturer : METTA LIFE SCIENCES PVT LTD
Origin of Medicine : India
1 Vial(s)
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Introduction to Metbleo 15iu Injection
Bleocel 15IU Injection consists of the active ingredient Bleomycin. It belongs to a group of drugs known as antineoplastic antibiotics. It is commonly used in cancer treatment to slow or stop the growth of cancer cells. It treats lymph node cancers (Hodgkin’s and non-Hodgkin’s lymphoma), head and neck cancer, and cancer in external genitalia. It either be used alone or with radiotherapy and chemotherapy treatment. This injection is also beneficial to prevent and treat the fluid accumulation in the lungs due to cancer. It works by interfering with the production of DNA and RNA in cancer cells. It can cause breaks in the DNA strands and prevent cancer cells from dividing and growing.Â
Bleocel 15IU injection can have side effects, including lung problems, skin reactions, fever, and nausea. In some cases, it can also affect the kidneys, liver, and heart. Patients receiving it, need to be closely monitored for these side effects. It is typically administered through injection or infusion, either alone or in combination with other chemotherapy drugs. The dosage and frequency of treatment depend on several factors, including the type and stage of cancer, the patient's age and overall health, and the specific treatment plan developed by the oncologist.
Uses of Metbleo 15iu Injection
- Hodgkin's lymphoma
- Non-Hodgkin's lymphoma
- Testicular cancer
- Some types of lung cancer
Therapeutic Effects of Metbleo 15iu Injection
The therapeutic effect of Metbleo 15IU Injection is inhibiting cancer cell growth and proliferation. By interfering with DNA replication and transcription, it can slow or stop the growth of cancer cells, leading to their destruction. This effect is particularly important in the treatment of Hodgkin's lymphoma, non-Hodgkin's lymphoma, testicular cancer, and some types of lung cancer, where rapid cell growth and division are characteristic features of the disease. Overall, this medication can help to shrink tumours and improve symptoms in cancer patients.
Interaction of Metbleo 15iu Injection with other drugs
Inform your healthcare provider about all your medicines, including prescription, over-the-counter, nutritional or vitamin supplements, and herbal products. Certain medications may interact with Metbleo 15IU Injection and reduce effectiveness by causing undesirable side effects.
More Information about Metbleo 15iu Injection
- Metbleo 15IU Injection should be stored according to the manufacturer's instructions or as directed by a healthcare provider.
- In general, the medication should be stored at room temperature, between 20°C and 25°C (68°F and 77°F), in a dry place, away from light and moisture.
- It should be kept in its original packaging until ready to use.
- It should be stored out of the reach of children and pets.
- Unused or expired medication should be properly disposed of in accordance with local regulations or guidelines.
How to consume Metbleo 15iu Injection
Metbleo 15IU Injection is administered through injection by a healthcare provider in a hospital or clinical setting. The dosage and frequency of administration will vary depending on the type of cancer being treated, the patient's age and weight, and other factors. It should not be taken orally, as it is not absorbed well through the gastrointestinal tract and may cause serious side effects if ingested.
During treatment, patients should follow their healthcare provider's instructions closely and attend all scheduled appointments for monitoring of their condition and response to treatment. If a dose of the drug is missed, patients should contact their healthcare provider immediately for instructions on when to take the next dose. It is important not to double the dose to make up for a missed one.
Safety Advices for Metbleo 15iu Injection
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Pregnancy
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Metbleo 15IU Injection is not safe for pregnant women as it may cause foetal harm. So it is not recommended to take this during pregnancy.
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Breast Feeding
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It is not known weather it is excreted in human milk or not. So if you are nursing an infant then it is better to consult a doctor before taking this medication.
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Lungs
  Metbleo 15IU Injection should be used with caution in patients with pre-existing lung disease or a history of lung surgery. It can cause lung toxicity, including interstitial pneumonitis and pulmonary fibrosis, which can be life-threatening. Patients with pre-existing lung disease, such as chronic obstructive pulmonary disease (COPD) or asthma, may be at higher risk of developing lung toxicity. Patients taking it should be closely monitored for signs of lung toxicity, including shortness of breath, cough, fever, and chest pain.
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Liver
  Regular monitoring of liver function tests is recommended because Metbleo 15IU Injection has been associated with liver injury in some patients. It is important to monitor liver function regularly in patients taking it, particularly in those with pre-existing liver disease or a history of liver problems.
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Alcohol
 ÂIt is generally recommended that patients taking Metbleo 15IU Injection avoid or limit their alcohol intake, as alcohol can increase the risk of liver damage and exacerbate any liver-related side effects.
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Driving
  Metbleo 15IU Injection may cause side effects such as fatigue, dizziness, or blurred vision that can impair a patient's ability to drive or operate machinery safely. If a patient experiences any side effects that affect their ability to drive or operate machinery safely while taking, they should avoid these activities and seek medical advice.
Side Effects of Metbleo 15iu Injection
Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them.
