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Parbraze 150mg Tablet
Prescription Required
Salt Composition : Olaparib
Manufacturer : ABBOTT
Origin of Medicine : India
60 Tablet(s) In A Bottle
Introduction to Parbraze 150mg Tablet
Parbraze 150mg Tablet belongs to the class of cancer medications known as PARP (poly [adenosine diphosphate-ribose] polymerase inhibitor) inhibitors. It contains the active ingredient Olaparib. It is used to treat ovarian, breast, pancreatic, and prostate cancer. This medication can be given alone or in combination with other anticancer medications.
It is not recommended to take olaparib if you are allergic to the active compound and other ingredients of the medicine. Speak with your doctor immediately if you experience breathlessness, chest pain, rapid heart rate, fever, cough, or wheezing. Your healthcare provider will conduct blood tests before and every month during the treatment, as this medicine could reduce the counts of RBC, WBC, and platelets. Tell your healthcare provider before starting treatment if you have been diagnosed with problems in your lungs, liver, heart, or kidneys.
It is not advised to use this medication while pregnant since it may harm the fetus and cause miscarriage. Therefore, for women of reproductive age, it is recommended to get a pregnancy test before beginning this medication. It is preferable to keep using birth control for at least six months after treatment is finished. While receiving treatment, it is not advised to breastfeed your child because it is unknown if the Parbraze 150mg Tablet will find its way into the breast milk. Men are not advised to donate sperm for at least 3 months after the treatment is finished. It is necessary to inform your doctor about all the medicines you are taking, including prescription, over-the-counter drugs, vitamins and supplements.
Uses of Parbraze 150mg Tablet
Parbraze 150mg Tablet is used to treat,
- Maintenance therapy for various types of Advanced ovarian cancer
- Treatment of early and metastatic Breast cancer
- Treatment of Prostate cancer
- Metastatic Pancreatic cancer
Therapeutic Effects of Parbraze 150mg Tablet
Parbraze 150mg Tablet works by inhibiting the enzyme poly (ADP-ribose) polymerase (PARP), which plays a role in repairing damaged DNA in cells. By inhibiting PARP, Parbraze 150mg Tablet prevents cancer cells from repairing their DNA, leading to cell death. This targeted approach is especially effective in cancers with defective DNA repair mechanisms.
Interaction of Parbraze 150mg Tablet with other drugs
Inform your healthcare provider about all the medicines you take, including prescription, over-the-counter, nutritional or vitamin supplements, and herbal products. Certain medications may interact with Parbraze 150mg Tablet and reduce effectiveness by causing undesirable side effects.
More Information about Parbraze 150mg Tablet
- Store Parbraze 150mg Tablet Tablet in the original package at room temperature (20°C to 25°C).
- Keep it out of reach of children.
How to consume Parbraze 150mg Tablet
The medicine will be prescribed to you by a healthcare professional in a hospital setting. Parbraze 150mg Tablet is to be taken with or without food, as directed by your healthcare provider. The dose will be decided by your healthcare professional based on your conditions. Avoid crushing, opening, or dissolving the tablet and swallow it whole with a glass of water. Take the Parbraze 150mg Tablet at the same time every day.
Safety Advices for Parbraze 150mg Tablet
Pregnancy
It is not recommended to take Parbraze 150mg Tablet during pregnancy as it may harm your unborn baby. It is necessary to inform your doctor if you are pregnant or planning to become pregnant.
Breast Feeding
It is unknown whether Parbraze 150mg Tablet passes into the breast milk. It is not recommended to nurse a child during and after 1 month of completion of therapy. Please consult your doctor before breastfeeding.
Lungs
Consult your doctor if you have any lung diseases before starting the treatment with Parbraze 150mg Tablet.
Liver
It is unknown whether Parbraze 150mg Tablet is safe in individuals with liver disorders. Inform your physician if you have any liver problems before starting the treatment.
Alcohol
It is unknown whether consuming alcohol interacts with the Parbraze 150mg Tablet. Please consult your doctor for more advice.
Driving
Parbraze 150mg Tablet may have an impact on your ability to operate machinery and drive. It is not recommended to operate machinery or drive vehicles if you experience lightheadedness, weakness, or exhaustion.
