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Mettaparin H 25000IU Injection
Prescription Required
Salt Composition : Heparin
Manufacturer : METTA LIFE SCIENCES PVT LTD
Origin of Medicine : India
1 Vial(s)
Introduction to Mettaparin H 25000iu Injection
Mettaparin H 25000IU Injection contains an active component called Heparin. It is a widely used anticoagulant medication, meaning it prevents the formation of blood clots. It is commonly prescribed in various medical situations to reduce the risk of clotting, especially in patients who are at higher risk for developing blood clots. Mettaparin H 25000IU Injection is commonly used in hospitals to prevent and treat deep vein thrombosis (DVT), pulmonary embolism (PE), and other conditions where the formation of blood clots is a concern.
It is also used during certain surgical procedures and in dialysis to prevent clotting in the extracorporeal circuit. The effect varies among individuals, so its administration requires careful monitoring of blood clotting parameters, usually through the activated partial thromboplastin time (aPTT) test. The dosage may need to be adjusted to maintain therapeutic levels. In case of excessive bleeding or an overdose of Mettaparin H 25000IU Injection, its effects can be reversed using protamine sulfate, an antidote for heparin.
Patients with known hypersensitivity or allergic reactions should not use Mettaparin H 25000IU Injection. While this medication is generally safe, it may not suit people with certain medical conditions, such as bleeding disorders or recent major surgeries. You must inform your healthcare provider about any existing medical conditions and medications you are taking before starting the therapy. Elderly individuals may be more susceptible to bleeding complications, and lower dosages or closer monitoring may be necessary. Impaired liver or kidney function can affect the metabolism and elimination of this medication, potentially leading to adverse effects. Dosing adjustments may be necessary for patients with these conditions.
Uses of Mettaparin H 25000iu Injection
Mettaparin H 25000IU Injection is used to treat the following:
- Deep vein thrombosis
- Pulmonary embolism
- Disseminated intravascular coagulation
- Venous thromboembolism prophylaxis
- Atrial fibrillation with a high risk of stroke
- Hemodialysis
- Pregnancy-related thrombosis
Therapeutic Effects of Mettaparin H 25000iu Injection
Heparin enhances the activity of antithrombin III, a natural anticoagulant protein in the body. By binding to antithrombin III, this medication accelerates its inhibitory effect on clotting factors, particularly thrombin and factor Xa. This inhibition disrupts the blood coagulation cascade, preventing fibrin formation, an essential component of blood clots. As a result, this medication effectively reduces the risk of clot formation and growth, making it a valuable anticoagulant used in various medical conditions.
Interaction of Mettaparin H 25000iu Injection with other drugs
Inform the doctor about your medicines, including prescription, over-the-counter, nutritional or vitamin supplements, and herbal products. Certain medications may interact with Mettaparin H 25000IU Injection, reducing effectiveness by causing undesirable side effects.
More Information about Mettaparin H 25000iu Injection
- Store at room temperature, between 20°C to 25°C (68°F to 77°F).
- Keep away from moisture, heat, and light.
- It should not be frozen.
- Keep away from children and pets.
How to consume Mettaparin H 25000iu Injection
Mettaparin H 25000IU Injection is typically administered either intravenously (IV) or subcutaneously (under the skin). The specific dosage and administration method depends on the medical condition being treated, the patient's weight, age, and other factors, which a healthcare professional should determine. For IV use, this medication is usually given in a hospital setting under continuous monitoring to adjust the dosage as needed. Subcutaneous injections are often used for prophylactic purposes or in outpatient settings.
Safety Advices for Mettaparin H 25000iu Injection
Pregnancy
Mettaparin H 25000IU Injection is generally considered safe to use during pregnancy, and it is often preferred over certain other anticoagulants, especially vitamin K antagonists like warfarin. This preference is due to its minimal placental transfer, which means it does not cross the placenta to a significant extent and has a lower risk of harming the developing fetus.
Breast Feeding
While Mettaparin H 25000IU Injection is considered safe during breastfeeding, as with any medication, nursing mothers need to discuss their specific situation with a healthcare provider.
Lungs
Mettaparin H 25000IU Injection itself is generally safe for the lungs, as it is an anticoagulant primarily used to prevent and treat blood clots in the circulatory system, not the lungs directly. In fact, it is often used to treat conditions like pulmonary embolism (PE), where blood clots block blood flow to the lungs.
