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Rivofonet Tablet
Prescription Required
Salt Composition : Tenofovir Disoproxil Fumarate
Manufacturer : EMCURE PHARMACEUTICALS LTD
Origin of Medicine : India
30 Tablet(s) In A Bottle
Introduction to Rivofonet Tablet
Rivofonet tablet consists of an active substance called Tenofovir Disoproxil Fumarate, which belongs to the class of antiretroviral or antiviral medicine. This medicine treats HIV (human immunodeficiency virus) and HBV (hepatitis B virus) infections. It is a nucleotide reverse transcriptase inhibitor (NRTI) and works by inhibiting the enzymes (HIV reverse transcriptase; hepatitis B DNA polymerase) that are important for virus replication. It should always take in combination with other medicines to treat HIV infection. This tablet is suitable for the adult and adolescents aged from 12 to 18 years. For HIV, this medicine is given to adolescents who have already been medicated with other HIV medicines which are no longer fully effective due to resistance or have caused side effects. This tablet is not studied in patients over 65 years of age.
Do not consume this drug if you have experienced hypersensitivity reactions to Tenofovir disoproxil fumarate or any of its ingredients. During the Rivofonet tablet treatment, your doctor may periodically monitor your blood counts, bone mineral density, liver and kidney parameters to prevent serious complications. Report to your doctor if you have had a history of heart failure, pancreatitis, bone disease (osteonecrosis - the death of bone tissue), fractures, liver (chronic hepatitis B or C), or kidney problems.Â
Rivofonet tablet should not be given to adolescents with existing kidney problems. If you have lactose intolerance, notify your doctor before starting the treatment. Inform your doctor if you planning to get pregnant, or pregnant, or think you may be pregnant. Breastfeeding is not recommended due to the potential transmission of HIV. Use effective contraception to avoid transmission of HIV infection from patients.
Uses of Rivofonet Tablet
- Treatment of HIV and HBV infections
Therapeutic Effects of Rivofonet Tablet
The reverse transcriptase enzyme produces copies of DNA from the HIV’s RNA. Rivofonet tablet is a nucleotide analog that inhibits the reverse transcriptase enzyme and blocks DNA synthesis. It decreases the viral load of HIV in the blood and increases the number of CD4 (T) cells, enabling the immune system to fight other infections. This reduces the risk of severity and death associated with a weak immune system.
Interaction of Rivofonet Tablet with other drugs
Inform your doctor about any prescribed medications, over-the-counter medicines, nutritional or vitamin supplements, and herbal products you take or have taken before the treatment. Certain medications may interact with the Rivofonet tablet and can cause undesirable side effects.
More Information about Rivofonet Tablet
- Store at a temperature not exceeding 30°C.
- Keep away from moisture, heat, and light.
- Do not freeze the medicine.
- Keep out of the reach of children and pets.
How to consume Rivofonet Tablet
Rivofonet tablet is available as film-coated tablets in a dose of 300mg. The usual recommended dosage of this medication is one tablet every day, with or without food. For adults and children with body weight over 3.5kg, the usual recommended dose is 300mg per day. Your physician will choose the dosage and administration frequency based on the medical condition because it differs for each person.
Safety Advices for Rivofonet Tablet
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Pregnancy
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Notify your healthcare professional if you are pregnant or planning to have a baby think you may be pregnant. Your physician will conduct regular tests to monitor the development of your child. Ask for suggestions before taking the Rivofonet tablet.
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Breast Feeding
 ÂIt is unsafe to breastfeed if you are with HIV infection. HBV patients may be able to breastfeed their newborn, but first, talk to their doctor for more information. Consult your doctor for more information about Rivofonet tablet.Â
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Lungs
  It is unknown whether the Rivofonet tablet is safe for patients with lung problems. Inform your physician if you have any lung disease before starting the treatment. Contact your doctor if you experience any lung-related symptoms.
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Liver
  Inform your physician about any underlying liver disorders before taking Rivofonet tablet, as this medication should be used with caution in liver disease patients. Consult your physician before taking this medicine.
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Alcohol
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Do not consume alcohol while taking the Rivofonet tablet, as this injection may cause drowsiness with alcohol.
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Driving
  It is unsafe to drive while taking Rivofonet tablet because this medicine might cause vision problems and tiredness, so avoid driving and operating machinery during this treatment.
Side Effects of Rivofonet Tablet
Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them.
Serious
- Pancreas problems
- Kidney damage
- Deep, rapid breathing
- Drowsiness
- Nausea, vomiting
- Infection
- Lactic acidosis
Common
- Headache
- Stomach pain
- Tiredness
- Bloating, flatulence
- Low phosphate levels in the blood
- Diarrhea
- Dizziness
- Rash
- Weakness
Word of Advice
Inform your doctor about your underlying infections. If you have advanced HIV (AIDS), you may develop signs of infection and inflammation or worsening the signs of an existing infection once treatment is started. Report your doctor for side effects. It is very mandatory to tell your medical professional if you are consuming other medicines that may damage your kidneys. Always consume the dose recommended by your doctor. Rivofonet tablet does not reduce the risk of passing on HBV to others through sexual contact or blood contamination. You must continue the medication to avoid this complication. Â
FAQs
Q 1. Can you consume alcohol while on treatment with Rivofonet tablet?
Rivofonet tablet is associated with a higher risk of liver damage and impairment. Consuming alcohol while on this treatment adds to the risk of liver injury.
Q 2. What are the required laboratory parameters before starting Rivofonet tablet?
If you are an adolescent or adult of childbearing potential, your healthcare provider will perform a pregnancy test before prescribing this treatment. Other prominent tests include HBV infection, estimated creatinine clearance, serum creatinine, urine glucose, and urine protein.
Q 3. How do you know if you are hypersensitive to Rivofonet tablet?
Watch out for symptoms like severe rash, rash accompanied by fever, muscle pain, extreme tiredness, facial edema, breathing difficulty, blisters, and peeling of the skin, and reach out to your healthcare provider immediately if you notice any of these symptoms.
Q 4. What are the symptoms of lactic acidosis?
Unusual weakness, tiredness, muscle pain, trouble breathing, stomach pain, nausea, vomiting, dizziness, lightheadedness, irregular heartbeat, and feeling cold in your arms and legs, are the most prominent symptoms of lactic acidosis.
Q 5. Can I dissolve the Rivofonet tablet and drink it instead of swallowing it?
No, you should not dissolve the Rivofonet tablet and drink the solution. This medicine was designed to be swallowed whole with water. It's mandatory to follow the instructions provided by your healthcare provider to avoid the side effects of the medicine.
Fact Box of Rivofonet Tablet
Molecule name: Tenofovir Disoproxil Fumarate | Therapeutic class: Antiretrovirals |
Pharmacological class:Â Nucleoside reverse transcriptase inhibitors (NRTIs) | Indications:Â 1. HIV Infection 2. Hepatitis B Infection |
References
- KD Tripathi, Antiviral Drugs (Anti-retrovirus), Essentials of Medical Pharmacology, 8th Edition, 2019, 860-872.
- Gilead Sciences, Inc., U.S. Food and Drug Administration, [Revised on Apr 2019] [Accessed on 19th May 2022], https://www.accessdata.fda.gov/drugsatfda_docs/pepfar/210787PI.pdf
- Cipla (EU) Limited, Electronic medicines compendium (emc), [Revised on Nov 2021], [ Accessed on 19th May 2023], https://www.medicines.org.uk/emc/files/pil.9932.pdf
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