Side Effects of Parbraze 150mg Tablet
Side effects are unwanted symptoms caused by medicines. Although all drugs cause side effects, not everyone experiences them.
Common:
- Shortness of breath
- Nausea
- Vomiting
- Fatigue
- Dyspepsia
- Loss of appetite
- Dizziness
- Diarrhoea
- Headache
Serious:
- Neutropenia
- Acute myeloid leukemia
- Leukopenia
- Thrombocytopenia
- Lung problems
Word of Advice
Parbraze 150mg Tablet can lower blood cell counts. Thus, it's best to get blood tests done at regular intervals. When undergoing this therapy, stay out of direct sunlight and wear sunscreen with an SPF of at least 50 before going outside. Parbraze 150mg Tablet should not be stopped without first talking to your doctor.
When using this medication, stay away from grapefruit juice as it may raise your blood levels of the drug. It is recommended to inform your doctor about other anticancer drugs you have been taking. It's critical to maintain a sufficient fluid intake because dehydration can exacerbate symptoms such as diarrhoea and other gastrointestinal disorders. Even if you feel better or see a change in your symptoms, you should still talk to your doctor before stopping Parbraze 150mg Tablet.
Remember to attend all scheduled appointments and follow-up visits with your healthcare provider to ensure your treatment is effective and any side effects are managed appropriately. With proper monitoring and management, Parbraze 150mg Tablet can be an effective treatment option for certain types of cancer.
FAQs
Q 1. Can Parbraze 150mg Tablet be taken during pregnancy or breastfeeding?
Parbraze 150mg Tablet may harm an unborn baby and should not be used during pregnancy. It is also not recommended while breastfeeding, as it may pass into breast milk and harm the nursing infant.
Q 2. What are Parbraze 150mg Tablet's typical side effects?
Adverse effects include nausea, vomiting, lethargy, diarrhoea, appetite loss, and blood cell count abnormalities.
Q 3. Are there any dietary restrictions I need to follow while on Parbraze 150mg Tablet?
There are no specific dietary restrictions associated with Parbraze 150mg Tablet. However, it's essential to maintain a healthy and balanced diet to support overall well-being during treatment. Grape juice should be avoided, as it increases the blood drug concentration.
Q 4. Is Parbraze 150mg Tablet used as a standalone treatment in cancers?
Parbraze 150mg Tablet is usually indicated as maintenance therapy after a person completes a platinum-based chemotherapy regimen for ovarian cancer. However, newer studies are evaluating its solitary efficacy in treating different types of cancers.
Q 5. Can I drive or operate machinery while taking Parbraze 150mg Tablet?
Parbraze 150mg Tablet may cause side effects such as dizziness or fatigue, which could impair your ability to drive or operate machinery safely. If you're unsure, it's best to consult with your healthcare provider for personalized advice based on your specific situation.
Fact Box of Parbraze 150mg Tablet
Molecule Name: Olaparib | Therapeutic class: Antineoplastic agents |
| Pharmacological class: Poly Adenosine Diphosphate-Ribose Polymerase (PARP) inhibitor | Indications: 1. Maintenance therapy for various types of Advanced ovarian cancer 2. Treatment of early and metastatic Breast cancer 3. Treatment of Prostate cancer 4. Metastatic Pancreatic cancer |
Dosage form: Tablets | Habit forming: No |
References
- Lynparza, United States Food and Drug Administration (USFDA), [Revised on May 2020], [Accessed on March 2024], https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/208558s014lbl.pdf
- AstraZeneca UK Limited, European Medicines Compendium (emc), [Revised on August 2023], [Accessed on March 2024], https://www.medicines.org.uk/emc/files/pil.9204.pdf
- AstraZeneca Pharmaceuticals LP, [Revised on November 2023], [Accessed on March 2024], https://den8dhaj6zs0e.cloudfront.net/50fd68b9-106b-4550-b5d0-12b045f8b184/00997c3f-5912-486f-a7db-930b4639cd51/00997c3f-5912-486f-a7db-930b4639cd51_viewable_rendition__v.pdf
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