Serious
- Fever
- Chills
- Fatigue
- Loss of appetite
- Nausea and vomiting
- Mouth sores
- Skin rash or itching
- Hair loss
- Cough or shortness of breath,
- Low blood cell counts,
SeriousÂ
- Interstitial pneumonitis (inflammation of lung linings)
- Pulmonary fibrosis
- Liver toxicity
- Kidney toxicity
- Allergic reactions
- Increased risk of infections
Word of Advice
Following your healthcare provider's instructions is important if you have been prescribed Bleocel 15IU Injection. Take the medication as prescribed and promptly report any side effects or symptoms to your healthcare provider. Take steps to maintain your overall health, such as eating a balanced diet, getting enough rest, and exercising regularly, as these can help support your body's ability to tolerate medication and recover from treatment. To ensure the safest and most effective treatment, following all safety advisories related to this injection is important. Women of childbearing age should use effective birth control during treatment and afterward, as this medication can harm a developing fetus. Patients with liver or kidney disease may also require lower doses or more frequent monitoring during treatment. Patients should avoid alcohol while taking it, as it can increase the risk of liver toxicity and other side effects. Communicate openly with your healthcare provider about any concerns or questions about your treatment. If you experience serious side effects or medical emergencies, seek medical attention immediately. With careful monitoring and communication, your healthcare provider can help you navigate any challenges or concerns during treatment.
FAQs
Q 1. Can Metbleo 15IU Injection cause hair loss?
Yes, Metbleo 15IU Injection can cause hair loss, although it is not a common side effect. Hair loss typically occurs only in the area where the drug is administered (for example, in the case of intravenous infusion, hair loss may occur only on the scalp). Hair loss is usually temporary, and hair will grow back once treatment is completed.
Q 2. Can Metbleo 15IU Injection be given to children?
Yes, Metbleo 15IU Injection can be given to children, but the dose and administration frequency may differ from adults. it is used to treat several types of cancers in children, including Hodgkin's lymphoma and germ cell tumors.
Q 3. Can Metbleo 15IU Injection be used alone to treat cancer?
Metbleo 15IU Injection is rarely used alone to treat cancer. It is typically used in combination with other chemotherapy drugs or radiation therapy as part of a comprehensive treatment plan. The specific treatment plan will depend on the type and stage of cancer being treated.
Q 4. Can Metbleo 15IU Injection cause fertility problems?
Yes, Metbleo 15IU Injection can cause fertility problems in both men and women. Men may experience decreased sperm count and quality, while women may experience irregular menstrual cycles or early menopause.
Q 5. Can Metbleo 15IU Injection cause skin reactions?
Yes, Metbleo 15IU Injection can cause skin reactions such as rash or redness at the injection site. In rare cases, it may also cause more severe skin reactions such as Stevens-Johnson syndrome or toxic epidermal necrolysis. Patients should monitor their skin closely while receiving and report any unusual or severe reactions to their healthcare provider.
Q 6. Can Metbleo 15IU Injection be given at home?
A healthcare professional typically administers Metbleo 15IU Injection in a hospital or clinic setting. However, in some cases, it may be possible for patients to receive this at home through a home health agency.
Q 7. Can Metbleo 15IU Injection cause hearing loss?
Yes, Metbleo 15IU Injection can cause hearing loss as a side effect, particularly in patients who receive high doses or long-term treatment. Patients receiving should be monitored for signs of hearing loss, such as ringing in the ears, difficulty hearing, or hearing loss.
Q 8. How does the body metabolize Metbleo 15IU Injection?
Metbleo 15IU Injection is primarily metabolized by the liver and excreted through the kidneys. Patients with liver or kidney problems may be at increased risk of side effects and should be closely monitored during treatment.
Q 9. Can Metbleo 15IU Injection be given to patients with kidney problems?
Metbleo 15IU Injection is primarily excreted through the kidneys, so patients with kidney problems may be at increased risk of side effects from the drug. However, the dose may be adjusted in patients with kidney problems to reduce this risk.
Fact Box of Metbleo 15iu Injection
Molecule name: Bleomycin | Therapeutic class: Anticancer |
Pharmacological class: Antineoplastic | Indications:Â 1. Hodgkin's lymphoma 2. Non-Hodgkin's lymphoma 3. Testicular cancer 4. Some types of lung cancer |
References
- Nippon Kayaku Co., Ltd., US Food and Drug Administration, [Revised on April 2010], [Accessed on 1st Apr 2023], https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/050443s036lbl.pdf
- Edward Chu, Cancer Chemotherapy, Lange’s Basic and Clinical Pharmacology, 14th Edition, 2018, 948-976
- Accord Healthcare Limited, Electronic Medicines Compendium(EMC), [Revised on Mar 2018] [Accessed on 1st Apr 2023], https://www.medicines.org.uk/emc/files/pil.9333.pdf
- DeVita, Hellman, and Rosenberg's Cancer: Principles and Practice of Oncology, 11th edition. Lippincott Williams & Wilkins, 2019, 573-582.
- Goodman & Gilman's The Pharmacological Basis of Therapeutics, 13th Edition. McGraw Hill Education, 2017, 1317-1322
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