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Regdual 40mg Tablet
Prescription Required
Salt Composition : Regorafenib
Manufacturer : INTAS PHARMACEUTICALS LTD
Origin of Medicine : India
28 Tablet(s) In A Bottle
Introduction to Regdual 40mg Tablet
Regdual 40mg Tablet is a targeted therapy containing the active constituent regorafenib. It is used to treat colon cancer, rectal cancer, liver cancer, and gastrointestinal stromal tumors (GIST) (a type of cancer of the stomach and bowel). Cancer is a disorder in which cells multiply in an uncontrolled and abnormal manner.
Talk to your doctor if you have any liver disorders, infection, bleeding problems, stomach and bowel problems, chest pain, heart diseases, high blood pressure, persistent headache, seizures, or if you recently had or going to have a surgical procedure before taking this medicine. Regdual 40mg Tablet is not recommended for adolescents and children.
Avoid drinking grapefruit juice while taking this medicine, as it can affect the way this medicine works. Use effective birth control during the treatment and for at least eight weeks after the last dose. Talk to your doctor if you are on a salt-controlled diet as Regdual 40mg Tablet contains sodium.
Uses of Regdual 40mg Tablet
- Colorectal cancer has started to spread to other parts of the body
- Gastrointestinal stromal tumors (GIST) (a type of stomach and bowel cancer)
- Liver cancer in adult patients who have already undergone treatment with Sorafenib (anticancer medicine)
Therapeutic Effects of Regdual 40mg Tablet
Regdual 40mg Tablet binds to tyrosine kinase receptors and inhibits the VEGF (vascular endothelial growth factor) and EGFR (epidermal growth factor receptor) receptors on the cell surface. By binding to these receptors, this medication blocks an important pathway that promotes cell division. This helps to prevent the growth and multiplication of cancer cells.
Interaction of Regdual 40mg Tablet with other drugs
Inform your doctor about all the prescription medications, over-the-counter drugs, vitamins, and herbal supplements you are taking or have taken before starting treatment with Regdual 40mg Tablet. Certain medications may interact with Regdual 40mg, potentially causing adverse effects. For example, the concurrent use of CYP3A4 inhibitors such as ketoconazole and certain antibiotics may alter the effectiveness of Regdual or increase the risk of side effects. Always consult your healthcare provider before combining therapies.
More Information about Regdual 40mg Tablet
- Keep this medicine out of sight and reach of children.
- Store at room temperature between 20°C to 25°C.
How to consume Regdual 40mg Tablet
Always take this medicine exactly as your doctor has told you. Swallow the tablets whole with water. Do not crush or chew the tablets. Avoid drinking grapefruit juice while taking this medicine.
Safety Advices for Regdual 40mg Tablet
Pregnancy
This medicine is not safe to be used in pregnancy. Consult with your doctor for advice.
Breast Feeding
It is not recommended to breastfeed while taking Regdual 40mg Tablets. Consult with your doctor for advice
Lungs
Regdual 40mg Tablet may cause lung-related side effects, such as interstitial lung disease. It should be used with caution in patients with pre-existing lung conditions. Consult with your doctor for advice.
Liver
Regdual 40mg Tablets should be used with caution in patients suffering from liver diseases. Consult with your doctor for advice.
Alcohol
It is not recommended to consume alcohol while taking Regdual 40mg Tablets, as it may increase the risk of liver damage and other side effects. Consult with your doctor for advice.
Driving
Regdual 40mg Tablet may cause dizziness, fatigue, or visual disturbances, which could impair your ability to drive. Avoid driving or operating heavy machinery if you experience these symptoms. Consult with your doctor for advice.
Side Effects of Regdual 40mg Tablet
Side Effects are unwanted symptoms caused by medicines. Although all medicines cause side effects, not everyone gets them.
Severe:
- Liver problems (yellowish discoloration of skin and whites of the eyes, dark urine, confusion)
- Bleeding
- Infection (high fever, cough with or without sputum, pain when urinating, unusual vaginal discharge, shortness of breath)
- Stomach and bowel problems (severe stomach pain, blood in vomit, red or black stools)
Common:
- Low blood cell count
- Decreased appetite, weight loss
- Nausea, vomiting
- High blood pressure
- Voice changes
- Diarrhea
- Dry mouth, painful tongue, mouth sores
- Changes in liver function
- Weakness, lack of energy
- Pain, redness, blisters and swelling of palms of the hands or soles of the feet
- Dehydration
- Hair loss, dry skin
- Headache
- Heartburn
- Low levels of potassium, phosphate, calcium, sodium or magnesium in blood
- Shaking
- Numbness, tingling
- Taste disorders
- Muscle spasms
- Abnormal clotting condition
- Protein in the urine
Word of Advice
Before starting Regdual 40mg Tablet, inform your doctor if you have any liver conditions, infections, bleeding problems, heart diseases, high blood pressure, stomach or bowel issues, or are undergoing surgery. This medication is not recommended for children and adolescents. Avoid consuming grapefruit juice while on Regdual, as it may reduce the drug's effectiveness. Women who are pregnant, planning pregnancy, or breastfeeding should avoid using this medicine due to the potential harm to the developing baby. Always consult your doctor for guidance.
FAQs
Q 1. Can I take Regdual 40mg with food?
Yes, it should be taken with a low-fat meal to improve absorption.
Q 2. What should I do if I miss a dose?
If you miss a dose, take it as soon as you remember. If it's close to your next dose, skip the missed one. Never double up doses to make up for a missed dose.
Fact Box of Regdual 40mg Tablet
Molecule name: Regorafenib
| Therapeutic Class: Antineoplastic Agent |
Pharmacological Class: Multikinase Inhibitor | Indications: 1. Colorectal cancer (metastatic) 2. Gastrointestinal stromal tumors (GIST) that are unresectable or have metastasized 3. Hepatocellular carcinoma (HCC) in patients who have been previously treated with sorafenib |
References
- Bayer AG; Electronic Medicines Compendium; [Revised:2019] [Accessed:29/Apr:2021] https://www.medicines.org.uk/emc/files/pil.1263.pdf
- TJ Ettrich et al; Regorafenib; [Revised:2014] [Accessed:29/Apr/2021] https://pubmed.ncbi.nlm.nih.gov/24756792/
- Dirk Strumberg; Regorafenib for cancer; [Revised:2012] [Accessed:29/Apr/2021] https://pubmed.ncbi.nlm.nih.gov/22577890/
- Bayer HealthCare Pharmaceuticals Inc; US Food And Drug Administration; [Revised:2012] [Accessed:29/Apr/2021] https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/203085lbl.pdf
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