All Substitutes
Loading...
Disclaimer
Did you find this information helpful?
  Â
Neotagmin Injection
Prescription Required
Salt Composition : Neostigmine Methyl Sulphate
Manufacturer : THEMIS MEDICARE
Origin of Medicine : India
1 Ampoule(s) Of 5ml
Introduction to Neotagmin Injection
Neotagmin injection contains an active component such as Neostigmine methyl sulphate. It is a medication primarily used to treat myasthenia gravis, a neuromuscular disorder that leads to muscle weakness and fatigue. It can be used to treat postoperative paralytic ileus, a condition where the normal contractions of the intestines are reduced or absent after surgery. It helps enhance gastrointestinal motility. This medication can reverse the effects of certain muscle relaxants used during surgical procedures. In some cases, it may be used to manage orthostatic hypotension, a condition where blood pressure drops significantly upon standing up. It might be used to manage certain types of dysautonomia and autonomic nervous system disorders that can lead to various symptoms, including dizziness, heart rate irregularities, and difficulty regulating body temperature.
You should not use it if you have a known allergy or hypersensitivity to Neotagmin injection or any ingredients in the medication. It can affect heart rate and cardiac conduction, so it should be avoided for individuals with bradycardia (slow heart rate) or heart block. It may worsen symptoms in individuals with uncontrolled hyperthyroidism. It should not be used as a treatment for hyperthyroidism. It can exacerbate respiratory symptoms and is not used to treat acute asthma attacks. It can be used in children with myasthenia gravis or other neuromuscular conditions, but the dosage and administration might differ from adults. Neotagmin injection can be used in the elderly, but dosage adjustments might be necessary due to potential age-related changes in metabolism and other health considerations.
Uses of Neotagmin Injection
Neotagmin injection is used in the following:
- Myasthenia gravis management
- Reversal of neuromuscular blockade
- Postoperative paralytic ileus treatment
- Orthostatic hypotension management
- Dysautonomia symptom relief
- Reversal of neuromuscular effects
Therapeutic Effects of Neotagmin Injection
Neotagmin injection works by inhibiting the action of acetylcholinesterase, an enzyme that breaks down the neurotransmitter acetylcholine. By inhibiting this enzyme, Neotagmin injection increases the levels of acetylcholine in the neuromuscular junction, which improves muscle function.
Interaction of Neotagmin Injection with other drugs
Inform the doctor about your medicines, including prescription, over-the-counter, nutritional or vitamin supplements, and herbal products. Certain medications may interact with Neotagmin injection, reducing effectiveness by causing undesirable side effects.Â
More Information about Neotagmin Injection
- Store at room temperature, between up to 20°C to 25°C
- Keep away from moisture, heat, and light.
- It should not be frozen.
- Keep away from children and pets.
How to consume Neotagmin Injection
A healthcare provider can administer Neotagmin injection as an intravenous injection. The healthcare provider determines the exact dose, duration, and frequency.
Safety Advices for Neotagmin Injection
 Â
Pregnancy
 Â
The safety of Neotagmin injection during pregnancy should be discussed with your healthcare provider. They will consider the potential risks and benefits before making a recommendation.
 Â
Breast Feeding
 ÂNeotagmin injection might pass into breast milk, potentially affecting the nursing infant. Consult your healthcare provider before starting this medication.
 Â
Lungs
  Neotagmin injection can worsen respiratory symptoms, so individuals with lung conditions like asthma should consult a healthcare provider before using this medication.
 Â
Liver
  Neotagmin injection might not be suitable for individuals with certain types of liver disease. It's important to discuss your specific liver condition with your healthcare provider before using it.
 Â
Alcohol
 Â
It is not safe to use alcohol while taking Neotagmin injection , as alcohol might enhance certain side effects and interactions.
 Â
Driving
  Neotagmin injection can cause side effects like dizziness or blurred vision, which could impair your ability to drive safely. Consult your healthcare provider for guidance.
