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Neptaz 100mg Tablet
Prescription Required
Salt Composition : Sacubitril,valsartan
Manufacturer : MANKIND PHARMACEUTICALS LIMITED
Origin of Medicine : India
28 Tablet(s) In A Strip
Introduction to Neptaz 100mg Tablet
Neptaz 100mg Tablet contains two active substances, Sacubitril and Valsartan. It is a cardiovascular agent that belongs to angiotensin receptor-neprilysin inhibitors (ARNi). It is used to treat a type of long-term heart failure in adults. This combination is used with other medications to lower the risk of death and hospitalisation in adults with certain types of heart failure.
Do not take Neptaz 100mg Tablet if you are allergic to Sacubitril, valsartan, or any of the other ingredients of this medicine. Do not take this medicine if you are having or ever had a reaction called angioedema (swelling of the face, lips, tongue, and throat, and difficulties in breathing). Do not take this medicine if you have diabetes or impaired kidney function and if you are being treated with a blood pressure-lowering medicine containing Aliskiren. Do not consume this tablet if you have severe liver disease or are pregnant and breastfeeding.  Â
Inform your doctor if you are taking any other heart medicines before starting this medicine. Tell your doctor if you have low blood pressure, severe kidney disease, dehydration, liver disease, hallucinations, or changes in your sleeping pattern. The most common side effects of Neptaz 100mg Tablet are hypotension, increased potassium levels, cough, dizziness, and renal failure.Â
Uses of Neptaz 100mg Tablet
- To reduce the risk of cardiovascular death and hospitalization in adults with heart failure.
Therapeutic Effects of Neptaz 100mg Tablet
Sacubitril is a prodrug metabolized to the active metabolite, which inhibits neprilysin, thereby increasing levels of peptides (such as natriuretic peptides). It works to help control blood volume. Valsartan is an angiotensin receptor blocker that selectively blocks the AT1 receptor and inhibits angiotensin-II-dependent aldosterone release. It works by blocking the action of certain natural substances that tighten the blood vessels, allowing the blood to flow more smoothly and the heart to pump more efficiently.
Interaction of Neptaz 100mg Tablet with other drugs
Inform your healthcare provider about all the medicines you take, including prescription medications, over-the-counter medications, nutritional and vitamin supplements, and herbal products. Certain medications may interact with Neptaz 100mg Tablet and reduce its effectiveness by causing undesirable side effects. Inform your physician if you are taking medicines that contain aliskiren.Â
More Information about Neptaz 100mg Tablet
- Do not store above 25°C).
- Store in the original package to protect from light.
- keep the injection away from the reach of children and pets.
How to consume Neptaz 100mg Tablet
Always take this medicine exactly as your doctor or pharmacist has told you. Your physician will decide the dose and duration of the treatment based on your disease severity and other factors. Swallow the tablets with a glass of water. You can take Neptaz 100mg Tablet with or without food. Do not crush, chew, or split the tablets.Â
Safety Advices for Neptaz 100mg Tablet
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Pregnancy
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Do not take Neptaz 100mg Tablet if you are pregnant because it may cause harm to the unborn baby. Inform your physician if you are pregnant, suspect pregnancy, or planning to become pregnant.
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Breast Feeding
 ÂBreastfeeding is not recommended in patients taking Neptaz 100mg Tablet because the medicine passes into the breast milk in small amounts and may harm your baby.Â
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Lungs
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It is unknown whether Neptaz 100mg Tablet can be used in patients with lung disorders. Consult your doctor if you have any lung diseases before starting the treatment
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Liver
  Neptaz 100mg Tablet should be cautiously given in patients with liver problems. Dose adjustments are necessary. Inform your physician if you have any liver diseases or problems before initiating the therapy.Â
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Alcohol
 ÂIt is unknown whether consuming alcohol is safe during the treatment with Neptaz 100mg Tablet. Inform your doctor if you are a chronic drinker.Â
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Driving
  Neptaz 100mg Tablet can make you feel tired, dizzy, or sleepy. Do not drive or operate heavy machinery if this medicine affects you.Â
Side Effects of Neptaz 100mg Tablet
Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them.
Common
- Low blood pressure
- Increased potassium levels
- Dizziness
Serious
- Kidney damage
- Angioedema (swelling of the face, lips, tongue and throat, and difficulties in breathing)
Word of Advice
It is advisable to take your medicine at the same time each day. However, if you forget to take a dose, you should take the next one at the scheduled time. Do not take a double dose to make up for a forgotten tablet. Inform your physician if you have kidney problems before initiating the therapy. This medicine could lower your blood pressure too much, especially when you first use it or if you are dehydrated. Stand or sit up slowly if you feel dizzy or lightheaded. Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
FAQs
Q 1. What is Neptaz 100mg Tablet?
Neptaz 100mg Tablet is a combination medication for treating heart failure in adult patients. It contains two active ingredients, sacubitril, and valsartan, which work together to improve heart function and reduce the risk of hospitalization and cardiovascular deaths.
Q 2. What are the common side effects of Neptaz 100mg Tablet?
Common side effects of Neptaz 100mg Tablet may include low blood pressure, dizziness, increased heart rate, cough, and elevated potassium levels in the blood. It is important to report any unusual or severe side effects to your healthcare provider
Q 3. Is regular monitoring required during Neptaz 100mg Tablet treatment?
Regular monitoring of blood pressure, kidney function, and potassium levels may be required during Neptaz 100mg Tablet treatment. Your healthcare provider will determine the appropriate monitoring schedule based on your needs.
Q 4. Can I take Neptaz 100mg Tablet with or without food?
The combination of valsartan and sacubitril is a tablet to take by mouth. Take the tablet as prescribed by your doctor. It is usually taken with or without food. To help you remember to take the combination of valsartan and sacubitril, take it at around the same times every day.
Q 5. Can Neptaz 100mg Tablet interact with other medications?
Neptaz 100mg Tablet may interact with certain medications and cause undesirable side effects. It is important to inform your healthcare provider about all your medications to avoid potential drug interactions. Inform your physician if you are taking medications containing Aliskiren.
Fact Box of Neptaz 100mg Tablet
| Molecule name: Sacubitril + Valsartan | Therapeutic class: Cardiovascular agents |
Pharmacological class:Â 1. Sacubitril - Neprilysin Inhibitors 2. Valsartan - Angiotensin II receptor antagonist | Indications: To reduce the risk of cardiovascular events due to heart failure |
References
- Novartis Pharmaceuticals UK Ltd, Electronic Medicines Compendium(EMC), [Revised on June 2023 [Accessed on 14th June 2023], https://www.medicines.org.uk/emc/files/pil.5074.pdf
- Novartis, US Food and Drug Administration, [Revised on February 2021] [Accessed on 14th June 2023], https://www.accessdata.fda.gov/drugsatfda_docs/label/2021/207620s018lbl.pdf
- KD Tripathi, Cardiac Glycosides and Drugs for Heart Failure, Essentials of Medical Pharmacology, 8th Edition, 2019, 556-569.
- Ian A. Reid, Vasoactive Peptides, Lange’s Basic & Clinical Pharmacology, 14th Edition, 2018, 300-320.
Disclaimer
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