Liver
Mettaparin H 25000IU Injection is considered relatively safe for use in patients with liver impairment. Unlike other anticoagulant medications, this medication is not metabolised by the liver, and its elimination primarily occurs through the kidneys.
Alcohol
Mettaparin H 25000IU Injection may affected by alcohol consumption. It's essential to consult with a healthcare professional about the suitability of alcohol consumption based on individual health conditions and the specific regimen.
Driving
Mettaparin H 25000IU Injection does not directly affect a person's driving ability, as it is not known to cause drowsiness or impair cognitive and motor skills. Therefore, taking it, as prescribed will not likely interfere with one's ability to drive safely.
Side Effects of Mettaparin H 25000iu Injection
Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them.
Serious side effects of Mettaparin H 25000IU Injection are:
- Severe allergic reactions, including rash, itching, swelling, severe dizziness, or difficulty breathing
- Bleeding
- Heparin-induced thrombocytopenia (HIT)
- Osteoporosis (bone weakness)
Common side effects of Mettaparin H 25000IU Injection are:
- Bruising
- Hematomas
- Pain at the Injection Site
- Redness at the Injection Site
- Elevated Liver Enzymes
- Fever
- Nausea
- Vomiting
Word of Advice
Patients should inform their healthcare providers about their medical history, including any bleeding disorders, liver or kidney problems, recent surgeries, and allergies, to determine the appropriate dosage and administration method. Regular monitoring of blood clotting parameters, such as activated partial thromboplastin time (aPTT) or anti-Xa assay, is crucial to maintain the desired anticoagulant effect and prevent bleeding or thrombosis.
Patients should follow the prescribed dosage and administration instructions precisely and report any unusual bleeding, bruising, or allergic reactions promptly. It is advisable to avoid activities or medications that may increase the risk of bleeding while on heparin. By adhering to these instructions and maintaining open communication with healthcare providers, patients can minimise risks and maximise the benefits of this therapy.
FAQs
Q 1. What are the side effects of Mettaparin H 25000IU Injection?
Common side effects of Mettaparin H 25000IU Injection may include bruising, hematomas, pain at the injection site, and elevated liver enzymes. Serious side effects can include bleeding, heparin-induced thrombocytopenia (HIT), hypersensitivity reactions, and osteoporosis.
Q 2. Can Mettaparin H 25000IU Injection be used in children and the elderly?
Mettaparin H 25000IU Injection can be used in children and the elderly. However, special consideration is required in these populations due to differences in dosing and potential age-related factors that may affect its use.
Q 3. Is there a risk of bleeding with Mettaparin H 25000IU Injection?
Yes, Mettaparin H 25000IU Injection increases the risk of bleeding. Patients should be closely monitored for signs of bleeding and inform their healthcare provider promptly if they experience any unusual bleeding or bruising.
Q 4. How is the Mettaparin H 25000IU Injection dosed?
Mettaparin H 25000IU Injection dosing varies based on the patient's weight, medical condition, and desired anticoagulant effect. The dosage is usually adjusted based on regular monitoring of blood clotting parameters, such as activated partial thromboplastin time (aPTT) or anti-Xa assay.
Q 5. Can I take Mettaparin H 25000IU Injection if I am pregnant or breastfeeding?
Mettaparin H 25000IU Injection is generally considered safe during pregnancy and breastfeeding. It does not cross the placenta significantly and is not expected to harm the baby when used appropriately. However, its use should be under the guidance of a healthcare provider.
Fact Box of Mettaparin H 25000iu Injection
Molecule name: Heparin | Therapeutic class: Anticoagulants |
Pharmacological class: Anticoagulants
| Indications: 1. Deep vein thrombosis 2. Pulmonary embolism 3. Disseminated intravascular coagulation 4. Venous thromboembolism prophylaxis 5. Atrial fibrillation with a high risk of stroke 6. Hemodialysis 7. Pregnancy-related thrombosis |
References
- Wockhardt UK Ltd, Electronic medicines compendium (EMC), [Revised on June 2018] [ Accessed on 30th July 2023], https://www.medicines.org.uk/emc/files/pil.1678.pdf
- Baxter Healthcare Corporation, US Food, and Drug Administration, [Accessed on 30th July 2023], https://www.accessdata.fda.gov/drugsatfda_docs/label/2006/017037s158lbl.pdf
- KD Tripathi, Essentials of Medical Pharmacology, Drugs affecting coagulation, bleeding, and thrombosis, 7th edition, 2013, 617
Disclaimer
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