Side Effects of Neotagmin Injection
Neotagmin injection can cause some side effects like all medications, although not everyone will experience them.Â
Serious
- Severe allergic reactions (rash, itching, swelling, severe dizziness, difficulty breathing)
- Slow heart rate (bradycardia)
- Heart rhythm abnormalities
- Muscle weakness or twitching (beyond normal myasthenic symptoms)
- Difficulty breathing or swallowing
- Increased or uncontrolled muscle movements
- Signs of cholinergic crisis (overdose)
Common
- Nausea
- Vomiting
- Diarrhea
- Abdominal cramps
- Increased salivation
- Sweating
- Muscle twitching or cramps
- Blurred vision
- Increased urination
- Difficulty focusing
Word of Advice
Inform your healthcare provider about allergies, medical history (including heart, lung, gastrointestinal, and neurological conditions), and any medications you're taking before using Neotagmin injection. Dosage adjustments might be needed for liver or kidney impairments. Regular monitoring for side effects, signs of overdose (cholinergic crisis), and response to treatment is crucial. If you have respiratory conditions, cardiovascular issues, or neurological disorders, discuss their impact on its use. Avoid abrupt discontinuation, self-administration of injections, and sudden changes to treatment. Store this medication properly, and consult your healthcare provider for any concerns or adjustments to your treatment plan.
FAQs
Q 1. Is using Neotagmin injection safe for a long period?
Long-term use of Neotagmin injection is common for conditions like myasthenia gravis. Your healthcare provider will monitor you for any adverse effects of prolonged usage.
Q 2. How long does it take for Neotagmin injection to start working?
The onset of action can vary, but some individuals might experience improvements within a few hours to days after starting Neotagmin injection.
Q 3. Can I stop taking Neotagmin injection abruptly?
Abruptly stopping Neotagmin injection can lead to a worsening of symptoms. Consult your healthcare provider before making any changes to your treatment plan.
Q 4. Can Neotagmin injection affect my exercise or physical activity ability?
Depending on your response to Neotagmin injection, it might impact your physical abilities. Discuss any changes or concerns with your healthcare provider.
Q 5. Are there specific dietary restrictions while taking Neotagmin injection?
There are generally no specific dietary restrictions, but if you have concerns about certain foods affecting your condition or medication, discuss them with your healthcare provider.
Q 6. Are the side effects of Neotagmin injection temporary?
Some side effects, like nausea or vomiting, might temporarily improve over time as your body adjusts to the medication.
Fact Box of Neotagmin Injection
Molecule name: Â Neostigmine methyl sulphate | Therapeutic class: Anticholinesterases |
Pharmacological class:Â Cholinesterase Inhibitor | Indications:Â 1. Myasthenia gravis management 2. Reversal of neuromuscular blockade 3. Postoperative paralytic ileus treatment 4. Orthostatic hypotension management 5. Dysautonomia symptom relief 6. Reversal of neuromuscular effects |
References
- Goodman & Gilman’s, The Pharmacological Basis of Therapeutics, Anticholinesterase agents, 12th edition, 2011, 250.
- KD Tripathi, Essentials of Medical Pharmacology, Cholinergic system and drugs, 7th edition, 2013, 105-111.
- Hameln Pharma Ltd, Electronic medicines compendium (EMC), [Revised on Dec 2020] [ Accessed on 30th August 2023], https://www.medicines.org.uk/emc/files/pil.6268.pdf
- Fresenius kabi USA LLC, US Food and Drug Administration, [Revised on Jan 2015] [ Accessed on 30th August 2023], https://www.accessdata.fda.gov/drugsatfda_docs/label/2015/203629s000lbl.pd
Disclaimer
MrMed’s primary intention is to ensure that its consumers get information that is reviewed by experts, accurate and trustworthy. The information and contents of this website are for informational purposes only. They are not intended to be a substitute for professional medical advice, diagnosis, or treatment. Please seek the advice of your doctor and discuss all your queries related to any disease or medicine. Do not disregard professional medical advice or delay in seeking it because of something you have read on MrMed. Our mission is to support, not replace, the doctor-patient relationship.
